ABSTRACT
The long-term effects of sodium nitrite (NaNO2) on carcinogenesis induced by urethane (total dose 1.0 mg/g body weight) in low-grade cancer F1 (C57BLxCBA) and high-grade A/Snell mice and on viral (Rausher leukemia virus) leukomogenesis in Balb/c mice. The murine intake of NaNO2 with water (50 mg/l) causes a statistically significant increase in the number of adenomas in the lung. Examining the mechanism of conversion of NO2- to NO led to the assumption that the free radical compounds NO and NO2 are involved in the potentiating action of NO2 on blastomogenesis. The use of the oxidant emoxypine (3-hydroxypyridine) confirmed the above. The role of NO and NO2 in the intracellular processes under the modifying effects of nitrites and nitrates on blastomogenesis is analyzed.
Subject(s)
Leukemia Virus, Murine/pathogenicity , Leukocytes/virology , Lung/pathology , Lymphocyte Activation/drug effects , Nitric Oxide/pharmacology , Nitrogen Dioxide/pharmacology , Oxidants, Photochemical/pharmacology , Adenoma/chemically induced , Adenoma/metabolism , Adenoma/pathology , Animals , Antioxidants/pharmacology , Carcinogenicity Tests , Female , Leukemia Virus, Murine/drug effects , Leukocytes/drug effects , Leukocytes/metabolism , Leukocytes/pathology , Lung/drug effects , Lung/metabolism , Lung/virology , Lung Neoplasms/chemically induced , Lung Neoplasms/metabolism , Lung Neoplasms/pathology , Lymphocyte Activation/physiology , Mice , Mice, Inbred C57BL , Mice, Inbred CBA , Neoplasms, Experimental/chemically induced , Neoplasms, Experimental/metabolism , Neoplasms, Experimental/pathology , Nitrites/pharmacology , Picolines/pharmacologyABSTRACT
A study of the effect of sodium nitrite (SN) on leukemia development in mice induced by Rauscher Leukemia virus (RLV) (Balb/c mice), Mazurenko leukemia virus (MaLV) (CC57Br mice), and Gross leukemia virus (GLV) (AKR/J mice) was performed. SN was administered in water (at concentrations of 5.0, 50.0, 500.0, and 2000.0 mg/l, by NaNO2). A moderate, yet statistically significant acceleration of leukemia development was observed in some groups of SN-treated mice. Our findings and the literature provide evidence that SN has the capacity to enhance the carcinogenic effect of leukemia viruses in vivo.
