[Bronchial hypersensitivity in children with the neutrophilic phenotype of bronchial asthma and GSTM1 and GSTT1 gene polymorphism].

INTRODUCTION: The relationship between bronchial hypersensitivity as the key phenomenon ofbronchial asthma and detoxication GSTM1 or GSTT1 gene polymorphism in children with neutrophilic phenotype of this disease remains unclear MATERIALS AND METHODS: 33 children with bronchial asthma of neutrophile phenotype were examined in histamine and dosed physical exercise (running) tests. In addition GSTM1 and GSTT1 genotyping was performed. RESULTS: Histamine test revealed bronchial hypersensitivity (HTC < 0.3 mg/ml) in 30.7% of the children with GSTMI and/or GSTTI deletions versus 12.5% of those without deletions (P phi < 0.05). The relative risk ofhypersensitivity to histamine (HTC < 0.3 mg/mI) in the presence of deletions was estimnated as 3.1 (95% CI 1.4-6.4), at OR 2.4 (95% CI 1.08-3.1) andAR = 0.18. CONCLUSION: Children with the neutrophilic phenotype of bronchial asthma having deletions in the GSTT1/GSTM1 system are characterized by bronchial hypersensitivity to histamine and dosed physical exercises.

[The assessment of the efficacy of calcium antagonists in the treatment of children with repeated episodes of the broncho-obstructive syndrome]. / Otsenka éffektivnosti antagonistov kal'tsiia v lechenii detei s povtornymi épizodami bronkhoobstruktivnogo sindroma.

Overall seventy-five schoolchildren with a history of no less than 4 episodes of impassability commonly against the afebrile background were examined. The results obtained suggest that the greatest reduction in the relative risk of bronchial unspecific hyperreactivity manifestations with calcium antagonists being ingested occurs in those children experiencing recurrent episodes of bronchial obstruction in the presence of marked lability of the bronchi that is commonly associated with the atopic genesis of their obstruction.