ABSTRACT
Evaluation of lipid peroxidation in patients with occupational allergic dermatoses revealed activation of free radical oxidation. Serum levels of diene conjugates and end products of free radical lipid peroxidation appeared to be informative parameters for assessing influences on body system and for estimating the disease severity and the individual protective means efficiency.
Subject(s)
Chemical Industry , Dermatitis, Occupational/metabolism , Lipid Peroxidation/physiology , Occupational Exposure/adverse effects , Adult , Antioxidants/metabolism , Antioxidants/poisoning , Dermatitis, Occupational/blood , Dermatitis, Occupational/classification , Female , Free Radical Scavengers/metabolism , Free Radical Scavengers/poisoning , Humans , Male , Middle Aged , Severity of Illness Index , Time Factors , WorkforceABSTRACT
Evaluation of genes polymorphic system of xenobiotics biotransformation in patients with occupational allergodermatoses showed significantly higher percentage of incidence of polymorphic variants of genes CYP 1A1 *2C and EPHX1 AND-415G compared with population control. A combination of 3 or more adverse hetero--and homozygous gene alleles CYP 1A1, CYP3A4, EPHX1 and deletions of genes GSTM1 and GSTT1, is characterized by earlier (with the experience of work in harmful conditions up to 5 years) development, severe and unfavorable prognosis of occupational pathology of the skin.
Subject(s)
Biotransformation/genetics , Dermatitis, Occupational , Polymorphism, Genetic , Xenobiotics , Adult , Asthma, Occupational/chemically induced , Asthma, Occupational/genetics , Comorbidity , Dermatitis, Allergic Contact/genetics , Dermatitis, Occupational/etiology , Dermatitis, Occupational/genetics , Eczema/chemically induced , Eczema/genetics , Female , Gene-Environment Interaction , Genetic Predisposition to Disease , Genome-Wide Association Study , Humans , Male , Prognosis , Time Factors , Xenobiotics/adverse effects , Xenobiotics/pharmacokineticsABSTRACT
DNA diagnostic techniques aimed at elaborating informative criteria for assessment of the risk for occupational, occupationally induced diseases are extensively used to study the molecular mechanisms involved in the development of occupational diseases in labor medicine. Patients with different forms of occupational bronchopulmonary diseases have been found to have matrix metalloproteinase-1 (MMP-1) gene mutations. In some individuals, a combination of polymorphic variants of MMP-1 and alpha1-proteinase inhibitor genes is characterized by the presence of clinical complications and the concurrence of bronchopulmonary and skin diseases. GSTM1 gene mutation is noted for the earlier onset (up to 5 years), severity, and poor prognosis of allergic dermatoses.
Subject(s)
Glutathione Transferase/genetics , Matrix Metalloproteinase 1/genetics , Occupational Diseases/genetics , Polymorphism, Single Nucleotide , alpha 1-Antitrypsin/genetics , Dermatitis, Allergic Contact/complications , Dermatitis, Allergic Contact/epidemiology , Dermatitis, Allergic Contact/genetics , Dermatitis, Occupational/complications , Dermatitis, Occupational/epidemiology , Dermatitis, Occupational/genetics , Genetic Association Studies , Genetic Predisposition to Disease , Humans , Male , Middle Aged , Occupational Diseases/epidemiology , Predictive Value of Tests , Respiratory Tract Diseases/complications , Respiratory Tract Diseases/epidemiology , Respiratory Tract Diseases/genetics , Severity of Illness Index , Time FactorsABSTRACT
Studying genetic polymorphism of xenogiotics biotransformation system genes in patients with occupational allergic dermatoses, the authors revealed reliably higher percentage of polymorphous variants of CYP 1A1 *2C and EPHX1 A-415G genes, if compared with reference population. Combination of 3 polymorphous variants of xenobiotics biotransformation system genes (CYP 1A1, CYP3A4, EPHX1, GSTM1 and GSTT1) is characterized by earlier development, severe course and unfavorable prognosis of occupational skin condition.
