[A uniform approach to the synthesis of carbohydrate conjugates of polyhedral boron compounds as potential agents for boron neutron capture therapy].

A uniform approach to the synthesis of carbohydrate conjugates with polyhedral boron compounds (PBCs) was developed. Oligosaccharide derivatives with an aglycone moiety amino group can be coupled with PBC carboxyl derivatives using N-methyl-N-(4,6-dimethoxy-1,3,5-triazin-2-yl)morpholinium chloride as a coupling agent. Both N- and O-glycosides differing in the conformational mobility around the glycoside bond were shown to be useful as oligosaccharides with a functional group in the aglycone moiety. This allows the application of this approach to the synthesis of PBC conjugates with a wide range of oligosaccharides. For example, not only oligosaccharides obtained by chemical synthesis but also reducing oligosaccharides isolated from natural sources can be transformed into N-glycosides. The approach was tested by the example of conjugation of the carboxyl derivatives of ortho-carborane and dodecaborate anion with lactose as a model oligosaccharide. Lactose, an easily available disaccharide, is a ligand for lectins expressed on the surface of melanoma cells. The approach suggested is the first example of the synthesis of such conjugates that does not require protective groups for the carbohydrate residue. It is especially important for obtaining dodecaborate-carbohydrate conjugates for which the removal of protective groups is often a non-trivial task.

[Improving the organization of primary health care for invalids with impaired vision]. / Sovershenstvovanie organizatsii pervichnoi mediko-sanitarnoi pomoshchi invilidam po zreniiu.

The results of the work of 6 health posts at electrical engineering plants of the Ukrainian Society of treh Blind are presented. The number of attendencies for invalids with eyesight disorders constituted 29.5 annually, for those with good eyesight it was 6.7. Time losses for a curative and diagnostic consultation and provision of medical care to invalids of the Ist group with eyesight disorders exceeded the time necessary for rendering care to those who could see by 31-34%. Feldshers spent 43.6% of their working time and medical nurses 65.3% on medical care. Attendencies associated with psychic disorders were listed as one of the biggest health problems in the disease pattern of the blind and those with weak eyesight, 91.1% of psychic cases being attributed to vegeto-vascular dystonia, diseases of the circulatory system, injuries and their aftereffects. A set of proposals was developed, thus it became possible to regulate the work of the health personnel of health posts at the enterprises belonging to the Society of the Blind.