[Relationship between the results of the treatment of patients with cerebral artery atherosclerosis and technology of carotid endarterectomy]. / Zavisimost' rezul'tatov lecheniia bol'nykh s aterosklerozom arterii golovnogo mozga ot tekhnologii karotidnoi éndarteréktomii.

Presented herein is an analysis of surgical treatment of 232 patients with atherosclerotic stenoses and occlusions of the carotid arteries, including 144 persons with bilateral lesions. The patients underwent carotid endarterectomy according to the traditional and eversion techniques. Analysis of the short- and long-term results has demonstrated that they do not depend on the technique of endarterectomy. The risk of carotid endarterectomy rises in occlusions of the contralateral internal carotid artery. The measures for this risk minimization are offered. The long-term results of surgical treatment of asymptomatic stenoses are better as compared to the results of drug therapy. Surgical treatment of atherosclerotic lesions followed by the treatment of lipid metabolism disorders provides for the improvement of the quality of life due to the restoration of work fitness, physical and social activity.

[An assessment of the efficacy of intravenous monotherapy with the preparation solcoseryl in patients with arteriosclerosis obliterans of the vessels of the lower extremities]. / Otsenka éffektivnosti vnutrivennoi monoterapii preparatom "Solkoseril" u bol'nykh s obliteriruiushchim aterosklerozom sosudov nizhnikh konechnostei.

The authors share their experiences with using Solcoseryl in treatment of 158 patients with obliterating atherosclerosis of the lower extremity vessels. This treatment was found to be very effective. A scheme of the treatment is proposed after which the improved quality of life retains during not less than 6 months in 93% of the patients. The accessory maintenance therapy with minimum doses of aspirin and nicotinic acid is enough between the courses of treatment with Solcoseryl.

[The efficacy of antithrombotic therapy after total obliteration-reversing therapy in atherosclerotic arterial occlusion of the lower extremities]. / Effektivnost' antitromboticheskoi terapii posle total'noi dezobliterapii pri ateroskleroticheskoi okkliuzii arterii nizhnikh konechnostei.

The operation of total desobliteration of the arteries (TDA) is a modification of semi-open eversive endarterectomy (EAE). Under study was frequency of thromboses of the desobliteration area, its correlation with postoperative changes of the state of hemorheology and hemocoagulation and the antithrombotic treatment of 150 patients who were operated upon for total desobliteration of the iliofemoral-popliteal segment. The patients were divided into 2 groups which had no substantial difference. At the postoperative period patients of the 1st group (79) were treated with Ticlid ("Sanofi" France) in dosage of 500 mg/day. Treatment of 71 patients of the second group included a combination of two medicines (A + D): aspirin--1000 mg/day and dipiridamol--150 mg/day. A comparative analysis of frequency of the development of cardio-vascular complications at the remote period has shown that in the first group of patients the frequency of development of acute myocardial infarction and acute disturbance of cerebral blood circulation was two times less than in the second group of patients. It is to be noted that in case of the developed in time occlusion in the operation area, the extremity was saved in the Ticlid group in 62% of cases (7 amputations per 18 cases of reocclusion) while in the (A + D) group the extremity was saved in 29% (17 amputations per 24 cases of thrombosis). Thus, the investigation of long-term results of TDA in combination with postoperative antithrombotic therapy of patients with atherosclerotic occlusions of the iliofemoral-popliteal segment arteries has shown high effectiveness of Ticlid. As compared with traditional methods of treatment with aspirin and dipiridamol treatment with Ticlid allowed the cases of restenosis and reocclusions to become more than two times less often.

[Study of the process of inactivating oleandomycin phosphate preparations]. / Izuchenie protsessa inaktivatsii preparatov oleandomitsina fosfata.

Ageing of oleandomycin preparations was studied. Certain biologically inactive components accumulating on storage of the preparations were isolated and investigated. A scheme for ageing of oleandomycin phosphate preparations is described. The scheme includes cleaving up of the water molecule at C11 and cleaving by the epoxide ring at the early stages and hydrolysis by the glycoside bonds at the later stages.

[Mass-spectrometric determination of specificity of proteinases]. / Mass-spektrometricheskoe opredelenie spetsifichnosti proteinaz.

Analysis of methods of the proteinase substrate specificity determination revealed that Michaelis constants found from the rates of hydrolysis of small synthetic substrates cannot be a good measure of selectivity, especially for proteinases of broad specificity used for hydrolysis of substrates of high molecular mass with multiple cleavage sites. Mass-spectrometric studies (ERIAD) of the hydrolysis of the insulin B chain with trypsin, chymotrypsin, and proteinase I showed that monitoring of the reaction mixtures by means of this technique gives more reliable information on the selectivity of proteinase towards high-molecular substrates.