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Bull Exp Biol Med ; 162(2): 184-186, 2016 Dec.
Article in English | MEDLINE | ID: mdl-27909968

ABSTRACT

The period of forming of superficial vascular plexus during physiological retinal angiogenesis was shorter in C57Bl/6 mice. Experiments on the model of oxygen-induced retinopathy showed that avascular and vascularized zones in BALB/c mice on day 17 are smaller than in C57Bl/6 mice are by 5 and 1.5 times, respectively. The obtained results confirmed the importance of phenotype of retinal macrophages in the regulation of processes of both physiological and pathological retinal angiogenesis.


Subject(s)
Hypertensive Retinopathy/pathology , Macrophages/cytology , Neovascularization, Pathologic/pathology , Phenotype , Retina/pathology , Retinal Neovascularization/pathology , Animals , Fluorescein-5-isothiocyanate/chemistry , Hypertensive Retinopathy/chemically induced , Hypertensive Retinopathy/immunology , Immunohistochemistry , Immunophenotyping , Macrophages/classification , Macrophages/immunology , Mice , Mice, Inbred BALB C , Mice, Inbred C57BL , Neovascularization, Pathologic/chemically induced , Neovascularization, Pathologic/immunology , Neovascularization, Physiologic/immunology , Oxygen/adverse effects , Plant Lectins/chemistry , Retina/immunology , Retinal Neovascularization/chemically induced , Retinal Neovascularization/immunology , Species Specificity , Streptavidin/chemistry
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