[Geriatrics or geriatricization of medicine : Quo vadis geriatrics?] / Geriatrie oder Geriatrisierung der Medizin : Quo vadis Geriatrie?

This article examines the question whether and how geriatrics will change in the future and whether in view of the demographic changes the trend will go more in the direction of a further expansion of geriatrics or more towards a geriatricization of individual specialist medical fields. The different development of geriatrics in the individual Federal States can only be understood historically and is absolutely problematic against the background of the new hospital remuneration system. Geriatrics is a typical cross-sectional faculty and still has demarcation problems with other faculties but has also not yet clearly defined the core competence. This certainly includes the increasing acquisition of decentralized joint treatment concepts and geriatric counselling services in the future, in addition to the classical assessment instruments. Keywords in association with this are: traumatology and othopedics of the elderly, geriatric neurology and geriatric oncology. Interdisciplinary geriatric expertise is increasingly being requested. Outpatient structures have so far not been prioritized in geriatrics. An independent research is under construction and it is gratifying that academic interest in geriatrics seems to be increasing and new professorial chairs have been established. It is not possible to imagine our hospital without geriatrics; however, there is still a certain imbalance between the clearly increased number of geriatric hospital beds, the representation of geriatrics in large hospitals (e.g. specialized and maximum care hospitals and university clinics), the secure establishment in further education regulations and the lack of a uniform nationwide concept of geriatrics.

Mini dental assessment: a simple screening test for non-dental staff.

OBJECTIVE: The objective of this study was to develop a simple tool for the assessment of possible dental treatment needs (DTN) for non-dental professionals (Mini Dental Assessment, MDA). To keep the assessment universal, we aimed to base it on the patient's history and a simple chewing efficiency test (CET) as the dental status is a known determinant for chewing efficiency. MATERIALS & METHODS: The assessment was developed using data from 169 patients from two sites (University Hospital Giessen, St. Bonifatius Hospital Lingen, both Germany). In all patients, a dental examination was performed, the denture status was evaluated (based on the California Dental Association criteria; CDA criteria), and the DTN was determined. In addition, the time since the patient's last visit to a dentist (TLVD) and denture age (DA) were assessed. Furthermore, a CET was carried out and the comminution score was determined (CETS). RESULTS: In total, 108 patients required dental treatment. The mean value (±SD) was 2.9 ± 0.9 score points for the DTN, 2.5 ± 3.8 years for the TLVD, and 10.8 ± 8.9 years for the DA. There was a significant correlation (Spearman, P < .05) between the DTN and degree of comminution (3.4 ± 1.8). Based on the results of the statistical analysis, the intended assessment tool was developed using the variables CETS, TLVD, and DA weighed by their respective regression coefficients (10:3:1). Subsequently, the resulting MDA score (51.32 ± 28.14) was calculated. A sensitivity/specificity analysis was conducted and a receiver operating characteristic curve was calculated (SPSS 17.0, area under curve 0.805; 95 % CI 0.738-0.873). CONCLUSION: It can be concluded that the dental status of elderly patients is reflected in the outcome of the MDA. However, ongoing validation is needed. TRIAL REGISTRATION: DRKS00003219.

[Demographic change: Changes in society and medicine and developmental trends in geriatrics]. / Demografischer Wandel : Veränderungen in Gesellschaft und Medizin und Entwicklungstendenzen in der Geriatrie.

BACKGROUND: Increasing life expectancy means growing numbers of elderly survive the critical age for cardiac and vascular diseases only to later experience cancer and dementia. OBJECTIVES: Of the types of cancer affecting men, prostate cancer continues to be diagnosed early by prostate-specific antigen (PSA) screening. The clinical relevance and quality of life of those affected must be critically judged. Depending on life expectancy, active surveillance (AS) and watchful waiting (WW) will be increasingly used in geriatric patients. Risk stratification as guided by CGA facilitates the therapeutic decisions of urologists and spares metastatic castration-resistant prostate cancer patients from unnecessary and adverse overtreatment. By 2030, approximately 1.8 million people will have dementia. CONCLUSIONS: Thus, in the future, the health care system will have to treat an aging population, which will require the creation of increasing numbers of geriatric hospital departments and cooperative models between geriatrics and other specialties. The future training of medical students and continuing medical education must also be further developed to include aspects on aging. Only in this manner will it be possible to effectively confront the challenges associated with demographic change in the specialty of geriatrics.

[Vitamin B12 deficiency in the elderly]. / Vitamin-B12-Mangel im Alter.

The prevalence of vitamin B12 deficiency increases with age. Patients with dementia and spouses of patients with dementia are at special risk for the development of vitamin B12 deficiency. In a normal diet this vitamin is present only in animal source foods; therefore, vegans frequently develop vitamin B12 deficiency if not using supplements or foods fortified with cobalamin. Apart from dementia, most of these manifestations are completely reversible under correct therapy; therefore it is crucial to identify and to treat even atypical presentations of vitamin B12 deficiency as early as possible. This article deals with the physiology and pathophysiology of vitamin B12 metabolism. A practice-oriented algorithm which also considers health economic aspects for a rational laboratory diagnosis of vitamin B12 deficiency is presented. In cases with severe neurological symptoms, therapy should be parenteral, especially initially. For parenteral treatment, hydroxocobalamin is the drug of choice.

[Acetylsalicylic acid non-responders after ischemic insult in geriatric patients]. / Acetylsalicylsäure-Nonresponder nach ischämischem Insult bei geriatrischen Patienten.

BACKGROUND: The cardiovascular and cerebral ischemic risk is defined as the risk of suffering a thromboembolic event. The common secondary prophylaxis is still the use of acetylsalicylic acid (ASA). The usual daily dose is 100 mg. Efficacy concerning platelet aggregation is not routinely checked. MATERIAL AND METHODS: In this study, patients taking 100 mg aspirin daily (orally) were examined after admittance to the stroke unit due to a stroke or stroke recurrence. Platelet aggregation was performed using a Platelet Function Analyser (PFA 100). RESULTS: A total of 71 patients were examined, 53(73%) had experienced a primary ischemic insult, and 18(25.4%) stroke recurrence. Patients with prolonged closure time in the collagen/epinephrine cell (normal range 85-165 s) were classified as responders to ASA, while 14 (19.7%) were classified as non-responders. CONCLUSION: It remains open whether the secondary prophylaxis or a more effective inhibition of platelet aggregation results in the improved protection against a future event.

[Geriatric medicine. Current status and perspectives for the future]. / Geriatrie. Aktuelle Bedeutung und Zukunftsperspektiven.

Geriatric medicine is one of the most rapidly growing medical subspecialties as a response to demographic changes seen in all western societies. One of the main problems of all aging populations is the increase in incidence and severity of comorbidities. Three epidemiological types of (co)morbidities can be identified: (1) Cardiac and vascular diseases including risk factors like diabetes mellitus, (2) malignancies of the elderly and (3) cognitive impairments defined as dementia. These epidemiologic-medical classes need different strategies. The first morbidity type is addressed by preventive medicine and modern therapy with great successes in recent years. In contrast, malignant diseases are continuously increasing in the elderly cohort, but a variety of new therapeutic measure shave turned some previously fatal disorders into chronic ones. In contrast, neither preventive nor therapeutic measures are available for dementia. Our response is better care and support, which demands specialized human resources that are becoming scarce. Better training of more individuals to care for elderly is a great challenge for our society.

[Myelopoiesis and bone marrow function in elderly tumor patients]. / Myelopoese und Knochenmarkfunktion des alten Tumorpatienten.

According to a model described by Balducci, the human myelopoietic stem cell reserve shows a shift from the reproductive to the proliferative pool corresponding to higher immunological demands resulting from the breakdown of infection defences. Every "hematopoietic stress," i.e., sepsis and/or cytoreductive chemotherapy, leads to a reduction of myelopoietic stem cells in the elderly in contrast to an increase in younger individuals. These changes are relevant starting at the age of 70 years and show a reduced compensation capacity in the aged organism. In addition, the function of the effector cells, i.e., the granulocytes and especially their phagocytic capacity, as well as the balance between stimulating and inhibiting cytokines are compromised. A significant influence on leukopenia and febrile septicemia has been shown for several comorbidities, especially chronic inflammation. The prophylactic use of myelopoietic growth factors is, therefore, recommended for the elderly when there is an expected risk for hematotoxicity grade III or IV. However, prognostic tests to predict the individual risk of hematotoxicity and septicemia are lacking.

[Diagnostic and treatment goals in elderly patients]. / Diagnostik- und Therapieziele beim alten Patienten.

Improved quality of life and greater independence are becoming increasingly important as treatment goals in elderly patients, while merely extending life expectancy is only rarely the primary treatment goal. In elderly patients in particular, the patient's wishes are extremely important when deciding on the treatment goals. If patients are no longer able to express their wishes, the treating physician must establish what their presumed wishes are. Relatives and carers are particularly important in determining a patient's presumed wishes. A standardized geriatric assessment and interventions conducted on the basis of this assessment can give patients greater independence in everyday activities (e.g., walking, personal hygiene, eating) and can avoid them having to go into a nursing home or at least delay this move. In addition, the patient's prognosis is improved, which is manifested inter alia in a longer life-span. A basic geriatric assessment should therefore be conducted in all elderly patients. Standardized testing methods are used to examine the following areas: everyday activities, mobility/risk of falling, and cognition. Patients with the relevant risk combinations should also be screened for malnutrition. Comorbidities are a decisive factor influencing the prognosis in tumor patients. The comorbidities should be recorded using a structured method, e.g., the Charlson Comorbidity Index, and taken into account when deciding on treatment.

[Chances and risks of prevention in elderly people for the three major cancers: breast-, prostate- and colorectal cancers]. / Chancen und Risiken der Vorsorge bei älteren Menschen bezogen auf die grossen Drei: Mammakarzinom, Prostatakarzinom und kolorektale Karzinome.

The big three, breast cancer (BC), prostate cancer (PC) and colorectal carcinoma are the most frequent malignancies world wide and also typical tumors of advanced age. Therefore the question to screen and how to screen for these tumors in the elderly is the main question for reduction of the total cancer burden and mortality in all western countries. BREAST CANCER (BC): The age related risk of BC increases from 1 : 2,500 at age 30+ to > 1 : 10 at age 80. Nevertheless, most of the national BC-Screening-Programs stop at age 60 or earlier. Therefore the majority of all advanced i. e. T (4) stages of BC are found in women age > 60. Frequently it is suggested that age related comorbidity should eliminate the benefit of treatment. Recently two longitudinal studies have clearly shown that correct standard treatment is as effective in elderly as in younger individuals. Mammography (MG) has been shown to reduce mortality of BC significantly with best results for specificity and sensitivity at age 70+. PROSTATE CANCER (PC): The screening situation of PC is quite different to BC, because risk profiles are poorly defined and the benefit of radical prostatectomy is not clearly demonstrated in the early non symptomatic stages of PC. At the other side watchful waiting leads to an elevated frequency of incontinence and enuresis as well. Two studies are now under progress and may possibly change the situation; but the final results are expected 2005-2008 at the earliest. Therefore an assisted individual decision making is the only recommendation at this time. COLORECTAL CANCER (CC): Risk groups are clearly defined. Risk of the elderly (> 60) is the average risk. The incidence increases from < 50/10 (5) to more than 500 at age 75+(male) and 500 (female). When to start and when to stop screening? Experts give the advice to begin at age 50 and to end at age 80; but this is not really evidence based. There are several unanswered questions and open problems: we are not exactly informed about complication rates of colonoscopy during the screening programs. There is a lack of data according accuracy of barium enema, virtual colonoscopy and genetic stool test in comparison to colonoscopy in combination with fecal occult blood test (FOBT). And adherence to screening is not well documented among informed patients. However, effectiveness of CC-screening (FOBT alone or in combination with colonoscopy) has been documented in three high randomised trials which have shown a disease specific mortality reduction of 15-33 % over a period of 8-13 years. But it must be clear that the economic resources must be mobilised individually or by insurance: offering the testing of only FOBT for ten years to one thousand persons can save one life.

["Memory-clinics" in German-speaking countries]. / Gedächtnissprechstunden: "Memory-Kliniken" im deutschsprachigen Raum.

This article gives an evaluation of the organization, diagnostics and offers of therapy from 41 memory-clinics conducted in German-speaking countries and shows that there is no uniform standard for the care of those suffering from dementia. As a result there are problems with quality assurance and financing. The survey shows that Switzerland has the most extensive as well as intensive care program which is also appropriately funded. It is therefore necessary to provide guidelines for defining a uniform quality standard while taking into account the reasons of the various institutes for implementing such departments. It is also essential that these guidelines do justice to the patients and their relatives.