PERSONIFICATION OF ANTIHYPERTENSIVE THERAPY IN ISCHEMIC CEREBRAL STROKE.

The purpose of the study is to optimize monitoring and personalize antihypertensive therapy in patients with severe ischemic cerebral stroke (ICS). We examined 37 patients with ICS, average age 74,1±1,3 years, who received treatment in intensive care wards of the stroke department with general neurology beds of the Municipal Non-Profit Enterprise "City Hospital № 9" of the Zaporizhzhia City Council. There were 16 men (43,2%), average age 71,9±2,1 years; women - 21 (56,8%), average age 75,8±1.6 years. Personification of antihypertensive therapy for severe ICS was carried out based on the etiology of hypertensive hemodynamic disorders: hyperkinetic type of arterial hypertension (Cardiac index ≥ 3,80 L×min-1×m-2) or hypokinetic type of arterial hypertension (Cardiac index ≤ 2,98 L×min-1×m-2). In patients with severe ICS and hyperkinetic type of arterial hypertension, initial hemodynamic parameters were characterized by Mean arterial pressure (MAP) of 111,4 ± 1,4 mm Hg; Heart rate (HR) of 107,2±1,6 min; Cardiac index (CI) 6,74±0,27 L×min-1×m-2; the Total peripheral vascular resistance (TPVR) is 674±36 dyn×sec-1×cm-5. For the purpose of antihypertensive correction of the hyperkinetic type of arterial hypertension (CI ≥ 3,80 L×min-1×m-2), a solution of Magnesium Sulfate was used intravenously at a dose of 2500-5000 mg×day-1 in combination with Bisoprolol 5-10 mg×day-1 orally. This made it possible to stabilize hemodynamic parameters by the end of intensive therapy within the limits of eukinetic values: MAP 95,2±1,5 mm Hg (p<0,05); HR 81,9±1,5 min (p<0,05); CI 3,60±0,15 L×min-1×m-2 (p<0,05); TPVR is 1079±58 dyn×sec-1×cm-5 (p<0,05). In patients with severe ICS and hypokinetic type of arterial hypertension, initial hemodynamic parameters were characterized by MAP of 117,7±2,8 mm Hg; HR of 76,7±1,5 min; CI 2,74±0,18 L×min-1×m-2; TPVR is 1754±123 dyn×sec-1×cm-5. For the purpose of antihypertensive correction of the hypokinetic type of arterial hypertension (CI≤2,98 L×min-1×m-2), a solution of Ebrantil was used intravenously as a bolus of 1,25-2,5 mg with a further infusion of 5-40 mg×hour-1. This made it possible to stabilize hemodynamic parameters by the end of intensive therapy within the limits of eukinetic values: MAP 92,7 ± 1,7 mm Hg (p<0,05); HR 81,4 ± 0,9 min (p<0,05); CI 3,65±0,16 L×min-1×m-2 (p<0,05); TPVR is 1036±46 dyn×sec-1×cm-5 (p<0,05).

ANALYSIS OF QUANTAL PARAMETERS OF GABA RELEASE DURING SHORT-TERM DEPRESSION AND FACILITATION OF SYNAPTIC TRANSMISSION.

Changes in amplitudes of evoked inhibitory postsynaptic currents (eIPSCs) from rat cultured hippocampal neurons were studied using whole-cell patch-clamp technique in postsynaptic neuron and local extracellular electrical paired pulse stimulation of single presynaptic axon. Paired pulse depression (PPD) and paired pulse facilitation (PPF) were observed in studied 43 neurons. According to coefficient of variance (CV) analysis was found that CV of second respond was significantly larger than CV first by 57 % (n 26) during depression and significanty smaller by 27 % (n = 17) during facilitation. Thus, only presynaptic mechanism underlies short-term depression and facilitation. We also estimated quantal parameters assuming that transmitter release is reasonably described by a binomial distribution. We found that under our experimental conditions there were no significant changes in GABA release probability during PPD and PPF. The values of mean quantal content and mean number of sites of transmitter release were the same for first stimulus in pair and were equal 9.7 in depression and 5 in facilitation of synaptic transmission. The values both of them for second stimulus were significant decreased by 28 and 26% during PPD and were significant increased by 14 and 11% during PPF, respectively. Thus, there is significant difference in quantal parameters characterizing GABA release during short-term depression and facilitation of synaptic transmission.

Fast dynamic holographic recording based on conductive ionic metal-alkanoate liquid crystals and smectic glasses.

Recordings of dynamic holograms with microsecond relaxation times under the action of nanosecond laser pulses are obtained in composites on the base of a novel class of liquid crystals (LCs) in ionic metal-alkanoates. Holographic parameters and relaxation characteristics are measured for doped lyotropic ionic LC, for sandwichlike cells (consisting of a dye layer and a layer of the lyotropic ionic LC), and for colored ionic smectic glasses. The structure of the materials is investigated by use of the small-angle x-ray technique. The mechanism of resonance nonlinearity in photosensitive centers and mechanisms of the grating erasure connected with a charge transport in the ionic conductive LC matrix are discussed.

[Structural and functional stage of the myocardium in different forms of ischemic heart disease].

152 patients with ischemic heart disease aged from 46 to 60 years have been observed. Among these patients, 69 were with stable stenocardia, 32--with unstable stenocardia and 53--in stage related to acute heart attack. Normal geometry of the heart was found in 33% of patients with stable stenocardia, excentric hypertrophy was found in 30% of patients with stable stenocardia. Excentric hypertrophy prevailed in patients with unstable stenocardia and myocardial infarction. Systolic disfunction of the myocardium was found in 72% of patients with stable stenocardia, in 41% of patients with unstable stenocardia and in 43% of patients with myocardial infarction. Diastolic dysfunction of the myocardium in terms of rigide and restrictive types was found oftener in patients with myocardial infarction.

[The ways of the efficacy raising in surgical treatment of patients with colonic cancer]. / Shliakhy pidvyshchennia efektyvnosti khirurhichnoho likuvannia khvorykh na rak obodovoï kyshky.

The indications extension for the radical surgical intervention conduction in elderly and senile patients and with locally spreading colonic cancer had promoted the result of their treatment improvement.