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Chem Pharm Bull (Tokyo) ; 56(5): 692-4, 2008 May.
Article in English | MEDLINE | ID: mdl-18451560

ABSTRACT

Silver loaded zeolite (Ag-Z) was previously found to have effective bactericidal activity against Escherichia coli. To understand the mechanisms of bactericidal activity of Ag-Z, role of light irradiation was focused and investigated in this study. In this study, we focused on light irradiation. Antibacterial assay and spectroscopic study revealed that light irradiation enabled Ag-Z to reduce dioxygen to form a reactive oxygen species, which led to bactericidal activity. These results indicate that the onset of bactericidal activity can be controlled by light irradiation.


Subject(s)
Anti-Bacterial Agents/pharmacology , Anti-Bacterial Agents/radiation effects , Bacteria/drug effects , Bacteria/radiation effects , Silver/pharmacology , Silver/radiation effects , Zeolites/pharmacology , Zeolites/radiation effects , Anti-Bacterial Agents/chemistry , Bacteria/enzymology , Colony Count, Microbial , Cytochromes c/metabolism , Electron Spin Resonance Spectroscopy , Escherichia coli/drug effects , Escherichia coli/radiation effects , Light , Oxygen/chemistry , Oxygen/radiation effects , Reactive Oxygen Species/metabolism , Silver/chemistry , Spectrophotometry, Ultraviolet , Zeolites/chemistry
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