[Gastrointestinal hemorrhages as a consequence of the side effects of drug substances]. / Zheludochno-kishechnye krovotecheniia vsledstvie pobochnogo deistviia lekarstvennykh veshchestv.

The authors observed 53 cases of profuse gastroinstestinal bleeding resulting from the use of "ulcerogenic" drugs (reserpine, prednisolone, butadione, acetylsalycylic acid) for hypertensive disease, bronchial asthma, infections polyarthritis, influenza etc. The active but temporizing therapeutic tactics was applied. Of 53 cases of profuse gastrointestinal bleeding 48 survived (90.6%) and 5 died (9.4%).

[Various indicators of water-electrolyte metabolism in ulcer and cancer of the stomach]. / Nekotorye pokazateli vodno-elektrolitnogo obmena pri iazvennoi bolezni i rake zheludka.

101 patients suffering ulcerous disease and cancer of the stomach were examined. Disorders in water-electrolyte metabolism were revealed, these being aggravated in the postoperative period, especially at the 3d--5th day following the operation. The aimed correction of the disorders concerned was made. The best results were obtained under the correction, made on the basis of absolute indices of water-electrolyte metabolism disorders.

[Viability of the kidney following autovenoplasty of its artery]. / Zhiznesposobnost' pochki posle autovenoplastiki ee arterii

A segment of one of the renal arteries of the dog was substituted for a piece of the femoral vein of the same dog. Along the site of vascular anastomoses the kidney was excluded from general blood circulation. The results of the vessel plastics were not always favourable. Inspite of the independence of anastomoses in the course of operation, the lumen of the substituted piece of the renal artery underwent deformity in a number of experiments, the circulation of the kidney was disturbed, the parenchyma of the organ was injured, a part of renal bodies and tubules were atrophied, intraorganic vessels, especially glomeruli were reconstructed. The alterations were of focal character. In general the structure of the kidney was preserved. In most experiments the substitution of the renal artery for the own vein did not cause any disorders. The wall of the transplanted vein was soon reconstructed--artealized, the renal parenchyma kept normal structure. The success of vascular plastics and the full value of blood circulation was controlled by removing the twin organ. Animals with one kidney lived practically unlimited time without obvious disorders, the content of nitrogen in the blood was normal, no alterations were found in intraorganic vessels and the renal parenchyma.

[Treatment of diabetic gangrene]. / Lechenie diabeticheskoi gangreny

The results of treatment in 68 patients with vascular lesions of the lower limbs in diabetes mellitus are analysed. Fifty patients showed a necrotic and gangrenous stage of the disease. A grave form of diabetes was observed in half of them. In every case of diabetic angiopathy of the lower extremities vessels, irrespective of the gravity and stage of the process, insulinotherapy should be instituted. A complex therapy and preoperative management also include an adequate physiological diet, spasmolytics, vitamins, antibiotics according to an antibioticogram, and anticoagulants, local enzymotherapy, if indicated. In 13 cases spontaneous sequestration occurred, 31 patients were operated upon: sequestration--in 6, amputation--in 25. The operation was performed after elimination of auetonuria and ketonuria and reduction of hyperglycemia as low as 200 mg% (the latter was gained but not always). Recently, low amputations have been accomplished more frequently than before. No postoperative mortality was noted.