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1.
Med Hypotheses ; 56(6): 598-607, 2001 Jun.
Article in English | MEDLINE | ID: mdl-11399106

ABSTRACT

The general hypothesis that quantum mechanics (QM) and thermodynamic concepts relate to biological systems is discussed and applied to the biological influence of: (1) electromagnetic fields (EMFs); and (2) EMFs that have been exposed to human intention. We illustrate our hypothesis with experiments involving four simultaneous treatments: exposure to ambient EMFs in the laboratory environment (C), exposure in a Faraday cage (F) and exposure in a Faraday cage with either: (i) an electronic device (IIED) which had been exposed to a specific human intention (d,j); or (ii) a non-exposed, physically identical, device (d,o). Experimental systems were fitness and energy metabolism in Drosophila melanogaster, in vitro enzyme activity and molecular concentration variability over time. Results indicated that shielding from ambient EMFs via a Faraday cage (F) made a significant difference relative to the unshielded control (C). Further, (d,o) had a significant lowering effect in the shielded environment. Finally, there was a strong 'intention' effect with the IIED (d,j) producing significant and positive effects in comparison to (d,o) in each experimental system.


Subject(s)
Electromagnetic Fields , Mental Processes , Quantum Theory , Semiconductors , Adenosine Diphosphate/metabolism , Adenosine Triphosphate/metabolism , Alkaline Phosphatase/metabolism , Animals , Drosophila melanogaster/enzymology , Drosophila melanogaster/growth & development , Drosophila melanogaster/metabolism , Drosophila melanogaster/physiology , Energy Metabolism , Humans , NAD/metabolism , Thermodynamics
2.
Integr Physiol Behav Sci ; 35(2): 142-62; discussion 163, 2000.
Article in English | MEDLINE | ID: mdl-11021339

ABSTRACT

Although quantum mechanics allows consciousness to have some effect on the collapse of wave functions, most conventional scientists expect the effect to be quite small. Their experience with expert systems, computer-aided design, etc., would cause them to deny the possibility that a specific human intention could be imprinted into a simple electronic device via a meditative process and that this device could then influence a target experiment in accordance with the specific intention. Here, via two very different target experiments, that prevailing supposition has been experimentally tested and found to be fallacious! For each target experiment, one starts with two identical physical devices, isolates them from each other and "charges" one with the specific intention for the particular experiment. This charging process involved the services of four highly qualified meditators to imprint the device with the specific intention. The devices were then wrapped in aluminum foil and separately shipped, via Federal Express approximately 2,000 miles to a laboratory where the actual target experiments were conducted by others. For the two experiments, the intentions were (1) to decrease (increase) the pH of water by one pH unit and (2) to increase the ATP/ADP ratio in fruit fly larvae so as to significantly decrease their development time. For (1), changes of 0.5 to 1.0 pH units were achieved while, for (2), reductions of approximately 15 percent in larval development time for the imprinted vs. unimprinted device were observed (p<0.005). From a theoretical perspective, (1) a thermodynamic basis is provided for the effect of intention on both the electrochemical potential and flux of molecular species, (2) a conceptual model for linking subtle domains with the physical domain devices is given, and (3) a conceptual model is also given of how such devices may broadcast specific prime directive information via intention-augmented electromagnetism which can "tilt" chemical reactions in appropriate ways within the target experiment.


Subject(s)
Artificial Intelligence , Consciousness , Electronics , Adenosine Diphosphate/metabolism , Adenosine Triphosphate/metabolism , Animals , Crystallization , Drosophila , Humans , Hydrogen-Ion Concentration , Larva/growth & development , Models, Neurological , Thermodynamics , Water/chemistry
3.
J Exp Biol ; 202(Pt 22): 3145-54, 1999 Nov.
Article in English | MEDLINE | ID: mdl-10539963

ABSTRACT

We study here the connections among body temperature variation, flight performance and flight 'fuel' metabolism in Colias eurytheme butterflies, to begin re-examining the metabolic reasons for animal thermoregulation. Methods are presented for (a) stable extraction of adenylates (and other metabolites) from the flight muscles of individual Colias eurytheme, (b) automated separation and quantitative analysis of individual adenylate samples by high-pressure liquid chromatography and (c) reliable, low-variance assay of inorganic phosphate levels in the same extracts. Correlations among metabolite concentrations and two indices of muscle cytosol ATP maintenance occur as expected on general metabolic principles. [ATP] and [ATP]/[ADP] decline from resting levels to reach a plateau in the first minute of free, interrupted flight, while [AMP] increases at the same time; these concentrations do not vary further for up to 6 min total flight time. In an initial test of the alternative metabolic bases of the thermoregulation of Colias eurytheme, we find that [ATP]/[ADP] rises between a body temperature, T(b), of 31 and 35 degrees C, at the base of the behavioral thermal optimum for flight, but then decreases again at T(b)=39 degrees C, at the top of the behavioral thermal optimum and well short of damaging temperatures. This is not consistent with the view that metabolic effectiveness increases monotonically up to the lower limits of thermal damage to enzymes, but supports an alternative hypothesis that the narrowness of thermoregulation results from a system-based constraint on the breadth of temperature over which maximal energy processing is possible.


Subject(s)
Body Temperature Regulation , Flight, Animal , Lepidoptera/physiology , Muscle, Skeletal/metabolism , Adenine Nucleotides/metabolism , Adenosine Diphosphate/metabolism , Adenosine Triphosphate/metabolism , Animals
4.
Proc Biol Sci ; 257(1349): 185-91, 1994 Aug 22.
Article in English | MEDLINE | ID: mdl-7972164

ABSTRACT

Perturbation of energy metabolism via NAD supplementation modifies the expression of larval development time, a genetically based trait relevant to development and whole-organism fitness in Drosophila melanogaster. The results suggest a link between energy metabolism and gene expression. Supplemental NAD significantly decreased larval development time for isofemale strains chosen on the basis of development time differences. This effect did not represent a trade-off with larval survival, and was not related to the effects of supplemental glucose. The isofemale strains were assayed by using a method derived from Warburg's manometric procedures which measured changes in the proportions of ATP, ADP and AMP in larval homogenates. Supplemental NAD appeared to increase the proportion of ATP and the [ATP]/[ADP] ratio in vitro and during larval development. The decrease in larval development time mediated by NAD was attributed to supplemental NAD modifying the NAD pool beyond levels established during development, directly altering electron transport chain activity, ATP, ADP and AMP levels, and possibly gene expression.


Subject(s)
Drosophila melanogaster/metabolism , Adenine Nucleotides/metabolism , Animals , Azides/pharmacology , Drosophila melanogaster/genetics , Drosophila melanogaster/growth & development , Energy Metabolism/drug effects , Female , Gene Expression Regulation, Developmental/drug effects , Glucose/pharmacology , Larva/drug effects , Larva/growth & development , NAD/pharmacology , Sodium Azide
5.
Heredity (Edinb) ; 60 ( Pt 2): 273-81, 1988 Apr.
Article in English | MEDLINE | ID: mdl-3130341

ABSTRACT

This paper reports some effects of temperature variation, nutritional stress and a novel alteration in energy availability upon larval fitness in Drosophila melanogaster. The cofactor nicotinamide adenine dinucleotide (NAD) has been chosen as a novel energy source to be supplemented in food during larval development. The effects have been assessed at the phenotypic level for larval survival and development time and at the genotypic level for the alcohol dehydrogenase (Adh) and glycerol-3-phosphate dehydrogenase (Gpdh) loci. Supplemented NAD was found to increase survival at the lower temperatures and decrease survival at the higher temperatures. Further, for each temperature, NAD decreased development time although this effect diminished as temperature increased. There were no significant effects at the genotypic level. Hence a phenotypic approach studying the effects of environmental stresses and novel energy availability may be useful in understanding fitness variation in Drosophila populations.


Subject(s)
Drosophila melanogaster/physiology , Animals , Drosophila melanogaster/genetics , Energy Metabolism , Genetic Variation , Larva/physiology , NAD/metabolism , Stress, Physiological , Temperature
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