ABSTRACT
This paper examines a case of pleomorphic primitive neuroectodermal tumor (PNET) with glial and neuronal differentiation in a 7-year-old girl who was clinicopathologically reported with immunohistochemical and chromosomal analysis. Clinically, a highly aggressive behavior leading to early recurrence with cerebrospinal fluid seedings was characteristic despite total removal and chemoradiation therapy. Pathologically, severe pleomorphism was noted and large ganglioid cells were predominant. Immunohistochemically, the expression of low-molecular neurofilament was recognized in the surgical specimens and increased in the recurrence. Coexpression of vimentin and neurofilament/GFAP was recognized in the culture. Chromosomal analysis showed near-diploidy, but different karyotype from that PNETs previously reported. These findings suggested that PNETs with pleomorphism and differentiation into both glial and neuronal lineages may show aggressiveness and require more aggressive therapy.
Subject(s)
Brain Neoplasms/genetics , Brain Neoplasms/pathology , Chromosome Mapping , Neuroectodermal Tumors, Primitive, Peripheral/genetics , Neuroectodermal Tumors, Primitive, Peripheral/pathology , Neuroglia/pathology , Neurons/pathology , Brain Neoplasms/diagnosis , Brain Neoplasms/metabolism , Cell Differentiation , Child , Diploidy , Female , Humans , Immunohistochemistry , Karyotyping , Magnetic Resonance Imaging , Neoplasm Recurrence, Local/genetics , Neoplasm Recurrence, Local/metabolism , Neoplasm Recurrence, Local/pathology , Neuroectodermal Tumors, Primitive, Peripheral/diagnosis , Neuroectodermal Tumors, Primitive, Peripheral/metabolismABSTRACT
The correlation between event-related potentials (P300) and activities of daily living was studied in Parkinson's disease. The P300 of 30 patients with Parkinson's disease and 118 normal subjects were recorded. All patients were evaluated by the Mini-Mental State, Kana-hiroi Test, word fluency, Raven's Coloured Progressive Matrices, Osaka Memory Scale, revised Wechsler Adult Intelligence Scale, self-rating depression scale, state-trait anxiety inventory, and Functional Independence Measure. Eight patients showed prolonged P300 latencies. P300 latency showed relationships to the Mini-Mental State (p < 0.05) and cognitive items of the Functional Independence Measure (p < 0.05). P300 amplitude showed a relationship to performance IQ (p < 0.005), Raven's Coloured Progressive Matrices (p < 0.01) and motor items of the Functional Independence Measure (p < 0.05). It was concluded that P300 should be useful in predicting difficulties with activities of daily living in patients with Parkinson's disease.
