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1.
Biosens Bioelectron ; 21(6): 957-64, 2005 Dec 15.
Article in English | MEDLINE | ID: mdl-16257665

ABSTRACT

We propose a new strategy for constructing a mediator-type biosensor as a Bio-MicroElectroMechanical Systems (BioMEMS) application. A vinylferrocene plasma-polymerized film (PPF) was deposited directly onto the surface of an electrode under dry conditions. The resulting redox film was extremely thin, adhered well onto a substrate (electrode), and had a highly crosslinked network structure. This technique, capable of polymeric deposition of any kind of monomer, can also serve the purpose of anti-fouling coating, or layer-to-layer interface creation. With a subsequent plasma process, additional polymeric layer of hydrophilic acetonitrile was superimposed onto the existing vinylferrocene-PPF surface to offer crucial features such that the wettability could be adjusted for a better electron transfer, and amino functional groups could be attached to immobilize a large amount of enzyme. Based upon this scheme, the device fabrication could be designed in a manner that the whole procedure was made up of dry wafer-handling processes, which is compatible with mass production. A prototype device was fabricated to have an array of needle-shaped amperometric micro-biosensors. The resultant thin polymer layer carried a large number of the mediator molecules, accomplishing a lower overpotential (+410 mV) and a rapid response time (<5s). Stressing the advantages of the plasma polymerization process together with some additional features accomplished in our device fabrication, we would discuss new possibilities in the field of BioMEMS.


Subject(s)
Biosensing Techniques/instrumentation , Crystallization/methods , Electrochemistry/instrumentation , Ferrous Compounds/chemistry , Hot Temperature , Microelectrodes , Vinyl Compounds/chemistry , Biosensing Techniques/methods , Coated Materials, Biocompatible/chemistry , Cross-Linking Reagents/chemistry , Electrochemistry/methods , Electron Transport , Equipment Design , Equipment Failure Analysis , Gases/chemistry , Miniaturization , Organic Chemicals/chemistry
3.
4.
Evolution ; 25(1): 119-128, 1971 Mar.
Article in English | MEDLINE | ID: mdl-28562944
5.
Evolution ; 25(2): 281-285, 1971 Jun.
Article in English | MEDLINE | ID: mdl-28563106
6.
Evolution ; 21(3): 518-531, 1967 Sep.
Article in English | MEDLINE | ID: mdl-28563691
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