ABSTRACT
Erectile dysfunction is a common pathology in the general population. The frequency of these erectile disorders is increased in some particular populations such as patients with renal impairment in which it is estimated between 50% and 70% depending on the stage of renal failure. AIMS: Our study aims to study erectile dysfunction in chronic hemodialyzed male patients. METHOD: This is a descriptive prospective study carried out during the period from April 3 to August 31, 2017 having covered 65 chronic hemodialyzed patients for more than 12 months. RESULT: In our study the prevalence of DE was 70.8% and moderate in 13.8%, severe in 30.8%, mild in 26.2%. Testosteronemia was normal in 83.1% of cases and significantly lower in patients with sexual disorders p = 0.030. Libido disorders were observed in 57% of our patients and significantly related to a decrease in testosteronemia p = 0.001. Vascular nephropathy was the most common etiology, i.e. 50.8% of cases followed by chronic Glomerulonephritis 24.6% and in 13.8% of cases no underlying etiology was found.
la dysfonction érectile est une affection fréquente dans la population générale. La fréquence de ces troubles de l'érection est majorée dans certaines populations particulières comme les patients insuffisants rénaux chez qui elle est estimée entre 50% à 70% selon le stade de l'insuffisance rénale. BUT: Notre étude a pour objectif d'évaluer la prévalence la dysfonction érectile chez les patients hémodialysés chroniques de sexe masculin. MÉTHODE: Il s'agit d'une étude prospective descriptive réalisée durant la période du 3 Avril au31 Aout 2017 ayant porté sur 65 patients hémodialysés chroniques depuis plus de 12 mois. RÉSULTAT: Dans notre étude la prévalence de la dysfonction érectile était de 70,8 %. Elle est modérée dans 13,8 %, sévère dans 30,8 %, et légère dans 26,2%. La testosteronémie était normale dans 83,1 % des cas et significativement plus basse chez les patients présentant des troubles sexuels p = 0,030. Les troubles de la libido étaient observés chez 57 % de nos patients et significativement liés à une diminution de la testostéronémie p = 0,001. La néphropathie vasculaire était l'étiologie la plus fréquente soit 50,8 % des cas puis la glomérulonéphrite chronique 24,6% et dans 13,8 % des cas aucune étiologie sous-jacente n'a été trouvée.
ABSTRACT
The growing range of drug resistant parasitic nematode populations threatens the sustainability of ruminant farming worldwide. In this context, nutraceuticals, animal feed that provides necessary dietary requirements while ensuring parasite control, could contribute to increase farming sustainability in developed and low resource settings. In this study, we evaluated the anthelmintic potential of lupin seed extracts against the major ruminant trichostrongylids, Haemonchus contortus and Teladorsagia circumcincta. In vitro observations showed that seed extracts from commercially available lupin varieties could significantly but moderately inhibit larval migration. This anthelmintic effect was mediated by the seed alkaloid content and was potent against both fully susceptible and multidrug resistant H. contortus isolates as well as a susceptible T. circumcincta isolate. Analytical chemistry revealed a set of four lupanine and sparteine-derivatives with anthelmintic activity, and electrophysiology assays on recombinant nematode acetylcholine receptors suggested an antagonistic mode of action for lupin alkaloids. An in vivo trial in H. contortus infected lupin-fed ewes and goats failed to demonstrate any direct anthelmintic effect of crude lupin seeds but infected lupin-fed goats suffered significantly less parasite-mediated blood losses. Altogether, our findings suggest that the anthelmintic potential of lupin remains limited. However, the potent alkaloids identified could lead to the development of novel drugs or may be used in combination with current anthelmintics to improve their efficacy.
Subject(s)
Alkaloids/analysis , Anthelmintics/pharmacology , Lupinus/embryology , Plant Extracts/pharmacology , Seeds/chemistry , Animals , Nematoda/drug effects , Plant Extracts/chemistryABSTRACT
In Mali, malaria is a major public health problem. The region of Sikasso is classified according to the geo-climatic facies as a zone with a long seasonal transmission of malaria greater than 6 months. OBJECTIVE: To describe the epidemiological, clinical and therapeutic characteristics of children aged 0- 5 years hospitalized for severe malaria in the pediatric ward of the Sikasso hospital. Variables analyzed were epidemiological, clinical, paraclinical, therapeutic and evolutionary. PATIENTS AND METHODS: This is a retrospective, 12-month (January-December 2014) cross-sectional study of all 0-5-year-olds hospitalized for severe malaria at the Sikasso Regional Hospital. RESULTS: The hospital frequency of severe malaria was 55.82%. The age group of 12-35 months was the most concerned (45.3%). The peak frequency was in August (21.2%). Anemic, mixed (anemia and neurological) and neurological forms were the most frequent. Artemether and quinine were the antimalarials used. The use of a blood transfusion was frequent (82.8%). The lethality was 10% and the mixed form (anemia and neurology) was the most lethal ((P<10-6). CONCLUSION: Malaria remains a national concern in Mali. Improving the quality of care and prevention must be a priority to reduce the lethality that remains high.
Au Mali, le paludisme constitue un problème majeur de santé publique. La région de Sikasso est classée selon le faciès géo climatique comme étant une zone à transmission saisonnière longue du paludisme supérieure à 6 mois. OBJECTIF: Décrire les caractéristiques épidémiologiques, et cliniques des enfants âgés de 0 à 5 ans hospitalisés pour paludisme grave au service de pédiatrie de l'hôpital de Sikasso. PATIENTS ET MÉTHODS: Il s'agit d'une étude transversale rétrospective sur douze mois (janvier-décembre 2014) de tous les enfants âgés de 0-5 ans hospitalisés pour paludisme grave à l'hôpital régional de Sikasso. Les variables analysées étaient épidémiologiques, cliniques, paracliniques, thérapeutiques et évolutifs. RÉSULTATS: La fréquence hospitalière du paludisme grave a été de 55,82%.La tranche d'âge de 12-35 mois a été la plus concernée (45,3%). Le pic de fréquence des cas a été atteint au mois d'aout (21,2%). Les formesanémique, mixte (anémie et neurologique) etneurologique ont été les plus fréquentes. L'artéméther et la quinine ont été les antipaludiques utilisés. Le recours à une transfusion sanguine a été fréquente (82,8%).La létalité est de10% et la forme mixte (anémie et neurologique) a été la plus létale ((P<10−6). CONCLUSION: Le paludisme reste une préoccupation nationale au Mali. L'amélioration de la qualité de la prise en charge et la prévention doivent êtreune priorité pour diminuer la létalité qui reste élevée.
ABSTRACT
BACKGROUND: A 4-item-questionnaire has been developed by the "Netzwerk gegen Darmkrebs e. V." (Network against colorectal cancer) to identify familial or hereditary susceptibility to colorectal cancer. The aim of this inquiry was to validate the questionnaire in 40 to 54 year old persons in a general practice setting. METHODS: Four general practices from the "Forschungsnetzwerk Allgemeinmedizin Frankfurt" database generated a sample of 100 index patients whose first-degree relatives were known to the general practitioner. The general practitioners prepared pedigrees in accordance with the four items of the questionnaire. Subsequently, the index patients were surveyed by a healthcare assistant on the basis of the questionnaire. The level of agreement between the patients' and general practitioners' responses was measured using Cohen's kappa coefficient. RESULTS: An almost perfect level of agreement was found for question 1 on whether a first-degree relative had been diagnosed with colorectal cancer (kappa coefficient 0,82; CI: 0,58-1,10). Question 2 on the existence of a first-degree relative under the age of 50 diagnosed with colorectal cancer was not answered positively by general practitioners for any patient, whereas one patient answered the question positively. Interpreting the level of agreement using the kappa coefficient was meaningless in this case. General practitioners did not have information to answer question 3 on the occurrence of a colorectal polyp in a first-degree relative under the age of 50. Likewise, it was impossible to find the necessary information on second-degree relatives in practice files (question 4). Overall, 18,8% of all patients (15/80) answered "yes" to one or more questions on the existence of a hereditary colorectal cancer risk. CONCLUSION: Question 1 allows the identification of a familial colorectal cancer risk among 40 to 54 year old persons in a general practice setting. Questions 2 to 4 of the questionnaire could not be validated using the chosen methodology. However, the valid answer of 40 to 54 year old persons to question 1 allows familial risk to be identified. More detailed family history-taking regarding hereditary risk should be conducted in this group.
Subject(s)
Colorectal Neoplasms , General Practice , Genetic Predisposition to Disease , Adult , Colorectal Neoplasms/genetics , Family Practice , Germany , Humans , Middle Aged , Surveys and QuestionnairesABSTRACT
Cancer is a complex disease requiring the involvement of several health care providers. A possible constant in the cancer care process is the general practitioner (GP). The aim of this project was to evaluate GPs' satisfaction with cooperation with other health care providers in the cancer care process of their patients and to explore which variables are associated with higher satisfaction with cooperation with other health care providers. We considered the following health care providers: outpatient oncology specialists, physicians in relatively small hospitals (≤400 beds), physicians in relatively large hospitals (>400 beds), home care services, outpatient psycho(onco)logists/psychotherapists, hospice/palliative care units and specialised palliative home care. The cross-sectional study was carried out as a postal survey all over Germany. Data were analysed descriptively and by means of logistic regression. Overall satisfaction with cooperation with other health care providers involved in cancer care was rather high. Only cooperation with outpatient psycho(onco)logists/psychotherapists was rated as not assessable/irrelevant by a majority of GPs. For all other health care providers under review, both communication and the transfer of sufficient information in good time were associated with overall satisfaction with cooperation. Little association was found between GP and practice variables and overall satisfaction with cooperation with the considered health care providers.
Subject(s)
Attitude of Health Personnel , Cooperative Behavior , General Practitioners , Neoplasms/therapy , Cross-Sectional Studies , Female , Germany , Health Personnel , Home Care Services , Hospice Care , Humans , Logistic Models , Male , Oncologists , Palliative Care , Personal Satisfaction , Psycho-Oncology , Surveys and QuestionnairesABSTRACT
UNLABELLED: The objective of this work was to determine epidemio-clinical and therapeutic aspects of foot bones fractures in Orthopedic and Traumatology service of Gabriel TOURE hospital. PATIENT AND METHODS: The study was retrospective descriptive and carried on 454 patients of January 1996 to December 2005. Have been included the patients admitted and tidy in the service during the period of survey, that had fractures isolated of the foot or associated to other fractures. Have not been included the patients with fractures of the foot that interrupted their treatment in the hospital for no conventional treatment. RESULTS: The masculine sex was predominant (321 men, 133 women, sex-ratio 2.41). The age groups of 21-30 years and 31-40 were the more attacks with respectively 32.38% and 20.48% (Table I). The workers were the more reached with 28.41% (Table II). On the ten years, 2001 recorded the biggest number of case of foot fracture with 12.56% (Table III). The accidents of the public way and the accidents of work were the most frequent etiology with respectively 70.48% and 20.71%. The right foot was the more frequently broken with 55.95%. The metatarsus was the more reached with 50%. Fractures closed of the foot represented 88.33%, the open fractures 11.67%. The treatment of the closed fractures was exclusively orthopedic. In the cases of open fractures the surgical dressing has been done follow-up of the orthopedic contention. The recovery has been gotten in 60.79% of the cases. The complications were of 39.21% among which the vicious calluses predominated with 34.83% (Table IV). The result of the treatment was good in 73.57% of the cases, means in 17.62% of the cases and bad in 8.81% of the cases. CONCLUSION: The fractures of the foot concerned more the men and the working profession. So the most active layer of the society was the more exposed to the accidents of the public way and the work. The osteosynthesis in the complex or complicated shapes could have improved our results.
Subject(s)
Foot Bones/injuries , Fractures, Bone , Adolescent , Adult , Child , Child, Preschool , Female , Fractures, Bone/diagnosis , Fractures, Bone/epidemiology , Fractures, Bone/therapy , Humans , Male , Retrospective Studies , Young AdultABSTRACT
L'objectif de ce travail etait de determiner les aspects epidemio-cliniques et therapeutiques des fractures des os du pied dans le service d'Orthopedie et de Traumato- logie de l'Hopital Gabriel Toure. Patients et Methodes : Il s'agit d'une etude retrospective descriptive portant sur 454 patients dans une periode allant de janvier 1996 a decembre 2005. Ont ete inclus les patients admis et soignes dans le service pendant la periode d'etude; qui avaient des fractures isolees du pied ou associees a d'autres fractures. N'ont pas ete inclus les patients avec des fractures du pied qui ont interrompu leur traitement hospitalier pour un traitement non conventionnel. Resultats : Le sexe masculin etait predominant (321 hommes; 133 femmes; sex-ratio 2;41). Les tranches d'age de 21-30 ans et de 31-40 ont ete les plus atteintes avec respectivement 32;38et 20;48(Tableau I). Les ouvriers etaient les plus atteints avec 28;41(Tableau II). Sur les dix ans; 2001 a enregistre le plus grand nombre de cas de fracture de pied avec 12;56(Tableau III). Les accidents de la voie publique et les accidents de travail ont ete les etiologies les plus frequentes avec respectivement 70;48et 20;71. Le pied droit a ete le plus frequemment fracture avec 55;95. Le metatarse a ete le plus atteint avec 50. Les fractures fermees du pied representaient 88;33; les ouvertes 11;67. Le traitement des fractures fermees a ete exclusivement orthopedique. Dans les cas de fractures ouvertes le parage chirurgical a ete effectue suivi de la contention orthopedique. La guerison a ete obtenue dans 60;79des cas. Les complications ont ete de 39;21parmi lesquelles les cals vicieux ont predomine avec 34;83(Tableau IV). Le resultat du traitement a ete bon dans 73;57des cas; moyen dans 17;62des cas et mauvais dans 8;81des cas. Conclusion : Les fractures du pied ont concerne plus les hommes et la profession ouvriere. Ainsi la couche la plus active de la societe a ete la plus exposee aux accidents de la voie publique et de travail. L'osteosynthese dans les formes complexes ou compliquees aurait pu ameliorer le pourcentage de nos resultats
Subject(s)
Fractures, Bone , Fractures, Bone/epidemiology , Fractures, Closed , Fractures, OpenSubject(s)
Behcet Syndrome/genetics , Behcet Syndrome/pathology , Child , Child, Preschool , Female , Humans , InfantABSTRACT
We report the cases of 38 children with transfusion-associated HIV infection: 18 hemophiliacs and 2 patients with Von Willebrand disease, 6 with hemoglobinopathies, 8 with malignant diseases or aplastic anemia, 2 transfused during neonatal period and 2 during a surgical operation. Two groups with a different prognosis were found: In group A [hemophilia and Von Willebrand disease (n = 20)] 17 patients were asymptomatic or only with lymphadenopathy; 3 reached stage IV and none died. In group B [Others (n = 14)] 2 patients were asymptomatic, 4 reached stage IV and 8 died, 4 of them directly from AIDS. The difference between both groups was statistically significant. Prognosis of HIV infection is particularly severe in patients with leukemia, malignant tumors and aplastic anemia.
