ABSTRACT
The results of 5-year observations on the duration of immunity to measles virus in persons vaccinated and revaccinated against measles, as well as in persons having had this infection, are presented. The intensity of immunity was determined in the same persons with the use of the passive hemagglutination test. The study revealed differences in the formation, intensity and duration of postvaccinal immunity. A significant decrease in the concentration of antibodies over the period of 5 years was established in 50.0-52.3% of vaccines. Revaccination with live measles vaccine is an effective measure for enhancing immunity to measles virus in persons with initial antibody titers less than 1:10-1:20, but revaccination made in a single injection is not sufficient for the stable maintenance of measles morbidity at the sporadic level. Postinfectious immunity is characterized by stability and has no tendency towards decrease. Persons having had measles have no need in additional measures irrespective of the time elapsed after the disease.
Subject(s)
Immunization, Secondary , Measles Vaccine/immunology , Measles/immunology , Antibodies, Viral/blood , Antibody Formation , Child , Convalescence , Humans , Measles/prevention & control , Measles virus/immunology , Time Factors , Ukraine , Urban PopulationSubject(s)
Disease Outbreaks/prevention & control , Measles Vaccine/immunology , Measles/prevention & control , Population Surveillance/methods , Referral and Consultation , Age Factors , Antibodies, Viral/analysis , Humans , Immunization, Secondary , Measles/epidemiology , Measles virus/immunology , Ukraine/epidemiology , Urban Population/statistics & numerical dataABSTRACT
The authors studied the reactigenic properties, immunological and epidemiological efficacy of vaccination of children aged under one year by the experimental schemes (AKDC-AKDC-K -- 1 ml, and AKDC-AKDC-K -- 0.5 ml) in comparison with the official pertussis, diphtheria, and tetanus immunization scheme. There proved to be a greater immunogenicity and a better protective effect against pertussis in vaccination according to the experimental schemes. The vaccine reactions were somewhat more incident in children vaccinated according to the AKDC-AKDC-K -- 1 ml scheme, but their essential reduction was reached with reduction of the pertussis antigen third vaccination dose to 0.5 ml.