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1.
Aust Dent J ; 63(2): 261-264, 2018 06.
Article in English | MEDLINE | ID: mdl-29281754

ABSTRACT

Peri-implant squamous cell carcinoma is an uncommon pathological manifestation, whereas peri-implantitis is commonly found in association with dental implants. Both present similarly with loss of supporting soft and hard tissue around dental implants; therefore, a careful differential diagnosis is required. The present case concerns a 62-year-old Japanese man who had a dental implant which had been in the left maxillary incisor region for 4 years who apparently developed peri-implantitis. This did not respond to localized therapy and antibiotics so was referred for specialist surgical management. A biopsy confirmed it to be a squamous cell carcinoma rather than an inflammatory lesion. A literature review shows that this is an unusual presentation without a previous history of malignancy, mucosal disease or risk factors for cancers. Although rare, the possibility of peri-implant squamous cell carcinoma should be borne in mind by all practitioners who monitor implant patients.


Subject(s)
Carcinoma, Squamous Cell/etiology , Dental Implants/adverse effects , Mouth Neoplasms/etiology , Peri-Implantitis/diagnosis , Biopsy , Humans , Inflammation , Japan , Male , Middle Aged , Risk Factors
2.
Int J Oral Maxillofac Surg ; 44(5): 664-9, 2015 May.
Article in English | MEDLINE | ID: mdl-25496849

ABSTRACT

The aim of this study was to investigate the capacity of human dental follicle cells (hDFCs) for bone formation in vivo. hDFCs were obtained from wisdom teeth extracted from patients aged 14 and 22 years. hDFCs from the 5th to 8th passages were grown in three-dimensional (3D) culture using gelatin sponges. Cells were transplanted onto the calvaria of F344/NJcl-rnu/rnu male rats (immunodeficient rats). Haematoxylin and eosin (HE) staining and immunohistochemistry were performed, and newly formed bone was evaluated by micro-computed tomography (micro-CT). HE staining showed newly formed bone in 3D culture. Immunohistochemistry showed bone morphogenetic protein 2 (BMP-2), runt-related transcription factor 2 (RUNX2), and osterix staining in areas with newly formed bone. Furthermore, micro-CT showed that, in comparison to controls, transplanted hDFCs promoted better bone quality and bone mineral density (BMD 582 ± 131.1 vs. 300.5 ± 77.7 mg/cm(3); P=0.039), bone mineral content (BMC 5.6 ± 1.1 vs. 2.1 ± 0.4 mg; P = 0.006), bone volume (BV 9.7 ± 0.5 × 10(-3) vs. 7.0 ± 0.4 × 10(-3) cm(3); P = 0.002), BMC/total volume (TV) (399.9 ± 76.3 vs. 147.7 ± 30.8 mg/cm(3); P = 0.006), and BV/TV (69.1 ± 3.6% vs. 49.6 ± 3.1%; P=0.002). This suggests that human dental follicles are potentially useful for regenerative therapy.


Subject(s)
Bone Regeneration/physiology , Dental Sac/cytology , Adolescent , Animals , Bone Morphogenetic Protein 2/metabolism , Core Binding Factor Alpha 1 Subunit/metabolism , Humans , Immunohistochemistry , Male , Pilot Projects , Rats , Rats, Inbred F344 , X-Ray Microtomography , Young Adult
3.
Rev Sci Instrum ; 85(7): 073704, 2014 Jul.
Article in English | MEDLINE | ID: mdl-25085143

ABSTRACT

Microbeam radiation therapy is an experimental form of radiation treatment with great potential to improve the treatment of many types of cancer. We applied a synchrotron radiation phase contrast technique to portal imaging to improve targeting accuracy for microbeam radiation therapy in experiments using small animals. An X-ray imaging detector was installed 6.0 m downstream from an object to produce a high-contrast edge enhancement effect in propagation-based phase contrast imaging. Images of a mouse head sample were obtained using therapeutic white synchrotron radiation with a mean beam energy of 130 keV. Compared to conventional portal images, remarkably clear images of bones surrounding the cerebrum were acquired in an air environment for positioning brain lesions with respect to the skull structure without confusion with overlapping surface structures.


Subject(s)
Radiography/instrumentation , Radiography/methods , Synchrotrons , Air , Animals , Equipment Design , Formaldehyde , Head/diagnostic imaging , Mice , Radiation Dosage , Skull/diagnostic imaging
4.
Rev Sci Instrum ; 83(7): 073302, 2012 Jul.
Article in English | MEDLINE | ID: mdl-22852680

ABSTRACT

Double-decker pulse radiolysis (DDPR), which utilizes double-decker electron beams, was investigated to develop a new pulse radiolysis with a high time resolution. The double-decker electron beams were generated by injecting two UV pulses into a photocathode radio-frequency gun. In the pulse radiolysis, one electron beam was used as a pump beam, and the other was converted to a probe pulse. Finally, as its first application, the DDPR was successfully used for observing solvated electrons in water, with a 10%-90% rise time of 8.6 ps.


Subject(s)
Electrodes , Lighting/instrumentation , Particle Accelerators , Pulse Radiolysis/instrumentation , Signal Processing, Computer-Assisted/instrumentation , Equipment Design , Equipment Failure Analysis
5.
Cell Tissue Res ; 350(2): 317-31, 2012 Nov.
Article in English | MEDLINE | ID: mdl-22890370

ABSTRACT

The dental follicle is an ectomesenchymal tissue that surrounds developing tooth germ and that contains osteoblastic-lineage-committed stem/progenitor cells. We examined the osteogenic potential of human dental follicle cells (hDFC) by microarray analysis. We first compared the characteristics of hDFC with those of human bone marrow mesenchymal stem cells (hMSC). Like hMSC, hDFC expressed stem cell markers such as STRO-1 and Notch-1 and differentiated not only into the osteoblastic lineage, but also into the adipogenic lineage. We analyzed the gene expression profiles of hDFC and hMSC that were not differentiated toward the osteogenic lineage. The expression of cell markers and growth factor receptors by hDFC and hMSC was similar, whereas the expression pattern of homeobox genes differed between hDFC and hMSC. Next, we investigated gene expression in hDFC during osteogenic differentiation. Gene expression profiles were analyzed in hDFC cultured in osteogenic induction medium (OIM) or in growth medium (GM) for 3 and 10 days. Many genes whose expression was regulated under these conditions were functionally categorized as "transcription" genes. Osteogenic markers were up-regulated in hDFC during osteogenic differentiation, whereas neurogenic markers were down-regulated. The genes whose expression was regulated in hDFC during osteogenic differentiation were further analyzed by ingenuity pathway analysis and real-time polymerase chain reaction. Bone morphogenetic protein and transforming growth factor-ß signaling pathways were activated in hDFC cultured in OIM for 3 days. This study indicates that the dental follicle contains stem cells and/or osteoblastic progenitor cells and is a potential cellular resource for bone regeneration therapy.


Subject(s)
Dental Sac/cytology , Mesenchymal Stem Cells/cytology , Osteogenesis/physiology , Adolescent , Cell Differentiation/physiology , Dental Sac/metabolism , Female , Gene Expression Profiling , Humans , Immunohistochemistry , Mesenchymal Stem Cells/metabolism , Osteogenesis/genetics , Real-Time Polymerase Chain Reaction , Signal Transduction
6.
Neuroscience ; 196: 97-103, 2011 Nov 24.
Article in English | MEDLINE | ID: mdl-21930190

ABSTRACT

l-glutamate, an umami taste substance, is a key molecule coupled to a food intake signaling pathway. Furthermore, recent studies have unveiled new roles for dietary glutamate on gut-brain axis communication via activation of gut glutamate receptors and subsequent vagus nerve. In the present study, we mapped activation sites of the rat forebrain after intragastric load of 60 mM monosodium l-glutamate (MSG) by measurement of Fos protein, a functional marker of neuronal activation. The same concentration of d-glucose (sweet) and NaCl (salty) was used as controls. MSG administration exclusively produced enhanced Fos expression in four hypothalamic regions (the medial preoptic area, lateral hypothalamic area, dorsomedial nucleus, and arcuate nucleus). On the other hand, glucose administration exclusively enhanced Fos induction in the nucleus accumbens. Both MSG and glucose enhanced Fos induction in three brain regions (the habenular nucleus, paraventricular nucleus, and central nucleus of the amygdala). However, MSG induced Fos inductions were more potent than those of glucose in the habenular nucleus and paraventricular nucleus. Importantly, the present study identified for the first time two brain areas (the paraventricular and arcuate hypothalamic nuclei) that are more potently activated by intragastric MSG loads compared with glucose and NaCl. Overall, our results suggest significant activation of a neural network comprising the habenular nucleus, amygdala, and the hypothalamic subnuclei following intragastric load with glutamate.


Subject(s)
Brain/physiology , Glucose/pharmacology , Prosencephalon/physiology , Proto-Oncogene Proteins c-fos/biosynthesis , Sodium Chloride/pharmacology , Sodium Glutamate/pharmacology , Taste Perception/physiology , Animals , Brain/drug effects , Brain/metabolism , Glucose/administration & dosage , Instillation, Drug , Male , Neural Pathways/drug effects , Neural Pathways/metabolism , Neural Pathways/physiology , Prosencephalon/drug effects , Prosencephalon/metabolism , Rats , Rats, Wistar , Sodium Chloride/administration & dosage , Sodium Glutamate/administration & dosage
7.
Rev Sci Instrum ; 81(10): 10D308, 2010 Oct.
Article in English | MEDLINE | ID: mdl-21033834

ABSTRACT

Microfission chambers (MFCs) will measure the total neutron source strength in ITER. The MFCs will be installed behind blanket modules in the vacuum vessel (VV). Triaxial mineral insulated (MI) cables will carry signals from the MFCs. The joint connecting triaxial MI cables in the VV must be considered because the MFCs and the MI cables will be installed separately at different times. Vacuum tight triaxial connector of the MI cable has been designed and a prototype has been constructed. Performance tests indicate that the connector can be applied to the ITER environment. A small bending-radius test of the MI cable indicates no observed damage at a curvature radius of 100 mm.

8.
J Dent Res ; 89(10): 1117-22, 2010 Oct.
Article in English | MEDLINE | ID: mdl-20647497

ABSTRACT

Synovitis, which is characterized by the infiltration of inflammatory cells, often accompanies progression of temporomandibular joint disorder (TMD) symptoms. Because IL-1ß is elevated in synovial fluids obtained from TMDs, we hypothesized that IL-1ß-responsive genes in synoviocytes may help identify the putative genes associated with synovitis. Using microarray analysis, we found that monocyte chemoattractant protein-1 (MCP-1) mRNA levels were elevated in IL-1ß-stimulated synoviocytes. MCP-1 is a member of the chemokine superfamily. The production of MCP-1 was increased in synoviocytes treated with IL-1ß. When IL-1ß was injected into the cavities of rat TMJs, inflammatory cells and MCP-1-positive cells were detected in the synovial tissues. Furthermore, MCP-1 levels were higher in synovial fluids from individuals with pain compared with those without pain. Inhibitors of MAP-kinases and NF-κB reduced IL-1ß-induced MCP-1 production. These results suggest that MCP-1 stimulated by IL-1ß is one of the factors associated with the inflammatory progression of TMDs.


Subject(s)
Chemokine CCL2/analysis , Temporomandibular Joint Disorders/immunology , Adolescent , Adult , Animals , Anthracenes/pharmacology , Autoantigens/analysis , Autoantigens/drug effects , Calcium-Calmodulin-Dependent Protein Kinases/antagonists & inhibitors , Cell Culture Techniques , Chemokine CCL2/drug effects , Cytokines/analysis , Cytokines/drug effects , Female , Flavonoids/pharmacology , Humans , Interleukin-1beta/antagonists & inhibitors , Interleukin-1beta/pharmacology , JNK Mitogen-Activated Protein Kinases/antagonists & inhibitors , Joint Dislocations/immunology , Male , Microarray Analysis , NF-kappa B/antagonists & inhibitors , Osteoarthritis/immunology , RNA, Messenger/analysis , Rats , Rats, Inbred Lew , Synovial Fluid/chemistry , Synovial Fluid/drug effects , Synovial Fluid/immunology , Synovial Membrane/drug effects , Synovial Membrane/immunology , Synovitis/immunology , Temporomandibular Joint Disc/immunology , Young Adult
9.
J Oral Pathol Med ; 38(7): 584-90, 2009 Aug.
Article in English | MEDLINE | ID: mdl-19141058

ABSTRACT

BACKGROUND: In this study, we analyzed the gene expression profile of fibroblast-like synoviocyte (FLS) cultures from the temporomandibular joint (TMJ) to identify candidate genes associated with intracapsular pathologic conditions of TMJ. Cyclooxygenase (COX)-2 was one of the genes in FLS upregulated following stimulation by interleukin (IL)-1beta, a cytokine thought to play a key role in several pathological conditions. This study investigated the expression of COX-1 and COX-2 in cultured human FLS and rat TMJ synovium following stimulation with IL-1beta. METHODS: RNA was isolated from human FLS after IL-1beta treatment. COX-1 and -2 expression was examined using a GeneChip and real-time polymerase chain reaction. Prostaglandin E(2) (PGE(2)) levels in conditioned media from FLS were measured using enzyme-linked immunosorbent assay. Synovial tissues from TMJs of IL-1beta-injected rats were examined for COX-1 and COX-2 expression by immunohistochemical staining. RESULTS: Following treatment of FLS with IL-1beta, expression of the COX-2 gene increased up to 8 h and peaked at 4 h, whereas COX-1 expression did not change. Stimulation with IL-1beta increased the level of PGE(2) in conditioned media of cultured FLS in a time-dependent manner up to 48 h. Immunohistochemistry showed a strong positive staining for COX-2 in the lining and sub-lining synovial tissues of the TMJ of IL-1beta-injected rats. In contrast, staining for COX-1 was the same in synovial tissues with and without IL-1beta injection. CONCLUSION: These data suggest that COX-2 expression stimulated by IL-1beta stimulates the production of PGE(2) in FLS and plays important roles in the progression of inflammation in TMJ.


Subject(s)
Cyclooxygenase 2/metabolism , Synovial Membrane/metabolism , Synovitis/metabolism , Temporomandibular Joint Disorders/metabolism , Temporomandibular Joint/metabolism , Adult , Animals , Cells, Cultured , Cyclooxygenase 1/genetics , Cyclooxygenase 1/metabolism , Cyclooxygenase 2/genetics , Disease Models, Animal , Female , Fibroblasts/cytology , Fibroblasts/immunology , Fibroblasts/metabolism , Gene Expression Profiling , Gene Expression Regulation/immunology , Humans , Immunohistochemistry , Interleukin-1beta/metabolism , Male , Oligonucleotide Array Sequence Analysis , RNA/analysis , Rats , Synovial Membrane/cytology , Synovial Membrane/immunology , Synovitis/immunology , Synovitis/pathology , Temporomandibular Joint/cytology , Temporomandibular Joint/immunology , Temporomandibular Joint Disorders/immunology , Temporomandibular Joint Disorders/pathology , Young Adult
11.
J Hum Genet ; 52(4): 370-373, 2007.
Article in English | MEDLINE | ID: mdl-17264970

ABSTRACT

We report the case of a 12 year-old boy with oto-palato-digital syndrome type II (OPD II). He had various anomalies at birth, including bilateral cataracts, bilateral glaucoma, bilateral severe hearing impairment, congenital heart defect, umbilical herniation, bowed extremities and constrictions of various joints. These clinical features and whole body X-ray findings were compatible with OPD II. However, his ocular disorders such as congenital cataract and glaucoma, and congenital heart defect have never been associated with OPD II as far as we know. His chromosomal analysis revealed normal karyotype, 46,XY. Analysis of the filamin A gene using a standard PCR-direct sequencing method determined a C586T (Arg196Trp) missense mutation in exon 3. Interestingly, the same C586T mutation was reported previously in a patient with OPD I (mild form). Thus, phenotype-genotype correlation of OPD is lacking in those patients. Further clinical and genetic studies are needed to clarify the relationship between phenotypes and genotypes, or to identify other factor(s) that influence the clinical features of this syndrome.


Subject(s)
Abnormalities, Multiple/genetics , Contractile Proteins/genetics , Fingers/abnormalities , Hearing Loss, Bilateral/genetics , Microfilament Proteins/genetics , Palate/abnormalities , Child , Filamins , Genotype , Humans , Karyotyping , Male , Mutation, Missense , Phenotype , Syndrome
12.
Int Arch Occup Environ Health ; 79(7): 545-9, 2006 Aug.
Article in English | MEDLINE | ID: mdl-16404638

ABSTRACT

OBJECTIVE: Humans are exposed to various carcinogens by smoking. Urinary metabolites of polycyclic aromatic hydrocarbons (PAH), one of the major carcinogens in cigarette smoke, were measured as the environmental carcinogen exposure marker for humans. We evaluated urinary exposure markers for smoking cessation. METHOD: In this study, we measured cigarette smoke exposure markers, such as urinary cotinine, PAH exposure markers, such as urinary 1-hydroxypyrene (1-OHP), 2-naphthol (2-NP) and 1-naphthol (1-NP), as well as a methylating chemical exposure marker, 7-methylguanine (7-MeG). The before smoking cessation levels of these markers, and the after smoking cessation levels were then compared. Eighteen subjects participated in this smoking cessation program. RESULTS: Levels of all of four markers were found to have decreased by 19-54% after smoking cessation. Urinary cotinine, 1-OHP, 2-NP and 7-MeG levels were found to have significantly decreased after smoking cessation. There were positive correlations between cotinine and three urinary PAH markers and between 1-OHP, 2-NP and 7-MeG. CONCLUSION: PAH metabolites were better biomarkers of smoking cessation than 7-MeG. Analyzing urinary metabolites or urinary DNA adducts is suitable for epidemiological studies.


Subject(s)
Guanine/analogs & derivatives , Polycyclic Aromatic Hydrocarbons/analysis , Polycyclic Aromatic Hydrocarbons/urine , Smoking Cessation , Adult , Guanine/analysis , Guanine/urine , Humans , Japan , Middle Aged
13.
Int J Oral Maxillofac Surg ; 34(7): 727-32, 2005 Oct.
Article in English | MEDLINE | ID: mdl-15982854

ABSTRACT

The aim of this study was to investigate the changes in the state of arthroscopically observed fibrous adhesions (FA) after visually guided irrigation (VGIR) and the influence of FA on clinical outcome in patients with chronic closed lock of the temporomandibular joint (TMJ). Forty-eight TMJs of 48 patients with unilateral chronic closed lock were enrolled in this study. All 48 joints underwent VGIR twice. After the first VGIR (immediately before the second VGIR), clinical outcome was assessed as regards maximal interincisal opening (MIO) and self-evaluated TMJ pain (VAS). Thirty patients were symptom-free (good outcome group) and the remaining 18 patients had symptoms (poor outcome group). In each group, the changes of the MIO, VAS and severity of FA (FA score) after the first VGIR were studied. The influence of FA score in the first and second VGIR on clinical outcome was analyzed by logistic regression analysis. There was no joint with disappearance or reduction of FA after the first VGIR. In both groups, MIO and VAS were significantly improved after the first VGIR even though the state of FA became significantly worse. The multivariate logistic regression analysis showed that the risk of poor outcome for FA scores in the first and second VGIR were 0.89-times (95% CI: 0.33-2.40, P=0.82) and 1.76-times (95% CI: 0.54-5.73, P=0.35), respectively. The dose-response relationships between FA scores in the first or second VGIR were not significant. In conclusion, our results indicate that the presence of FA or a postoperative worsening of FA (including postoperative new FA formation) seems not to affect the clinical outcome as regards MIO and VAS in patients with chronic closed lock of the TMJ.


Subject(s)
Temporomandibular Joint Disorders/pathology , Temporomandibular Joint Disorders/surgery , Adult , Aged , Arthroscopy , Chronic Disease , Facial Pain/surgery , Female , Humans , Joint Dislocations/surgery , Logistic Models , Male , Middle Aged , Odds Ratio , Pain Measurement , Therapeutic Irrigation , Tissue Adhesions/pathology , Treatment Outcome
14.
J Oral Pathol Med ; 33(10): 629-33, 2004 Nov.
Article in English | MEDLINE | ID: mdl-15482330

ABSTRACT

BACKGROUND: Synovial fibroblasts of temporomandibular joint (TMJ) are poorly characterized, although they have important roles in progression of temporomandibular disorders (TMD). In this study, we investigated responses of synovial fibroblasts to interleukin (IL)-1beta. METHODS: We examined gene expression profiles of synovial fibroblasts in response to IL-1beta, using Affymetrix GeneChip. Regulated upon activation normal T-cell expressed and secreted (RANTES) gene expression was confirmed by polymerase chain reaction (PCR) and real-time PCR. RANTES protein levels were measured by enzyme-linked immunosorbent assay (ELISA). RESULTS: The RANTES was preferentially up-regulated in synovial fibroblasts by IL-1beta. The increase in RANTES gene expression in response to IL-1beta was confirmed by PCR and real-time PCR. Protein level of RANTES in synovial fibroblasts was also increased by IL-1beta. CONCLUSIONS: The RANTES, a cc-type chemokine, has chemotactic effects on lymphocytes and monocytes. Increased gene expression and protein production of RANTES in synovial fibroblasts, in response to IL-1beta, may play an important role in recruitment of inflammatory cells into synovium and progression of synovitis in TMD.


Subject(s)
Chemokine CCL5/biosynthesis , Gene Expression/drug effects , Interleukin-1/pharmacology , Synovial Membrane/cytology , Synovial Membrane/metabolism , Temporomandibular Joint/metabolism , Adolescent , Adult , Chemokine CCL5/genetics , Enzyme-Linked Immunosorbent Assay , Female , Fibroblasts/metabolism , Gene Expression Profiling , Humans , Oligonucleotide Array Sequence Analysis , Polymerase Chain Reaction/methods , RNA, Messenger/analysis , Temporomandibular Joint/cytology , Up-Regulation
17.
Acta Neurochir Suppl ; 86: 559-63, 2003.
Article in English | MEDLINE | ID: mdl-14753506

ABSTRACT

Hyperosmotic opening of the blood-brain barrier (BBB) by mannitol is being used to enhance drug transport in human brains. Recently, cooling of the solution has been reported to have potential to open the BBB. However, the mechanism in barrier opening and closure remains elusive. We studied the rapid changes in cerebrovascular permeability after hyperosmotic and hypothermic BBB opening in rats, and then demonstrated that the Na+/Ca++ exchange blocker (KB-R7943) prolongs opening. BBB opening was attained by using intra-arterial infusion of hyperosmotic mannitol (1.6 M) and 1.1 M mannitol (which is less hyperosmotic than commonly used mannitol) at 4 degrees in Sprague-Dawley (SD) rats. To measure the changes in cerebrovascular permeability, perfusate-containing [14C]-sucrose was infused intra-arterially at different time points following hyperosmotic and hypothermic stress. Cerebrovascular permeability was then measured with the in situ brain perfusion technique. 1.6 M Mannitol produced opening of the BBB but the duration of the opening was less than 30 minutes. Use of 1.1 M Mannitol at 4 degrees indicated the same results. We then investigated the effect of a Na/Ca ion exchange blocker (KB-R7943) in both hyperosmotic and hypothermic BBB opening. KB-R7943 extended BBB opening up to 30 min without affecting the peak level of BBB permeability at 5 minutes. Our findings represent important experimental information regarding pharmacological manipulation of BBB opening. The possibility of prolonging the transient opening of the BBB has major clinical implications.


Subject(s)
Blood-Brain Barrier/drug effects , Hypothermia, Induced , Mannitol/pharmacology , Thiourea/analogs & derivatives , Animals , Capillary Permeability/drug effects , Dose-Response Relationship, Drug , Male , Mannitol/administration & dosage , Osmolar Concentration , Osmosis , Rats , Rats, Sprague-Dawley , Sodium-Calcium Exchanger/antagonists & inhibitors , Thiourea/pharmacology , Time Factors
18.
Int J Oral Maxillofac Surg ; 31(5): 489-94, 2002 Oct.
Article in English | MEDLINE | ID: mdl-12418563

ABSTRACT

This study examined the characteristics and outcome of patients undergoing partial inferior turbinectomy during secondary alveolar bone grafting. Thirty-three of 55 patients with cleft lip and palate or cleft lip and alveolus who underwent secondary alveolar bone grafting concurrently received partial inferior turbinectomy to ensure that the height of the nasal floor was similar on the cleft side and non-affected side. At the time of surgery, patients who underwent turbinectomy were significantly older than those who did not undergo the procedure. The proportion of patients who underwent turbinectomy was significantly higher among patients with cleft lip and palate than among those with cleft lip and alveolus. These differences apparently reflected the developmental stage of the inferior turbinate and the relative severity of alveolar and palatal defects. In most patients who underwent partial inferior turbinectomy, postoperative X-ray films revealed excellent bone formation at the graft site. Our findings suggest that partial inferior turbinectomy during secondary alveolar bone grafting is a very useful procedure that facilitates dissection to the height of the nasal floor, reconstruction of the mucosal nasal floor, and formation of a sufficient bone bridge. It also promotes alveolar cleft closure, especially in patients with wide bone defects.


Subject(s)
Alveoloplasty/methods , Bone Transplantation/methods , Cleft Lip/surgery , Cleft Palate/surgery , Turbinates/surgery , Adolescent , Adult , Age Factors , Alveolar Process/abnormalities , Bone Transplantation/diagnostic imaging , Bone Transplantation/physiology , Child , Cleft Lip/diagnostic imaging , Cleft Palate/diagnostic imaging , Female , Follow-Up Studies , Humans , Male , Nasal Cavity/diagnostic imaging , Nasal Cavity/surgery , Nasal Mucosa/surgery , Osteogenesis/physiology , Osteotomy/methods , Radiography , Statistics as Topic , Statistics, Nonparametric , Treatment Outcome
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