ABSTRACT
The mandible shape of the common vole semi-species from the hybrid zone was studied for the first time using the methods of geometric morphometry. The hybrid specimens were found to display high morphological variability being closer to the parental Microtus obscurus than to M. arvalis form. The main trends of changes in the mandible shape were primarily observed in the horizontal plane.
Subject(s)
Arvicolinae/anatomy & histology , Arvicolinae/genetics , Mandible/anatomy & histology , Animals , Species SpecificityABSTRACT
Official medical statistics have been analysed corcerning overall urological morbidity in the Russian Federation (RF) and in some particular regions of the RF. The analysis covered morbidity and mortality from urogenital diseases including glomerular, tubulointersticial and other diseases of the kidneys and ureter, prostatic diseases, male infertility, cancer of the urinary bladder and prostatic gland. It was found that information on urological and oncourological morbidity in the literature is available but its amount is not satisfactory. It is necessary to introduce innovations in organization of medical statistical service, in registration of urological diseases, in particular. Active screening for urological cancer in the RF does not meet requirements and potentialities of modern health care. Special screening programs must be designed to reduce mortality and improve follow-up of urological patients.
Subject(s)
Female Urogenital Diseases/epidemiology , Male Urogenital Diseases/epidemiology , Female , Female Urogenital Diseases/mortality , Humans , Incidence , Male , Male Urogenital Diseases/mortality , Russia/epidemiologyABSTRACT
The level of vitamin E was measured in 31 renal carcinomas and unaffected renal cortex taken as control. Two groups were formed in respect to cell composition of the carcinoma: 14 tumors composed of clear cells; 17 tumors composed of other types cells. Vitamin E concentrations and total lipids in the tumor tissue were elevated. Despite a significant positive correlation between levels of vitamin E and lipids in cancer tissue, high content of lipids is not the main reason of vitamin E accumulation. Concentration of vitamin A measured in 17 carcinomas was similar to control as per 1 mg of tissue lipids. Blood levels of vitamin E and total lipids in 12 patients with renal cell carcinoma were significantly higher than in healthy subjects and returned to normal after nephrectomy.
Subject(s)
Carcinoma, Renal Cell/chemistry , Kidney Neoplasms/chemistry , Lipids/analysis , Vitamin A/analysis , Vitamin E/analysis , Adult , Aged , Carcinoma, Renal Cell/surgery , Female , Humans , Kidney Cortex/chemistry , Kidney Neoplasms/surgery , Male , Middle Aged , Nephrectomy , SolubilityABSTRACT
Clinical manifestations were compared in coronary patients with different sites and spread of coronary atherosclerosis, in order to assess the feasibility of differential diagnosis of left coronary arterial (LCA) trunk lesions versus multiple coronary arterial stenoses. Four groups of patients were examined: isolated third- or fourth-degree LCA trunk stenosis (15 patients, group 1); third- or fourth-degree stenosis of the anterior interventricular branch (AIVB) and the circumflex branch (CB) (44 patients, group 2); third- or fourth-degree stenosis of AIVB, CB or the right coronary artery (RCA) (77 patients, group 3); and third- or fourth-degree stenosis of AIVB, CB, the diagonal branch or RCA (33 patients, group 4). The clinical condition of patients with isolated LCA branch lesions was much worse than that of patients with multiple coronary arterial stenosis. Differential diagnosis is based on the severity of the pain syndrome, the spread of ischemic zone on resting ECG, the scope of past myocardial infarction, stress tolerance and the magnitude of ST depression in response to exercise.
Subject(s)
Coronary Disease/diagnosis , Constriction, Pathologic/diagnosis , Constriction, Pathologic/physiopathology , Coronary Vessels/pathology , Coronary Vessels/physiopathology , Diagnosis, Differential , Electrocardiography , Exercise Test , Female , Hemodynamics , Humans , MaleABSTRACT
A study was made of the results of surgery of 37 patients and conservative therapy of 90 patients (including 53 inoperable cases) with coronary heart disease with the involvement of the left main coronary artery. Lethality in a long-term period was 16.2% in the operated patients and 45.6% in the inoperable patients. A considerable improvement of the status with the lessening or disappearance of angina attacks was noted in 27 operated patients (87%), a stable improvement of ECG at rest and a considerable increase in exercise tolerance were noted in 11 patients. There was no considerable improvement of the status in the inoperable patients, a slight decrease in the number of attacks was noted in 22% of the patients only, impairment of ECG at rest was noted in 52%, exercise tolerance decreased in most of the patients. In the operated patients the 7-year survival rates according to actuarial curves were 81%, in the operable but receiving conservative therapy 47% and in the inoperable patients 34%.
Subject(s)
Coronary Artery Bypass , Coronary Disease/therapy , Adrenergic beta-Antagonists/administration & dosage , Anabolic Agents/administration & dosage , Cardiac Glycosides/administration & dosage , Drug Therapy, Combination , Follow-Up Studies , Humans , Middle Aged , Nitrates/administration & dosage , Work Capacity EvaluationABSTRACT
Using an information system, the authors compared the results of the examination of 169 patients with coronary heart disease and left coronary artery trunk lesions and of 605 patients without such lesions. The functioning of the system was controlled by a complex of programmes designed according to the modular principle. It comprises the following modules: modules of the formation and control of the data pool, modules of the formation of sub-pools according to a given set of signs and modules of data processing. The patients with coronary heart disease and a lesion of the left coronary artery trunk had a number of clinical characteristics including frequent and severe anginal attacks, a large zone of myocardial ischemia, a low exercise tolerance and a considerable depression of the ST segment on the ECG, as well as a long rehabilitation period.
Subject(s)
Coronary Disease/diagnosis , Diagnosis, Computer-Assisted , Adult , Aged , Angina Pectoris/diagnosis , Chronic Disease , Coronary Angiography , Electrocardiography , Humans , Middle AgedABSTRACT
The case histories, painful syndromes, clinical pictures, ECG at rest, and the exercise ECG test data were examined in 169 patients with degrees I-IV of left coronary artery stenosis. The gravity of the clinical picture was found to be augmented with the stenosis degree. The number of daily angina pectoris attacks and their gravity increased, while the pains at rest, night time, after meal, and during transition from the vertical to the horizontal position occurred more frequently. As the stenosis degree progressed, the coronary insufficiency area on the ECG at rest became larger. The exercise tolerance threshold appeared particularly low in patients with degrees II-IV of stenosis, being slightly higher in those with degree I of stenosis. The number of patients who survived myocardial infarction declined with stenosis progression. Patients with degree I of stenosis manifested a grave clinical picture. Stenosis of the left coronary artery up to 50% of the initial trunk was a clinically significant lesion.
Subject(s)
Coronary Disease/diagnosis , Coronary Vessels , Angina Pectoris/diagnosis , Constriction, Pathologic , Coronary Disease/classification , Electrocardiography , HumansABSTRACT
The effect of aggravated heredity for coronary heart disease on the extent of coronary arterial damage and the course of the disease was studied in 575 coronary patients. An information system based on the findings was treated on a third-generation computer M-4030. Coronary patients with aggravated heredity showed high rates of coronary arteries narrowing, more severe course of the disease and frequent large-focal myocardial infarctions with aneurysms of the heart.
Subject(s)
Coronary Disease/genetics , Adult , Aged , Coronary Angiography , Coronary Disease/diagnosis , Coronary Disease/etiology , Coronary Vessel Anomalies/diagnosis , Disease Susceptibility , Female , Humans , Male , Middle AgedABSTRACT
A relationship was studied between the intensity of smoking and changes revealed in the coronary arteries by coronarography in 498 patients with ischemic heart disease. Marked atherosclerosis was found in 94% of "regular" smokers and in 69% of the persons who did not smoke or smoked only a little. A particularly clear connection between the intensity of smoking and affection of the coronary arteries was registered in patients with ischemic heart disease under the age of 40. All of them had grades III and IV stenosis of the coronary arteries. The results discussed confirm that smoking is a serious "risk factor" of the development of ischemic heart disease, especially in young individuals.
