1.
Bioorg Med Chem Lett
; 12(4): 629-32, 2002 Feb 25.
Article
in English
| MEDLINE
| ID: mdl-11844687
ABSTRACT
Replacement of the thiol groups in 1, a potent and highly selective Candida albicans GGTase I inhibitor discovered through screening, with an imidazole ring was achieved by using solid phase synthesis. A non-thiol compound, 7, was found as a representative of a new class of potent C. albicans GGTase I inhibitor with high selectivity against human GGTase I.