[A role of the HLA-DRB1* genotype in the complex therapy of pulmonary tuberculosis].

It is as for now evident that in-depth researches of the genotype of a patient are needed to enhance the efficiency of therapeutic measures. The purpose of the present study was to enhance the efficiency of complex antituberculous therapy, by genetically identifying the allelic polymorphism of the HLA-DRB1* gene in a person who had ill with tuberculosis. The material of the study was the results of a followup and treatment of 100 patients with pulmonary tuberculosis. The subject of a special study was the molecular typing of the HLA genes of the DRB1* locus by polymerase chain reaction (PCR-SSP). The findings suggest that an individual approach to choosing treatment regimens (chemotherapy and pathogenetic therapy) for patients with pulmonary tuberculosis, by taking into account the HLA-DRB1* genotype enables one to enhance the efficiency of treatment in the major clinical and X-ray parameters.

[Role of a comprehensive genetic prognosis in the treatment and prevention of respiratory tuberculosis in adolescents].

The paper presents the results of a follow-up and treatment of 75 adolescents with pulmonary tuberculosis. It assesses the predictive value of different alleles of the gene HLA-DRB1 and the genotype of Mycobacterium tuberculosis for the clinical course of pulmonary tuberculosis in the adolescents. An algorithm of examination of an adolescent with tuberculosis has been developed, by using a complex of genetic parameters. A differential approach to tuberculosis prevention and treatment regimens is presented by taking into account of genetic characteristics of gross and microorganisms.

[Etiopathogenetic therapy in adolescent patients with drug-resistant Mycobacterium tuberculosis in respiratory tuberculosis]. / Etiopatogeneticheskaia terapiia bol'nykh tuberkulezom organov dykhaniia podrostkov s lekarstvennoi ustoichivost'iu mikobakterii tuberkuleza.

The progress and efficiency of different therapy regimens for respiratory tuberculosis and the genotyping of Mycobacterium tuberculosis (MBT) were clinically analyzed in 46 adolescents. The pathogen of the disease was MBT of the Beijing family in 20 patients and the individual genotype of MBT in 22 patients. It has been ascertained that MBT of the Beijing genotype (80%) was more commonly recorded in secondary tuberculosis, both MBT of the Beijing family (59.0%) and the individual genotype of the pathogen (41%) were in primary tuberculosis. When MBT of the Beijing family had been infected, progression was diagnosed as being 3 times more frequently [n = 12 (54.5%)] family than that with individual genotype infection [n = 3 (13.6%)]. Therapy regimens have been developed by taking into account drug resistance and the genotype of MBT, the degree of inactivation of GINK and bacteriostatic blood activity, their clinical efficiency proved.

[The activity of alpha2-macroglobulin and its forms in patients with destructive pulmonary tuberculosis]. / Aktivnost' alpha2-makroglobulina i ego form u bol'nykh destruktivnym tuberkulezom organov dykhaniia.

A hundred and three patients with destructive pulmonary tuberculosis were examined. These patients had heterodirectional changes in the serum levels of alpha2-macroglobulin (MG) and its forms. The lowering of the level of the F-form of the inhibitor outstripped the decrease in the activity of total alpha2-MG and it was detectable in the lobar processes with moderate symptoms of intoxication and with the inoculation of adjacent segments. The preservation of the low total activity of the inhibitor and its forms during antituberculous therapy characterize a diminished process. The high content of the S form of alpha2-MG is a feature in patients showing positive changes before and 2 months after treatment whereas the changes in total alpha2-MG and its F form may vary. Whether it is expedient to study the fractional composition of alpha2-MG is determined by the heterodirectionality of changes in its S and F forms depending on the pattern of a process.

[Effects of antiatherosclerosis diet including soy protein on the dynamics of clinical, biochemical and immunologic indicators in patients with ischemic heart disease and hypertension]. / Vliianie antiateroskleroticheskoi diety s vkliucheniem soevogo belka na dinamiku kliniko-biokhimicheskikh i immunologicheskikh pokazatelei u bol'nykh ishemicheskoi bolezn'iu serdtsa i gipertonicheskoi bolezn'iu.

Investigation of influence of diet with soy-protein on clinical and immune indices in patients with ischemic heart disease and hypertension was conducted. As a result of the diet modified by the protein component positive effect on the course of the diseases and lipid spectrum of blood, pronounced action on some indices of humoral immunity, intensity of processes of lipid peroxidation were observed.