ABSTRACT
The goal was to determine clinical and genealogical and pathophysiological markers of the risk recurrent depression development risk. Clinical and psychopathological, genealogical, psychometric (Montgomery-Asberg Depression Rating Scale - MADRS), "Psychological Autobiography" method (Burlachuk L.F., Korzhova E.Yu., 1998), methods of mathematical statistics. A survey of 108 patients with recurrent depression (ICD10, F33.0-33.2) compared with 46 individuals in the general population, found a high level of family burden of depression, at all degrees and levels of relatedness with recurrent depressive disorder in the patients' parentage. Thus, it is shown that the patients' percentage that has been placed on a psychiatric register (18%, CI: 14.5-22.1) was 15 times higher than in the comparison group (p <0.05), patients with depression (33%, CI: 28.5-37.8) - 7.3 times higher (p <0.05), suicide (7.9%, CI: 5.6-11.0) - in 4.2 times higher (p<0.05), cases of alcohol dependence (25.6%, CI: 21.6-30.2) - 1.8 times higher (p<0.05). According to the results of the statistical analysis, it has been determined that both hereditary and sociopsychological factors act as predictors of depression, which increase the probability of depression's developing risk or anti-risk. The most informative signs of the arising depression risk were: observation by a psychiatrist (DC=-5.78, MI=1.40), the presence of depression (DC=-8.69, MI=1.24), suicidal behavior (DC=-6.15), MI=0.18) and alcohol dependence (DC=-2.53, MI=0.14) in the probands' parentage, the presence of a high level in the subjective life negative events' perception path related to health (their or relatives) (DC=-2.83, MI=0.23) in patients. The data obtained indicate the following - the formation and development of depressive pathology due to the hereditary factors influence combined with patient's psychological state negative features (high level in the subjective perception of the life path negative health events (own or loved ones).
Subject(s)
Depressive Disorder, Major , Suicide , Depression/epidemiology , Humans , Psychiatric Status Rating Scales , Psychometrics , Suicidal IdeationABSTRACT
We estimated the efficacy of Brizantin preparation in suppressing nicotine dependence in rats. It was shown that nicotine-dependent rats in the situation of choice between the chamber with smoke or the chamber with food more frequently entered the chamber with tobacco smoke and stayed there longer. The rats that received Brizantin demonstrated significantly fewer visits to the chamber with smoke and spent there less time. Reduced locomotor activity and orientation and exploratory behavior in rats against the background of Brizantin administration also suggest reduced motivation for smoke inhalation. Thus, Brizantin effectively diminished nicotine dependence in rats in the model of nicotine addiction.
Subject(s)
Antibodies/therapeutic use , Choice Behavior/drug effects , Drug Combinations , Exploratory Behavior/drug effects , Tobacco Use Disorder/drug therapy , Animals , Food Deprivation , Hunger , Male , Motivation , Nicotine , Rats , Self Administration , Smoke , Smoking/drug therapy , NicotianaABSTRACT
We studied the effect of potentiated antibodies to morphine (10(-100) wt %) on self-stimulation of the lateral hypothalamus and behavioral reactions reflecting the severity of withdrawal syndrome in rats with morphine dependence. Repeated treatment with potentiated antibodies to morphine increased the rate of self-stimulation, suppressed active avoidance response, promoted freezing behavior after acoustic stimulation, and decreased tail-flick latency in rats after morphine withdrawal. Distilled water did not produce these changes.
