Sex-specific associations between childhood trauma and adult systemic inflammation in daily life.

OBJECTIVE: Childhood trauma may contribute to lifelong health through chronic systemic inflammation. However, associations between childhood trauma and inflammation are mixed, indicating that distinct types of childhood trauma may relate to inflammation differently. Moreover, most studies use a single assessment of inflammatory markers that may not reliably estimate stable interindividual differences. The current study is the first to examine relationships between childhood trauma and an ecologically valid measure of inflammation derived from repeated assessments of interleukin (IL)-6 in daily life. We also examine the possibility that glucocorticoid sensitivity and patterns of daily cortisol may contribute to observed associations. Finally, we explore whether biological sex moderates relationships between childhood trauma and IL-6. METHOD: Participants were 283 healthy adults aged 40-64 (57% female, 23% Black, Indigenous, and People of Color) who completed the Childhood Trauma Questionnaire and self-collected dried blood spots at home on 4 days to measure IL-6. Measures of salivary cortisol and blood-based glucocorticoid sensitivity were also assessed. RESULTS: Childhood trauma was not associated with IL-6 in the sample as a whole. However, exploratory analyses showed that childhood trauma related to IL-6 differently for males and females, such that total trauma and emotional neglect predicted higher IL-6 for males but not females. Results persisted after adjustment for covariates. There was no evidence for indirect effects via cortisol or glucocorticoid sensitivity. CONCLUSIONS: Childhood trauma and, specifically, emotional neglect were associated with IL-6 in daily life among middle-aged males. Additional research is needed to elucidate biological and behavioral pathways underlying these associations. (PsycInfo Database Record (c) 2024 APA, all rights reserved).

Adults Older Than Age 55 Engage in Less Diverse Activities Than Those 18 Years Ago.

OBJECTIVES: Life-span perspectives have long acknowledged that individual functioning is shaped by historical and sociocultural contexts. Secular increases favoring recent cohorts are widely documented. However, little is known about secular trends in day-to-day activities and whether historical changes have occurred in younger and older adults alike. METHODS: We compared data from 2 independent cohort samples of the daily diary portion of the Midlife in the United States Study obtained 18 years apart (1995/1996 cohort: n = 1,499 vs 2013/2014 cohort: n = 782) and identified case-matched cohorts (n = 757 per cohort) based on age, gender, education, and race. An activity diversity score was calculated based on 7 common daily activities, using Shannon's entropy method. We additionally examined the roles of age and other sociodemographic and health characteristics in cohort differences in activity diversity. RESULTS: Results revealed that the 2013/2014 cohort experienced lower daily activity diversity than the 1995/1996 cohort. Age was positively associated with activity diversity in the 1995/1996 cohort, whereas age was negatively associated with activity diversity in the 2013/2014 cohort. These associations were significant for those who were older than age 55. Cohorts also differed in the types of most dominant activities and average time spent on those activities. DISCUSSION: Findings show changes in the lifestyles and daily activities of U.S. adults across 2 decades. Contrasting to the common belief that today's adults may be healthier and more active, they seem engaging in less diverse daily activities, which can be a risk for future health outcomes.

Psychosocial impacts of the COVID-19 pandemic on women with trauma histories: Study of Women's Health Across the Nation (SWAN).

Older adults, particularly those with trauma histories, may be vulnerable to adverse psychosocial outcomes during the COVID-19 pandemic. We tested associations between prepandemic childhood abuse or intimate partner violence (IPV) and elevated depressive, anxiety, conflict, and sleep symptoms during the pandemic among aging women. Women (N = 582, age: 65-77 years) from three U.S. sites (Pittsburgh, Boston, Newark) of the longitudinal Study of Women's Health Across the Nation (SWAN) reported pandemic-related psychosocial impacts from June 2020-March 2021. Prepandemic childhood abuse; physical/emotional IPV; social functioning; physical comorbidities; and depressive, anxiety, and sleep symptoms were drawn from SWAN assessments between 2009 and 2017. There were no measures of prepandemic conflict. In total, 47.7% and 35.3% of women, respectively, reported childhood abuse or IPV. Using logistic regression models adjusted for age; race/ethnicity; education; site; prepandemic social functioning and physical comorbidities; and, in respective models, prepandemic depressive, anxiety, or sleep symptoms, childhood abuse predicted elevated anxiety symptoms, OR = 1.67, 95% CI [1.10, 2.54]; household conflict, OR = 2.19, 95% CI [1.32, 3.61]; and nonhousehold family conflict, OR = 2.14, 95% CI [1.29, 3.55]. IPV predicted elevated sleep problems, OR = 1.63, 95% CI [1.07, 2.46], and household conflict, OR = 1.96, 95% CI [1.20, 3.21]. No associations emerged for depressive symptoms after adjusting for prepandemic depression. Aging women with interpersonal trauma histories reported worse anxiety, sleep, and conflict during the COVID-19 pandemic than those without. Women's trauma histories and prepandemic symptoms are critical to understanding the psychosocial impacts of the pandemic.

A Longitudinal Study of Age-Based Change in Blood Pressure Reactivity and Negative Affect Reactivity to Natural Stressors.

OBJECTIVE: Aging is theoretically accompanied by emotional gains, but physiological self-regulatory losses. Emotional and physiological regulation can be operationalized as the extent of an increase in negative affect and blood pressure upon experiencing a stressor (i.e., reactivity). The direction of age-based changes in negative affect reactivity to stressors is uncertain. In addition, evidence for age-based increases in blood pressure reactivity to stressors is based largely on age-based differences observed in cross-sectional and laboratory-based studies. The present study is the first to examine long-term longitudinal changes in stress-related reactivity for both blood pressure and negative affect in the natural environment. METHODS: A total of 375 healthy adults aged 50 to 70 years completed 6 days of hourly ambulatory blood pressure assessment and electronic diary reports of social conflict and task demand and control. Two hundred fifty-five participants repeated 3 days of assessment in a 6-year follow-up. With reactivity operationalized as the change in an outcome in association with momentary social conflict, task strain, or task demand (i.e., a model-derived slope parameter), multilevel models were used to assess aging-based change in blood pressure and negative affect reactivity over the course of the 6-year follow-up. RESULTS: Aging is associated with increased diastolic blood pressure reactivity to social conflict and task demand (ßsocial_conflict = 0.48, p = .007; ßtask_demand = 0.19, p = .005), increases in negative affect reactivity to social conflict and task strain (ßsocial_conflict = 0.10, p < .001; ßtask_strain = 0.08, p = .016), and increases in systolic blood pressure reactivity to task-based stress (ßtask_strain = 1.29, p = .007; ßtask_demand = 0.23 p = .032). CONCLUSION: Findings suggest age-based increases in affective and cardiovascular reactivity to natural stressors.

Sleep and Daily Social Experiences as Potential Mechanisms Linking Social Integration to Nocturnal Blood Pressure Dipping.

OBJECTIVE: Socially integrated individuals are at lower risk of cardiovascular disease morbidity and mortality compared with their more isolated counterparts. This association may be due, in part, to the effect of social integration on nocturnal blood pressure (BP) decline or "dipping," a physiological process associated with decreased disease risk. However, the pathways linking social integration with nocturnal BP dipping are unknown. We sought to replicate the association between social integration and BP dipping, and to test whether sleep characteristics (duration, regularity, continuity) and/or daily social interactions (frequency, valence) helped to explain the association. METHODS: A total of 391 healthy midlife adults completed an actigraphy assessment protocol that measured sleep. During four actigraphy assessment days, participants also completed ambulatory BP monitoring and ecological momentary assessment protocols that measured BP and social interactions at regular intervals throughout the day. Social integration was assessed via a questionnaire. RESULTS: Linear regression controlling for age, sex, race, education, and body mass index indicated that higher levels of social integration were associated with greater nocturnal BP dipping, as indicated by a smaller ratio of night/day mean arterial pressure (ß = -0.11, p = .031). Analyses of indirect effects suggested that this association was explained, in part, by greater sleep regularity among more integrated individuals. We did not find evidence for other hypothesized indirect effects. CONCLUSIONS: This was the first study to investigate sleep and social mechanisms underlying the link between social integration and nocturnal BP dipping. Because sleep regularity is modifiable, this pathway represents a potential intervention target to promote nocturnal BP dipping.

Control diversity: How across-domain control beliefs are associated with daily negative affect and differ with age.

Domain-specific control beliefs typically buffer the influence stressors have on people's negative affect (affective stressor reactivity). However, little is known about the extent to which individuals' control beliefs vary across stressor types and whether such stressor-related control diversity is adaptive for affective well-being. We thus introduce a control diversity construct (a person-level summary of across-domain control beliefs) and examine how control diversity differs with age and relates to negative affect and affective stressor reactivity. We apply a multilevel model to daily diary data from the National Study of Daily Experiences (NSDE; N = 2,022; mean age = 56 years; 33-84; 57% women). Our findings indicate that above and beyond average control beliefs, people whose control is spread over fewer stressor domains (less control diversity) have lower negative affect and less affective stressor reactivity. Older adults are more likely than younger adults to have their control beliefs concentrated in one domain. Additionally, associations between control diversity and negative affect and affective stressor reactivity were age invariant. Moderation effects indicated that when people with low average control beliefs are faced with stressors, having control beliefs focused on fewer domains rather than spread broadly across many domains is associated with less negative affect. Our findings suggest that control diversity provides unique insights into how control beliefs differ across adulthood and contribute to affective well-being. (PsycINFO Database Record (c) 2019 APA, all rights reserved).

Self-Reported Everyday Psychosocial Stressors Are Associated With Greater Impairments in Endothelial Function in Young Adults With Major Depressive Disorder.

Background Despite the epidemiological associations between psychological stress, depression, and increased cardiovascular disease risk, no studies have examined the relation between naturally occurring psychosocial stressors and directly measured microvascular function in adults with major depressive disorder ( MDD ). We tested the hypothesis that young adults with MDD exposed to everyday psychosocial stressors would exhibit more severe impairments in endothelium-dependent dilation ( EDD ) compared with: (1) healthy nondepressed adults ( HCs ); and (2) adults with MDD without acute psychosocial stress exposure. Methods and Results Twenty HCs (22±1 years) and 23 otherwise healthy adults with MDD (20±0.3 years) participated in the study. Participants completed a psychosocial experiences survey to document their exposure to any of 6 stressors over the preceding 24 hours (eg, arguments, work stressors). Red cell flux (laser Doppler flowmetry) was measured during graded intradermal microdialysis perfusion of acetylcholine (10-10 to 10-1mol/L). EDD was expressed as a percentage of maximum vascular conductance (flux/mm Hg). Multiple linear regression was used to determine the associations between stress, EDD , and MDD . Adults with MDD reported a greater number and severity of psychosocial stressors compared with HCs (all P<0.05). EDD was blunted in adults with MDD ( HCs : 91±2 versus MDD : 74±3%; P<0.001). Exposure to any stressor was related to more severe impairments in EDD in patients with MDD (no stressor: 81±3 versus 1+ stressors: 69±5%; P=0.04) but not in HCs ( P=0.48). Conclusions These data indicate that exposure to everyday psychosocial stressors is associated with greater impairments in endothelial function in patients with MDD , suggesting a potential mechanistic link between daily stress and depression in increased cardiovascular risk.

The Role of General and Daily Control Beliefs for Affective Stressor-Reactivity Across Adulthood and Old Age.

BACKGROUND: General and situational control beliefs have been examined separately as buffers of the effects of daily stressors on affective well-being. However, general (trait) control beliefs reflect perceived ability to adapt, change, and influence overall life circumstances, whereas situational (daily) control beliefs reflect perceived ability to manage current circumstances and achieve desired outcomes. METHOD: Using 9 weeks of daily reports from 150 adults aged 18-89 years, we examined the extent that general and daily control beliefs buffer the between- and within-person associations involving stressors and negative and positive affect (i.e., daily stress processes) and whether/how the extent of buffering differs with age. RESULTS: Aligning with prior findings, both greater average stressor exposure and experiencing a daily stressor compromised daily affective well-being and both higher general and daily control beliefs facilitated daily affective well-being. Specific to the motivating hypotheses, both general and daily control beliefs buffered daily stressor-reactivity. Age was associated with individuals' daily stressor-buffering, such that stressor-reactivity was more effectively damped at older ages. Associations between general control beliefs and daily stress processes were age invariant. DISCUSSION: Mixed evidence of age differences across general and daily control beliefs highlights how within-person processes may differentially contribute to well-being as individuals accommodate age-related strengths and vulnerabilities.

Activity Diversity and Its Associations With Psychological Well-Being Across Adulthood.

Objectives: This study examined age-related cross-sectional and longitudinal associations between activity diversity and four dimensions of well-being: psychological well-being, depression, positive affect, and negative affect. Method: Activity diversity was defined as the breadth and evenness of participation in seven daily activities including paid work, time with children, doing chores, leisure, physical activities, formal volunteering, and giving informal help to others. Participants from the National Survey of Daily Experiences (N = 793, Mage = 46.71, SDag = 12.48) provided data during two 8-day measurement bursts approximately 10 years apart. Results: Older adults (age = 60-74 years) who engaged in more diverse activities reported higher psychological well-being than older adults who engaged in less diverse activities; an association not significant among middle-aged adults (age = 35-59 years), and in the opposite direction for younger individuals (age = 24-34 years). Longitudinally, increased activity diversity over 10 years was marginally associated with increases in positive affect. Compared with younger individuals who increased activity diversity, older adults who increased activity diversity reported smaller decreases in psychological well-being, greater increases in positive affect, and greater decreases in negative affect. Discussion: Our findings suggest that activity diversity may play an important role in older adults' concurrent well-being and also in their long-term longitudinal improvements of well-being.

More than Counting: An Intraindividual Variability Approach to Categorical Repeated Measures.

Objectives: Age-related differences in daily experiences are often described using summaries of categorical repeated measures, including typologies of stressors, activities, social partners, and coping strategies. This paper illustrates how an intraindividual variability (IIV) framework can be used to extract additional meaning from categorical IIV data. Method: Using 8-occasion categorical data on daily stressors from the National Study of Daily Experiences (N = 1,499, MAge = 46.74, SDAge= 12.91), we derive and compute six IIV metrics that invoke numeric and nominal measurement of the central tendency, dispersion, and asymmetry of individuals' stressor experiences and examine how these metrics, relative dominance, diversity, log-skew and mode, spread, order, are related to age and interindividual differences in negative affect. Results: Results demonstrate the utility of the numeric and nominal categorical IIV metrics, with theoretically meaningful age gradients in the three numeric IIV stressor metrics and five of six IIV metrics mapping differences in negative affect. Discussion: Findings highlight how the unique constructs measured by these six metrics of categorical IIV may be used to examine dynamic process, study interindividual and age-related differences, and expand the variety of developmental research questions that may be answered using categorical repeated measures data.

Feature Selection Methods for Optimal Design of Studies for Developmental Inquiry.

Objectives: As diary, panel, and experience sampling methods become easier to implement, studies of development and aging are adopting more and more intensive study designs. However, if too many measures are included in such designs, interruptions for measurement may constitute a significant burden for participants. We propose the use of feature selection-a data-driven machine learning process-in study design and selection of measures that show the most predictive power in pilot data. Method: We introduce an analytical paradigm based on the feature importance estimation and recursive feature elimination with decision tree ensembles and illustrate its utility using empirical data from the German Socio-Economic Panel (SOEP). Results: We identified a subset of 20 measures from the SOEP data set that maintain much of the ability of the original data set to predict life satisfaction and health across younger, middle, and older age groups. Discussion: Feature selection techniques permit researchers to choose measures that are maximally predictive of relevant outcomes, even when there are interactions or nonlinearities. These techniques facilitate decisions about which measures may be dropped from a study while maintaining efficiency of prediction across groups and reducing costs to the researcher and burden on the participants.

Stressor diversity: Introduction and empirical integration into the daily stress model.

The present study examined whether and how stressor diversity, the extent to which stressor events are spread across multiple types of stressors, contributes to daily affective well-being through the adult life span. Stressor diversity was examined as a unique predictor of daily affect and as a moderator of stressor exposure and stressor reactivity effects. Analyses span 2 independent studies of daily stress: the National Study of Daily Experiences with N = 2,022 adults, aged 33 to 85 years, assessed over T = 8 days, and the Intraindividual Study of Affect, Health, and Interpersonal Behavior with N = 150 adults, aged 18 to 89 years, assessed over T = 63 days. Across both studies, older age was associated with less stressor diversity. Additionally, multivariate multilevel models indicated higher stressor diversity was linked with better affective well-being. Age, however, was not a consistent moderator of such associations. The combination of low stressor diversity and high stressor exposure is discussed as an operationalization of chronic stressors, and this combination was associated with particularly high negative affect and low positive affect. We believe further work will benefit from including both the frequency and diversity of stressor experiences in analyses in order to better characterize individuals' stressor experiences. (PsycINFO Database Record