ABSTRACT
The occurrence rate of HLA class I and class II alleles was established in 24 patients suffering from dermatological disorders associated with the Helicobacter pylori infection. The increased frequency of HLA-C*0602, 4 was found to be 0.1875 compared to 0.0733 in the control group (odds ratio: 2.913; two-sided P value: P = 0.0251). Our data suggest that the HLA-Cw6 molecule play a role in the susceptibility to the Helicobacter pylori infection.
Subject(s)
Genetic Predisposition to Disease/genetics , HLA-C Antigens/genetics , Helicobacter Infections/immunology , Helicobacter pylori , Skin Diseases, Bacterial/immunology , Alleles , DNA/blood , Gastritis/microbiology , Gene Frequency , HLA-A Antigens/genetics , HLA-B Antigens/genetics , Helicobacter Infections/genetics , Humans , Odds Ratio , Polymerase Chain Reaction , Reference Values , Skin Diseases, Bacterial/geneticsABSTRACT
By investigating a group of 39 unrelated adults suffering from vitiligo it was found that alleles HLA-DRB1*0701, -DQB1*0201, and -DPB1*1601 differed in their frequencies in comparison to those observed in the healthy population. The allele HLA-DRB1*0701 was found in 26.5% of patients compared to 14.2% in the healthy group (p < 0,01, RR = 2.17). The allele HLA-DQB1*0201 was present in 33.8% of patients compared to 21.2% (p < 0,025, RR = 1.89). The allele HLA-DPB1*1601 was found in 6.41% of patients compared to 2.05% in the healthy group (p < 0.05, RR = 3.3). No other significant deviations in the frequencies of investigated alleles were observed.
Subject(s)
HLA-DP Antigens/genetics , HLA-DQ Antigens/genetics , HLA-DR Antigens/genetics , Vitiligo/genetics , Adult , Alleles , Chi-Square Distribution , Female , Gene Frequency , Genetic Markers/physiology , HLA-DP beta-Chains , HLA-DQ beta-Chains , HLA-DRB1 Chains , Humans , Male , Polymerase Chain Reaction , Reference Values , Sensitivity and Specificity , SlovakiaABSTRACT
The authors describe an infectious disease, rarely occurring in the Slovak Republic-superficial trichophytia caused by Trichophyton tonsurans var. sulphureum-in a 37-year-old male patient with psoriasis. Untreated oval to circular foci 4-10 x 5-12 cm in size were localised on the forearms and knee, gradually developing black dots remaining after broken hair (parasitismus endothrix). After a failure in local and overall therapy by imidazole antibiotics, the peroral therapy by terbinafine (Lamisil) was successful. (Fig. 2, Ref. 19.)
Subject(s)
Tinea Capitis , Adult , Antifungal Agents/therapeutic use , Humans , Male , Naphthalenes/therapeutic use , Psoriasis/complications , Terbinafine , Tinea Capitis/complications , Tinea Capitis/drug therapy , Tinea Capitis/pathologyABSTRACT
The authors describe a case of a 31 year old woman who suffered from sclerodermia circumscripta on her right leg. The diagnosis was histopathologically verified. Capillaroscopy and respiratory obstruction were positive. A new lesion appeared on the right arm thus imitating morphea. However, by means of mycological examinations Microsporum gypseum infection was recognized. (Fig. 3, Ref. 13.).
Subject(s)
Dermatomycoses/diagnosis , Microsporum , Scleroderma, Localized/diagnosis , Adult , Diagnostic Errors , Female , HumansABSTRACT
By investigating a group of 67 unrelated adult persons suffering from vitiligo it was found that antigens HLA-A2 and HLA-Dw7 differed in their frequencies in comparison to those observed in the healthy population. The antigen HLA-A2 was found in 76.12% of patients compared to 43.95% in the control group (chi 2 = 25.61, P < 0.005, RR = 4.07). The antigen HLA-Dw7 was present in 56.71% of patients compared to 15.8% in the healthy population (chi 2 = 26.55, P < 0.0001, RR = 6.98). No other significant deviations in the frequencies of investigated antigens were observed.
Subject(s)
HLA-A2 Antigen/analysis , HLA-D Antigens/analysis , Vitiligo/immunology , Adolescent , Adult , Aged , Child , Female , Humans , Male , Middle Aged , SlovakiaABSTRACT
The work gives a review of therapeutic methods of vitiligo. PUVA therapy, application of cortisonoids, khellin (including UVA), phenylalanine (including UVA), melagenina, and laser therapy represent non-surgical methods. Surgical methods include application of fluorouracil following dermabrasion, of autologous epidermal grafting transplantation of in vitro cultured epidermis, in vitro cultured melanocytes and micropigmentation by pigment. Auxiliary methods are represented by administration of carotene, using sunscreens and if necessary cosmetic treatment. Entire depigmentation is done in accordance with the extent of vitiligo, unsuccessful repigmentation and the age of the patient. The conclusion points out psychosocial aspects and the necessity of mutual cooperation of both, physician and patient. (Ref. 53.)
