1.
Eksp Klin Farmakol
; 56(1): 22-4, 1993.
Article
in Russian
| MEDLINE
| ID: mdl-8100727
ABSTRACT
The effects of some antiallergic drugs on H1-histamine, 5-HT2-serotonin, and M-cholinoreceptors ligand binding in the rat brain were studied in vitro. Dimedrol, dimebon, and phencarol bonded to H1-receptors: IC50 were 76 +/- 10, 153 +/- 15, 320 +/- 60 nM, respectively. Diazoline and dimebon had some affinity for 5-HT2-receptors, its IC50 was 880 +/- 90 nM. Dimedrol, phencarol and diazoline were found to be active against M-cholinoceptors, but when given in the maximal concentration (10 microM) it acted nonspecifically. In contrast to the other drugs, bicarphen had no effects on the binding of [3H]-mepyramine, [3H]-ketanserine, and [3H]-quinuclidinyl benzylate in the rat brain.
Subject(s)
Brain/drug effects , Histamine H1 Antagonists/pharmacology , Histamine H2 Antagonists/pharmacology , Ketanserin/pharmacokinetics , Pyrilamine/pharmacokinetics , Quinuclidinyl Benzilate/pharmacokinetics , Animals , Brain/metabolism , Drug Interactions , Ligands , Male , Rats , Rats, Sprague-Dawley , Receptors, Histamine H1/drug effects , Receptors, Histamine H1/metabolism , Receptors, Histamine H2/drug effects , Receptors, Histamine H2/metabolism , Receptors, Muscarinic/drug effects , Receptors, Muscarinic/metabolism , Tritium
2.
Biull Eksp Biol Med
; 72(12): 81-3, 1971 Dec.
Article
in Russian
| MEDLINE
| ID: mdl-5132143