ABSTRACT
We describe 2 patients with clinical syndromes suggestive of Wegener's granulomatosis: elevated titers of cytoplasmic antineutrophil cytoplasmic antibodies (cANCA), bronchocentric granulomatosis, and acute renal failure. A renal biopsy in one case showed crescentic glomerulonephritis and in the other case showed interstitial nephritis. These cases may reflect bronchocentric granulomatosis among a spectrum of diseases associated with cANCA. Use of cANCA may identify those patients with bronchocentric granulomatosis who require immunosuppressive therapy.
Subject(s)
Acute Kidney Injury/immunology , Autoantibodies/analysis , Bronchial Diseases/immunology , Granuloma/immunology , Granulomatosis with Polyangiitis/immunology , Acute Kidney Injury/diagnosis , Acute Kidney Injury/pathology , Aged , Aged, 80 and over , Antibodies, Antineutrophil Cytoplasmic , Biomarkers , Biopsy , Bronchial Diseases/diagnosis , Female , Glomerulonephritis/diagnosis , Glomerulonephritis/pathology , Granuloma/diagnosis , Granulomatosis with Polyangiitis/diagnosis , Humans , Kidney/pathology , Male , Nephritis, Interstitial/diagnosis , Nephritis, Interstitial/pathologyABSTRACT
Corynebacterium group D2 is a gram-positive bacillus easily identified in clinical microbiology laboratories. However, this organism is often disregarded as a skin and mucous contaminant. The Spanish literature has recently described Corynebacterium group D2 as a urinary pathogen in a specific patient population. We report a case of Corynebacterium group D2 infection to illustrate the potential pathogenicity and clinical presentation of infection due to this organism in the United States.
