[The functional-morphological status of the stomach in rheumatism patients]. / Funktsional'no-morfolohichnyi stan shlunka u khvorykh na revmatyzm.

151 rheumatics aged between 16 and 70 were examined. 110 of them had active rheumatism, in 41 inactive form of the disease was diagnosed. Various gastric changes found in 90.5% of patients were related both to rheumatism and adverse effects of antirheumatic treatment as well as to concomitant diseases of stomach and duodenum. Achlorhydria resistant to pentagastrin was rather in patients with rheumatism. This may be explained by predominant lesions of main cells while parietal cells remain quite intact.

[The morphofunctional changes in the periodontal tissues in cardiovascular pathology]. / Morfofunktsional'nye izmeneniia v tkaniakh parodonta pri serdechno-sosudistoi patologii.

Five rheoparodontographic curve types were distinguished, characterizing the severity of periodontal condition and the underlying disease. Morphologic examinations have revealed specific features of involvement of the periodontal regional hemomicrocirculation bed, leading to disorders in energy metabolism and development of circulatory and tissue hypoxia. The detected changes result in rapid progress of the pathologic process in periodontal tissues and should be paid special attention to when planning the treatment strategy.

[Non-clostridial anaerobes in the etiopathogenesis of perivesical cholangiogenic abscesses of the liver]. / Neklostridial'nye anaéroby v étiopatogeneze perivezikal'nykh kolangiogennykh abstsessov pecheni.

The authors had under observation 318 patients who were subjected to operation and suffered from various inflammatory diseases of the bile tract; perivesical and cholangiogenic abscesses of the liver were found in 33 of them. Bacteriological tests of the contents of the abscesses demonstrated most frequently the presence of Bacteroides fragilis as a monoculture in cholangiogenic abscesses and associations of anaerobic and aerobic bacteria in perivesical abscesses. Early operation with obligatory consideration for the anaerobic component of the microflora is recommended.

[Ultrastructural analysis of the effects of the aphakia gene in mice embryos]. / Ul'trastrukturnyi analiz éffektov gena aphakia u zarodyshei myshi.

A light and electron microscope studies of the lenses in ak/ak and +/+ mice at different stages of embryogenesis have shown that the earliest effect of the mutant gene ak at the subcellular level was the destructive change of the cell organelles in the early invaginating placode. As a result, the formation of the basal membrane of the lens placode cells and, later on, the lens capsule development were affected. The destructive changes of the cells were accompanied by a weakening of intercellular contacts and the transport of the degenerating cells into the lens vesicle cavity.

[Effects of a single dose of the mutant gene CatFr in mouse ontogeny]. / Izuchenie éffektov odinarnoi dozy mutantnogo gena CatFr v ontogeneze myshi.

A study of the lenses of CatFr/+ and +/+ mice at different stages of embryonic and postembryonic development by means of electron and light microscopy has shown that the effect of CatFr gene single dose is characterized by a more rapid denucleation of lens fibers, as compared with the normal development. Defects of the nuclear envelope structure, similar with those described earlier for homozygotes, were observed in the developing lenses of heterozygotes. In CatFr/+ mice, unlike in homozygotes, the nuclei of primary lens fibers are not practically affected but those of secondary fibers are destroyed, thus leading to the lysis of these fibers and the development of cataract. The expression of CatFr gene in heterozygotes is due to additive interaction of its effects and "denucleation" process.

[Ultrastructural analysis of the effects of dominant cataract-Fr gene in mouse embryos]. / Ul'trastrukturnyi analiz effektov gena dominant cataract-Fr u embrionov myshi

An electron microscope study of lenses in 11--15 and 17 days old embryos of mice homozygous by dominant cataract-Fr (CatFr) gene has shown that ultrastructural changes in the nuclear envelope are the earliest expression of the mutant gene. The primary lens fibers of 12 days old embryos CatFr/CatFr, unlike those of the normal ones, are characterized by the decrease in the number of nuclear pores, evagination of the outer nuclear membrane, marked and unequal extension of perinuclear space which connects itself with the endoplasmic reticulum cisternae. In 14 days old embryos breaks in the outer nuclear membrane and evaginations in the inner one, fusion of nuclear membranes and breaks of the nuclear envelope are observed and resulted in the release of the nuclear contents with the nucleolus in the cytoplasm. Similar ultrastructural changes are characteristic also of the nuclei of secondary lens fibers at a comparable stage of differentiation. The destructive changes of nuclei are accompanied by the degeneration and autophagocytosis of cellular organelles and matrix.