ABSTRACT
The authors subjected 66 patients suffering from COBP with chronic respiratory insufficiency (22 with EGA values within standard limits, 44 with irregular PO2 and PCO2 values) to an electroencephalography with BEAM (brain electrical activity mapping). In the absence of clinically noticeable symptoms or neurologic signs of central type, more than 65% of the patients showed an increase of slow activities together with a reduction of the alpha activity presumably imputable only to the respiratory pathology.
Subject(s)
Brain/physiopathology , Electroencephalography/instrumentation , Lung Diseases, Obstructive/physiopathology , Signal Processing, Computer-Assisted/instrumentation , Adult , Aged , Alpha Rhythm , Brain Damage, Chronic/physiopathology , Brain Damage, Chronic/rehabilitation , Brain Mapping/instrumentation , Carbon Dioxide/blood , Female , Humans , Hypoxia, Brain/physiopathology , Hypoxia, Brain/rehabilitation , Lung Diseases, Obstructive/rehabilitation , Male , Middle Aged , Oxygen/blood , Theta RhythmABSTRACT
This work focuses on the neurophysiological features in a patient with action myoclonus and mental deterioration following methylbromide intoxication. The patient is a 28-year-old man, without respiratory distress or exposure to other toxics. Myoclonus improved with polytherapy (clonazepam, 5-HT, carbidopa, GABA). The neurophysiological and neuropsychological evidence in this patient suggests a possible double site of action of methylbromide at cortical and subcortical levels.
Subject(s)
Hydrocarbons, Brominated/poisoning , Myoclonus/chemically induced , Substance-Related Disorders/diagnosis , Adult , Carbidopa/administration & dosage , Clonazepam/administration & dosage , Drug Therapy, Combination , Electroencephalography/drug effects , Epilepsies, Myoclonic/chemically induced , Epilepsies, Myoclonic/diagnosis , Epilepsies, Myoclonic/psychology , Epilepsy, Tonic-Clonic/chemically induced , Epilepsy, Tonic-Clonic/diagnosis , Epilepsy, Tonic-Clonic/psychology , Evoked Potentials/drug effects , Humans , Male , Myoclonus/diagnosis , Myoclonus/psychology , Reaction Time/drug effects , Substance-Related Disorders/psychologyABSTRACT
Cerebral mapping of the spontaneous electroencephalographic activity was performed in 31 subjects suffering from migraine with aura and the results were compared with those of a matched control group. All the patients were examined during the interictal period. While traditional visual interpretation of EEG records was negative in all but five cases (16.1%) spectral analysis showed an asymmetry in alpha total power over the posterior regions in 13 cases (41.9%) and an asymmetry in alpha band peak frequency in 17 (54.8%). By means of cerebral mapping and statistical significance probability mapping we were able to demonstrate a significant increase in alpha total power in 13 cases (41.9%) and a regional increase in delta and theta total power in 20 cases (64.5%). In comparison with the control group, the migraine patients showed a widespread increase in slow activity (theta and delta) mostly over the temporal regions.
