ABSTRACT
The synthesis of a dicationic imidazolium-linked cyclophane and a dimeric silver-N-heterocyclic carbene complex, that is the first silver complex with a N-heterocyclic carbene ligand involved in a pi-bonding interaction, is reported.
ABSTRACT
Screening tests for genetic metabolic diseases remain extremely useful due to their rapidity, ease of interpretation and substantial reduction of cost. However, interferences in these tests are still a source of concern in laboratory medicine. Cost considerations have so compressed the duration of the medical work-up that the administration of radiologic contrast may often antedate the collection of body fluids for genetic-metabolic testing. It has been found that under these circumstances, certain contrast media may interfere with the urinary studies of amino acids, organic acids, and tests involving ultraviolet absorption such as those concerned with purines, pyrimidines, and related compounds. The consequences of interference may be misdiagnosis, repeated testing, extensive and expensive work-ups, and unnecessary delay and anxiety for the family. As in all testing, it is prudent to avoid medications and atypical diets, if possible. In the case of contrast media, it is a simple matter to collect samples for analysis prior to the administration of radiocontrast so as to avoid the pitfalls and yet not delay the diagnostic work-up.
Subject(s)
Contrast Media/adverse effects , Genetic Testing/methods , Metabolism, Inborn Errors/diagnosis , Artifacts , Chromatography, Paper , Electrophoresis, Polyacrylamide Gel , Genetic Testing/standards , Humans , Metabolism, Inborn Errors/urine , Spectrum AnalysisSubject(s)
Cephalosporins/urine , Metabolism, Inborn Errors/diagnosis , Cefaclor/urine , Cephalosporins/chemistry , Chromatography, Paper/statistics & numerical data , Electrophoresis, Paper/statistics & numerical data , False Positive Reactions , Humans , Molecular Structure , Ninhydrin , Staining and LabelingSubject(s)
AIDS-Related Opportunistic Infections/drug therapy , Acquired Immunodeficiency Syndrome/urine , Pyrimethamine/therapeutic use , Sulfadiazine/analogs & derivatives , Sulfadiazine/urine , Toxoplasmosis, Cerebral/drug therapy , Urinary Calculi/chemistry , AIDS-Related Opportunistic Infections/urine , Adult , Hemophilia A , Humans , Male , Sulfadiazine/therapeutic use , Toxoplasmosis, Cerebral/complications , Toxoplasmosis, Cerebral/urine , Urinary Calculi/chemically inducedABSTRACT
An acute cyanotic episode due to methemoglobinemia occurred in a 16-month old girl following the ingestion of N,N-dimethyl-p-toluidine, a commercially available component used in the production of artificial fingernails. The amount of the parent compound ingested was about 6 mg/kg of body weight. Administration of methylene blue was effective in the reversal of the methemoglobinemia. In vitro studies suggest that the activity of the compound was probably due to its biochemical transformation to the toxic metabolite p-methylphenylhydroxylamine. We expand the list of aromatic amino or nitro compounds and their derivatives capable of producing methemoglobinemia and call attention to the hazard of their ingestion.