ABSTRACT
Diabetes mellitus (DM) is still one of the most common endocrine diseases despite all available technologies in modern medicine. In recent years, it was shown that severity and duration of DM are closely associated with vascular wall lesions (the called micro-and macroangiopathy). One of severe clinical signs is damage to lower limb arteries followed by trophic and purulent-necrotic lesions of soft tissues (diabetic foot syndrome) and risk of amputation. The authors review the possibilities of endovascular treatment of critical limb ischemia in patients with diabetes mellitus. The features of endovascular interventions depending on clinical and morphological peculiarities of vascular lesions are discussed. The authors compared the results of open and endovascular treatment of lower limb ischemia and determined further prospects for improving the treatment of these patients.
Subject(s)
Diabetes Mellitus , Endovascular Procedures , Amputation, Surgical , Chronic Limb-Threatening Ischemia , Diabetes Mellitus/diagnosis , Endovascular Procedures/adverse effects , Humans , Ischemia/diagnosis , Ischemia/etiology , Ischemia/surgery , Limb Salvage , Retrospective Studies , Risk Factors , Treatment OutcomeABSTRACT
Type 2 diabetes mellitus was modeled in newborn albino rat pups. Metabolism and contractile activity of isolated heart under conditions of hypoxia were studied on adult rats. Contractile activity of the myocardium in animals with type 2 diabetes mellitus and abdominal obesity decreased during hypoxia. It was manifested in a decrease in systolic and developed pressure and disturbances in diastolic relaxation of the myocardium. Damage to cell membranes and increased secretion of aspartate transaminase into the coronary circulation were observed under conditions of energy deficit and activation of the anaerobic pathway of energy production. These changes became more pronounced with increasing the period of hypoxic exposure.
