ABSTRACT
BACKGROUND: Apraclonidine 1.0% has been shown to reverse the potential intraocular pressure (IOP) increase after pupil dilation IOP increases in patients with chronic open-angle glaucoma. However, it is only approved for preventing IOP spikes after laser surgery. The purpose of this study is to determine the effectiveness of 0.5% apraclonidine in reversing IOP increases after pupillary dilation in patients with chronic open-angle glaucoma. METHODS: Twenty-two patients with chronic open-angle glaucoma were found to have an increase in post-dilation IOP of at least 4 mmHg from pre-dilated levels (baseline) in both eyes. IOP was measured 1 hour after dilation, after which two drops of 0.5% apraclonidine were instilled in one eye and the IOP was remeasured 15 minutes later in both eyes. Instillation of 0.5% apraclonidine in one eye was continued every 15 minutes and IOP was measured 15 minutes after each instillation, until the pressure returned to baseline levels. RESULTS: The IOP of the initially treated eye of all 22 patients returned to within levels clinically insignificant from baseline IOP within 90 minutes. By comparison, the IOP of the control group (untreated eye) remained elevated. Once the initial treatment eye returned to baseline levels, the control group was then treated with 0.5% apraclonidine, resulting in a lowering effect of the IOP in similar fashion to the initial treated group. CONCLUSIONS: Apraclonidine 0.5% appears to be effective in reduction of post-dilated IOP increases in patients with chronic open-angle glaucoma.
Subject(s)
Adrenergic alpha-Agonists/therapeutic use , Clonidine/analogs & derivatives , Glaucoma, Open-Angle/drug therapy , Intraocular Pressure/drug effects , Mydriatics/administration & dosage , Pupil/drug effects , Adrenergic alpha-Agonists/administration & dosage , Aged , Aged, 80 and over , Chronic Disease , Clonidine/administration & dosage , Clonidine/therapeutic use , Double-Blind Method , Fundus Oculi , Glaucoma, Open-Angle/diagnosis , Glaucoma, Open-Angle/physiopathology , Humans , Male , Middle Aged , Ophthalmic Solutions/administration & dosage , Ophthalmic Solutions/therapeutic use , Phenylephrine/administration & dosage , Tropicamide/administration & dosageSubject(s)
Chromosomes, Human, Pair 8 , Eye Abnormalities/genetics , Iris/abnormalities , Trisomy , Eye Abnormalities/pathology , Humans , Infant , Iris/pathology , MaleABSTRACT
PURPOSE: To report a child with extensive bilateral hyperplastic pupillary membranes and good visual acuity. METHOD: We examined a 9-year-old child with bilateral hyperplastic persistent pupillary membranes present since birth. RESULTS: The patient had a visual acuity of BE, 20/30, stereopsis of 50 seconds of arc, orthophoria, and normal extraocular movements. The remainder of the ophthalmic examination was normal. CONCLUSION: Patients with bilateral hyperplastic pupillary membranes may not require surgical intervention.
Subject(s)
Iris/pathology , Child , Depth Perception/physiology , Eye Movements , Female , Humans , Hyperplasia/pathology , Membranes , Pupil , Visual Acuity/physiologyABSTRACT
Two patients with lymphedema-distichiasis syndrome illustrate that both Milroy's disease and late-onset hereditary lymphedema are sometimes associated with distichiasis. It is important for ophthalmologists to be aware of the lymphedema-distichiasis syndrome because of its ophthalmic manifestations and the associated systemic abnormalities that can be potentially life threatening.
Subject(s)
Eyelashes/abnormalities , Lymphedema/genetics , Adolescent , Conjunctival Diseases/complications , Corneal Diseases/complications , Female , Humans , Male , Pigmentation Disorders/complications , SyndromeABSTRACT
We present a rapid method for fixation of split-thickness skin grafts to the exenterated orbit using Steri-Strips and tincture of benzoin.