ABSTRACT
We here describe a patient showing topographical disorientation (TD) after infarction of the right medial occipital lobe; the lesion included the parahippocampal gyrus. Clinical and neuropsychological observations demonstrated a specific pattern of impairment in terms of visual and visuospatial (topographical) learning, and memory. He had no landmark agnosia. His defective route finding resulted from impaired allocentric and egocentric spatial representations. Drawing illustrations of both familial and unfamiliar place and orientation tasks in an egocentric coordination context is a useful means of recognizing the influence of egocentric and/or allocentric spatial disturbance. The definition of "allocentric" or "egocentric" is confusing, and requires a standard for differentiating TD types.
Subject(s)
Confusion/physiopathology , Hippocampus/physiopathology , Infarction/physiopathology , Space Perception/physiology , Agnosia/diagnosis , Confusion/diagnosis , Confusion/etiology , Humans , Infarction/diagnosis , Male , Memory/physiology , Memory Disorders/diagnosis , Memory Disorders/physiopathology , Middle Aged , Neuropsychological Tests , Psychomotor Performance/physiologyABSTRACT
A 38-year-old Japanese man with Nasu-Hakola disease (NHD) had repeated pathological fractures and frontal lobe symptoms which developed when he was 18 and 26 years old, respectively. Neuropsychological testing showed memory impairment, and in particular, visuo-spatial memory at the age of 35. Furthermore, single-photon emission computed tomography revealed precuneus hypoperfusion. The patient later suffered prolonged convulsive seizures, which left him in a persistent vegetative state. Genetic testing confirmed a heterozygous mutation in the DAP12 gene (a single-base deletion of 141 G in exon 3) specific to NHD. Precuneus dysfunction might contribute to characteristic memory impairment of NHD.
Subject(s)
Adaptor Proteins, Signal Transducing/genetics , Lipodystrophy/genetics , Membrane Proteins/genetics , Osteochondrodysplasias/genetics , Subacute Sclerosing Panencephalitis/genetics , Adult , Asian People/genetics , Disease Progression , Frameshift Mutation , Humans , Japan , Lipodystrophy/diagnosis , Lipodystrophy/physiopathology , Lipodystrophy/psychology , Magnetic Resonance Imaging , Male , Neuropsychological Tests , Osteochondrodysplasias/diagnosis , Osteochondrodysplasias/physiopathology , Osteochondrodysplasias/psychology , Sequence Deletion , Subacute Sclerosing Panencephalitis/diagnosis , Subacute Sclerosing Panencephalitis/physiopathology , Subacute Sclerosing Panencephalitis/psychology , Tomography, Emission-Computed, Single-PhotonABSTRACT
Historically, schizophrenics' body image problems were regarded as related particularly to delusions and hallucinations. However, during the 1980s, the predominant view of the phenomenology of the disorder broadened to include negative symptoms; deviations in schizophrenics' body image underlie various behaviors or allegations concerning the body and should be refocused. The present study attempted to detect body image deviations in chronic schizophrenia using the Body Image Questionnaire (BIQ), which comprises three hypothetical components (anatomical, functional and other psychological components), and to clarify their related clinical characteristics in symptoms and insight. The BIQ was administered to 93 chronic schizophrenics (diagnosed according to DSM IV; 44 men and 49 women) and 177 normals (78 men and 99 women) adults. The combined data of the three BIQ components in schizophrenic and normal subjects were factor-analyzed separately, and factor scores obtained were compared between schizophrenic and normal groups. The factor scores that differentiated groups were further compared between schizophrenic subgroups, determined by high or low scores for positive symptoms assessed by Scale for the Assessment of Positive Symptoms, negative symptoms by Scale for the Assessment of Negative Symptoms and insight by the Schedule for Assessing Insight. Significant differences between diagnostic groups were found in five of nine factor scores. Dullness in movement, powerlessness, unusually strong gastrointestinal function, lifelessness and fragility proved to be the deviated body images in chronic schizophrenic patients. Powerlessness and lifelessness proved to be related to positive and negative symptoms, and unusually strong gastrointestinal function and fragility to insight.
