ABSTRACT
Intestinal dysbiosis has been associated with acute gastrointestinal GvHD and poor outcome following allogeneic stem cell transplantation (ASCT). To assess the effect of a switch in 2012 from ciprofloxacin/metronidazole to rifaximin for gut decontamination on intestinal microbiota composition and ASCT outcome, we retrospectively analyzed 394 patients receiving ASCT from September 2008 through June 2015. In 131 and 90 patients, respectively, urinary 3-indoxyl sulfate levels and intestinal enterococcal load were measured before conditioning and weekly within the first 28 days after ASCT. The use of rifaximin correlated with lower enterococcal positivity (6.9 vs 21.9%, P=0.05) and higher urinary 3-indoxyl sulfate concentrations (10.5 vs 4.6 µmoL/mmoL crea, P<0.001) after ASCT. Patients on rifaximin showed lower 1-year transplant-related mortality (P=0.04) and higher overall survival (P=0.008). Treatment of infectious complications with systemic antibiotics did not abrogate the beneficial effects of rifaximin on intestinal microbiota composition in the early course of ASCT and outcome. The data underscore the importance of maintaining a diverse population of symbiotic and mutualistic bacteria in the gut on ASCT outcome.
Subject(s)
Gastrointestinal Microbiome/drug effects , Hematopoietic Stem Cell Transplantation/methods , Rifamycins/administration & dosage , Adult , Enterococcus/drug effects , Female , Gastrointestinal Diseases/prevention & control , Graft vs Host Disease/microbiology , Hematopoietic Stem Cell Transplantation/adverse effects , Hematopoietic Stem Cell Transplantation/mortality , Humans , Indican/analysis , Male , Middle Aged , Retrospective Studies , Rifamycins/pharmacology , Rifaximin , Survival Analysis , Transplantation, HomologousABSTRACT
Head trauma is exceedingly common in children, but rarely presents as a penetrating injury to the skull. Most of the recommendations on evaluation, management, and follow-up of such injuries are based on the adult literature. We report a case of penetrating head injury from a tapered metal object in a 4-year old child.
