ABSTRACT
This work is a result of authors' reflection on the necessity of conceptual changes in the area of mental health. The authors aimed at understanding the essential aspects involving the theme according to the conception of paradigm, as well as the process in which the crisis appears emerging anomalies and pointing out the inefficiency of the present paradigm. Thus, they suggested a change from the actual model to another one based on a perspective that emphasizes patient's freedom and the relational character of human expressiveness.
Subject(s)
Mental Health , Humans , PsychiatryABSTRACT
The dye-sensitized photooxygenation of DL-tryptophan in aqueous solution leads to the tricyclic compound 2-carboxy-3a-hydroperoxy-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indole which, on reduction with dimethyl sulfide, furnishes two diastereoisomeric alcohols separable by fractional crystallization into a higher melting (mp 254 degrees -256 degrees ) and a lower melting (mp 228 degrees ) diastereoisomer. Each of these alcohols was correlated with one of the analogous pair of isomeric 1,2-dicarbomethoxy analogs by alkaline hydrolysis and by x-ray analysis. In this way, the 3a-hydroxy-1,2-dimethoxycarbonyl- 1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indole, mp 163 degrees -164 degrees , was shown to have the trans configuration with regard to the relative positions of the hydroxyl and carbomethoxy groups and that, on alkaline hydrolysis, it produced the isomer with mp 228 degrees , which therefore also has the trans configuration. The mechanism of the smooth thermal rearrangement of the (presumably ring-chain tautomeric) tryptophan hydroperoxy intermediates to formylkynurenine is discussed with its implications for the biological oxidation by tryptophan 2,3-dioxygenase.
