ABSTRACT
The aim of this overview was to outline the pathophysiology, common comorbidities and current therapeutic modalities in the treatment/management of restless legs syndrome (RLS) a sensorimotor neurological disorder. The main symptom in RLS is a compelling compulsion to move the legs and a sense of restlessness at rest most commonly occurring during the night and improving with movement. The prevalence of secondary RLS among comorbid conditions such as idiopathic pulmonary fibrosis, end-stage renal disease, irritable bowel syndrome and attention deficit/hyperactivity disorder have further elucidated our understanding of the role of the iron-dopamine hypothesis as an etiopathogenetic hallmark in RLS and the efficacy of therapeutic approaches in milder to more severe forms. Currently, RLS treatment uses only symptomatic agents, since a disease-modifying therapy does not yet exist. The phenomena of rebound and augmentation have become central phenomena in overcoming the pharmacotherapeutic challenges when treating with dopaminergic agents in RLS. Considering alternative nonpharmacological therapies, especially for the treatment of RLS in pregnancy has a significant role and positive clinical outcome for patients in controlling symptoms.
ABSTRACT
A comprehensive review of the body of genetic studies on schizophrenia seems even more daunting than the battle a psychiatrist wages daily in the office with her archenemy of a thousand faces. The following article reunites some genetic, epigenetic and environmental factors of schizophrenia from revered and vast studies in a chronological and progressive fashion. Twin studies set the basics of heritability and a particular study by Davis and Phelps considers the widely ignored influence of prenatal environment in the development of schizophrenia. Mostly ignited by linkage studies, candidate gene studies explore further by fine-mapping the hypothesized variants [mostly in the forms single nucleotide polymorphisms (SNPs) and less but with greater impact copy number variations (CNVs)] associated with the disease. Genome-wide association studies (GWAS) increase considerably the sample sizes and thus the validity of the results, while the next-generation sequencing (NGS) attain the highest yet unreplicated level of validity results.
ABSTRACT
BACKGROUND: The rehabilitation of canine guidance can be performed with adhesive indirect materials, but can the restoration thickness be reduced without mechanical disadvantages? Thus the goal of this study was to analyze the stress of upper canines which received different thicknesses of ceramic fragments for the rehabilitation of the canine guidance using finite element analysis. METHODS: A superior canine was modeled using a computer aided design software. The dental tissues were individually shaped containing enamel, dentin and periodontal ligament. The following three different ceramic fragment thicknesses were then implemented: 0.3, 0.7 and 1.5 mm. Lithium disilicate was chosen as the ceramic material. The solid geometries were exported to the analysis software. The materials were considered isotropic, homogeneous and linear. The set was submitted to efforts in the incisal third in the palatine face to analyze maximal principal stress, mimicking mandibular lateral movement. The applied load was 100N, and the fixation region was on the medullary bone. RESULTS: For restoration, the thinner the ceramic, the higher the stress concentration was; while for the adhesive surface of teeth, the thicker the ceramic, the higher the stress concentration. CONCLUSIONS: The smaller the ceramic thickness was, the lower stress concentration showed at the adhesive interface, while the stress concentration was higher on the restoration intaglio surface.
