ABSTRACT
Injection of exogenic 5'-AMP to rats was accompanied by pronounced and transient adenosinemediated elevation of serum glucose concentration. Both efficiency and duration of the observed hyperglycemic effect were increased within the first week after single whole-body gamma-irradiation (137Cs) of the animals at 1 Gy dose. These data suggest modification of purinergic regulation of some processes of carbohydrate metabolism and disturbance of the organism tolerance towards the glucose following 1 Gy gamma-irradiation.
Subject(s)
Adenosine Monophosphate/administration & dosage , Blood Glucose/analysis , Blood Glucose/radiation effects , Animals , Male , Radiation Dosage , Rats , Whole-Body IrradiationABSTRACT
Studies were carried out to investigate the activity of ATPase and ADPase in rat blood serum after strong (137Cs) on the rate of 1 Gy. Rats were examined for various postirradiation periods up to 3 months. Two-fold decreasing of serum ATPase activity was recorded within the two weeks after gamma-irradiation. The rate of 3H-ADP enzymatic hydrolysis in the serum of irradiated animals remained unchanged as compared to controls.