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1.
Clin Infect Dis ; 2024 Feb 05.
Article in English | MEDLINE | ID: mdl-38315890

ABSTRACT

BACKGROUND: Carbapenemase-producing, carbapenem-resistant Pseudomonas aeruginosa (CP-CRPA) are extensively drug resistant bacteria. We investigated the source of a multistate CP-CRPA outbreak. METHODS: Cases were defined as a U.S. patient's first isolation of P. aeruginosa sequence type 1203 with the carbapenemase gene blaVIM-80 and cephalosporinase gene blaGES-9 from any specimen source collected and reported to CDC between January 1, 2022-May 15, 2023. We conducted a 1:1 matched case-control study at the post-acute care facility with the most cases, assessed exposures associated with case status for all case-patients, and tested products for bacterial contamination. RESULTS: We identified 81 case-patients from 18 states, 27 of whom were identified through surveillance cultures. Four (7%) of 54 case-patients with clinical cultures died within 30 days of culture collection, and four (22%) of 18 with eye infections underwent enucleation. In the case-control study, case-patients had increased odds of receiving artificial tears compared to controls (crude matched OR: 5.0, 95% CI: 1.1, 22.8). Overall, artificial tears use was reported by 61 (87%) of 70 case-patients with information; 43 (77%) of 56 case-patients with brand information reported use of Brand A, an imported, preservative-free, over-the-counter (OTC) product. Bacteria isolated from opened and unopened bottles of Brand A were genetically related to patient isolates. FDA inspection of the manufacturing plant identified likely sources of contamination. CONCLUSIONS: A manufactured medical product serving as the vehicle for carbapenemase-producing organisms is unprecedented in the U.S. The clinical impacts from this outbreak underscore the need for improved requirements for U.S. OTC product importers.

2.
Infect Control Hosp Epidemiol ; 43(3): 351-357, 2022 03.
Article in English | MEDLINE | ID: mdl-33736719

ABSTRACT

OBJECTIVE: To describe a pilot project infection prevention and control (IPC) assessment conducted in skilled nursing facilities (SNFs) in New York State (NYS) during a pivotal 2-week period when the region became the nation's epicenter for coronavirus disease 2019 (COVID-19). DESIGN: A telephone and video assessment of IPC measures in SNFs at high risk or experiencing COVID-19 activity. PARTICIPANTS: SNFs in 14 New York counties, including New York City. INTERVENTION: A 3-component remote IPC assessment: (1) screening tool; (2) telephone IPC checklist; and (3) COVID-19 video IPC assessment (ie, "COVIDeo"). RESULTS: In total, 92 SNFs completed the IPC screening tool and checklist: 52 (57%) were conducted as part COVID-19 investigations, and 40 (43%) were proactive prevention-based assessments. Among the 40 proactive assessments, 14 (35%) identified suspected or confirmed COVID-19 cases. COVIDeo was performed in 26 (28%) of 92 assessments and provided observations that other tools would have missed: personal protective equipment (PPE) that was not easily accessible, redundant, or improperly donned, doffed, or stored and specific challenges implementing IPC in specialty populations. The IPC assessments took ∼1 hour each and reached an estimated 4 times as many SNFs as on-site visits in a similar time frame. CONCLUSIONS: Remote IPC assessments by telephone and video were timely and feasible methods of assessing the extent to which IPC interventions had been implemented in a vulnerable setting and to disseminate real-time recommendations. Remote assessments are now being implemented across New York State and in various healthcare facility types. Similar methods have been adapted nationally by the Centers for Disease Control and Prevention.


Subject(s)
COVID-19 , COVID-19/prevention & control , Humans , Infection Control/methods , New York City/epidemiology , Nursing Homes , Pilot Projects , SARS-CoV-2
3.
J Med Entomol ; 43(5): 924-35, 2006 Sep.
Article in English | MEDLINE | ID: mdl-17017230

ABSTRACT

Intensive small mammal trapping was conducted in 12 counties in New York state during 1998-2000 to investigate the prevalence and site specificity of the Lyme disease spirochete, Borrelia burgdorferi in, and presence of the blacklegged tick, Ixodes scapularis Say on, the wild mice Peromyscus leucopus Rafinesque and Peromyscus maniculatus Wagner and other small mammal species. Previously captured mice (1992-1997) from throughout New York state also were recruited into the study, providing a total of 3,664 Peromyscus from 107 sites in 31 counties. Infection with B. burgdorferi was determined by polymerase chain reaction testing of ear tissue, and rates were determined by species, counties, and regions of the state. B. burgdorferi was detected in 10 small mammal species captured during 1998-2000. Peromyscus captured from Dutchess County in the lower Hudson Valley had the highest infection rate of 21%. The next highest infection rates were in counties within the Capital District: Albany (18%), Rensselaer (17%), and Columbia (13%). From 4,792 small animals examined, we recovered 2,073 ticks representing six species from 414 individuals of 12 mammal species, including 1,839 I. scapularis collected from 315 Peromyscus trapped in five counties. I. scapularis were most often collected from animals trapped in Albany, Rensselear, and Dutchess counties. We used protein electrophoresis of salivary amylase to distinguish between P. leucopus and P. maniculatus species. I. scapularis burdens were 5.7 ticks per P. leucopus and 14.3 ticks per P. maniculatus.


Subject(s)
Borrelia burgdorferi/isolation & purification , Lyme Disease/veterinary , Peromyscus/microbiology , Rodent Diseases/epidemiology , Animals , Antigens, Surface/genetics , Arvicolinae/microbiology , Arvicolinae/parasitology , Bacterial Outer Membrane Proteins/genetics , Bacterial Vaccines/genetics , DNA Primers/chemistry , Disease Reservoirs/microbiology , Ixodidae/classification , Ixodidae/microbiology , Lipoproteins/genetics , Lyme Disease/epidemiology , Mice , New York/epidemiology , Peromyscus/parasitology , Polymerase Chain Reaction/methods , Prevalence , Rodent Diseases/microbiology , Shrews/microbiology , Shrews/parasitology , Tick Infestations/epidemiology , Tick Infestations/microbiology , Tick Infestations/veterinary , Time Factors
4.
J Med Entomol ; 42(4): 694-6, 2005 Jul.
Article in English | MEDLINE | ID: mdl-16119561

ABSTRACT

A rapid and sensitive protocol using Chelex 100 resin for DNA extraction and the polymerase chain reaction for detection of Babesia microti Franca within its vector Ixodes scapularis Say is described. The level of detection of this protocol was determined to be the approximate equivalent of one parasite.


Subject(s)
Babesia microti/genetics , DNA, Protozoan/analysis , Ixodes/parasitology , Polymerase Chain Reaction/methods , Animals , Arachnid Vectors/parasitology , Chelating Agents , Mice , Resins, Synthetic
5.
Emerg Infect Dis ; 11(3): 476-8, 2005 Mar.
Article in English | MEDLINE | ID: mdl-15757571

ABSTRACT

Five cases of human babesiosis were reported in the Lower Hudson Valley Region of New York State in 2001. An investigation to determine if Babesia microti was present in local Ixodes scapularis ticks yielded 5 positive pools in 123 pools tested, the first detection of B. microti from field-collected I. scapularis in upstate New York.


Subject(s)
Arachnid Vectors/parasitology , Babesia microti/isolation & purification , Ixodes/parasitology , Animals , Babesia microti/genetics , Babesiosis/epidemiology , Humans , Molecular Sequence Data , New York/epidemiology
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