ABSTRACT
Evoked response audiometry was carried out to assess the viability of the auditory pathway in haemodialysed patients. The latency of the waves III and V and I-V interpeak latencies were significantly longer in the renal patients compared to the control group. The I-V interpeak latency was longer in 8 of our 13 patients than the upper limit (4.38 ms) in our laboratory. The possible cause for the central auditory dysfunction may be multifactorial, including the effect of metastatic calcifications, repeated occurrence of disequilibrium syndrome, or some small, molecular, toxic, metabolic substance. The significance of the different factors may vary among different haemodialysis centres.
Subject(s)
Evoked Potentials, Auditory, Brain Stem/physiology , Uremia/physiopathology , Adult , Audiometry, Evoked Response , Auditory Threshold/physiology , Female , Hearing Loss, High-Frequency/diagnosis , Hearing Loss, High-Frequency/physiopathology , Hearing Loss, Sensorineural/diagnosis , Hearing Loss, Sensorineural/physiopathology , Humans , Male , Middle Aged , Recruitment Detection, Audiologic , Renal DialysisABSTRACT
Ipriflavone (7-isopropoxy-isoflavone) was attempted to relieve tinnitus of otosclerotic patients prior to stapedectomy and continuing the treatment postoperatively in a 6 months regimen. As a whole the double-blind study revealed effectiveness of Ipriflavone in the control of tinnitus when preoperatively administered as well as in combination with stapedectomy. The small number of cases (9 patients treated with Ipriflavone and 7 patients with placebo) needs further confirmation of the present data. Predominantly low-tone tinnitus rises the possibility of its cochlear origin in otosclerosis, as a consequence of mechanical or hydrodynamic causes or hydrostatic pressure elevation due to spread of the otosclerotic focus onto the cochlear duct.
Subject(s)
Isoflavones/therapeutic use , Otosclerosis/surgery , Tinnitus/drug therapy , Adult , Audiometry, Pure-Tone , Combined Modality Therapy , Double-Blind Method , Humans , Middle Aged , Otosclerosis/complications , Otosclerosis/physiopathology , Premedication , Stapes Surgery , Tinnitus/etiologyABSTRACT
The authors carried out BERA examinations in 46 children difficult to test. Seven cases are described in detail. In connection with these cases attention is drawn to the unforeseeable difficulties of this examination method used already widely.
Subject(s)
Hearing Disorders/diagnosis , Child , Child, Preschool , Evoked Potentials, Auditory, Brain Stem , Hearing Disorders/physiopathology , Humans , InfantSubject(s)
Gonadal Dysgenesis/genetics , Adolescent , Adult , Female , Genes, Recessive , Humans , Karyotyping , Syndrome , X ChromosomeABSTRACT
The prevalence and severity of hearing impairment caused by ototoxic drugs are surprisingly high. This emphasizes the importance of the questions arising from the treatment. In 33.7% of the cases, the hearing impairment caused by ototoxic antibiotics was of severe degree and in 25.4%, it was extremely severe. Parenteral, topical or oral administration of aminioglycoside antibiotics is dangerous. Because of the very poor speech intelligibility, most probably not only the spiral organ but the vestibulocochlear nerve and the higher auditory pathways are also affected by these antibiotics. In some cases, the severe distortion in sound perception cannot be compensated even by a hearing aid of the best quality, and lip-reading which was advised occasionally was without any result. To prevent these toxic effects, these drugs should be administered very parsimoniously and then under very strict conditions and close control.
