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1.
Klin Med (Mosk) ; 92(10): 26-32, 2014.
Article in Russian | MEDLINE | ID: mdl-25782318

ABSTRACT

It was shown that parameters of metabolic syndrome as predictors of lethal vascular outcomes of arterial hypertension (AH) in Belarus are significantly different fiom those proposed in WHO recommendations (1999). The glucose level of informative value in WHO recommendations is 6.1 mmol/l versus 5.6 mmol/l in Belarus, total cholesterol 5.0 and 5.9 mmol/l respectively. A more detailed verification of the value of both parameters is needed for the patients in Belarus and Russia depending on age and sex using non-linear models. We used a comprehensive approach to prognosis of the risk of vascular lethal outcomes of AH as a component of metabolic syndrome with the evaluation of results of clinical and laboratory examination as well as orthostatic reactions in patients of different age groups. Construction of the prognostic algorithm "Classification tree" taking account of orthostatic reactions enhances the correctness of lethal outcome prognosis up to 81.8%. The study revealed the prognostic value of systolic and diastolic arterial pressure in the supine position (15 min of active aortostatic sample) for prognostication of vascular lethal outcomes. Further studies are needed on the role of orthostatic reactions in AH patients of old age together with clinical and laboratory parameters in the prognostication of outcomes of various cardiovascular diseases.


Subject(s)
Acute Coronary Syndrome , Hypertension , Hypotension, Orthostatic , Metabolic Syndrome/physiopathology , Stroke , Acute Coronary Syndrome/epidemiology , Acute Coronary Syndrome/etiology , Aged , Blood Glucose/analysis , Cholesterol/blood , Female , Humans , Hypertension/complications , Hypertension/diagnosis , Hypertension/metabolism , Hypertension/physiopathology , Hypotension, Orthostatic/diagnosis , Hypotension, Orthostatic/etiology , Hypotension, Orthostatic/metabolism , Hypotension, Orthostatic/physiopathology , Kaplan-Meier Estimate , Male , Middle Aged , Prognosis , Proportional Hazards Models , Republic of Belarus/epidemiology , Risk Assessment , Risk Factors , Russia/epidemiology , Stroke/epidemiology , Stroke/etiology , Urea/blood
2.
Klin Lab Diagn ; (1): 8-11, 2005 Jan.
Article in Russian | MEDLINE | ID: mdl-15765644

ABSTRACT

Differences in the reaction of the fat-acid spectrum of high-density lipoproteins (HDLP and HDLP3) and ethers of transfer-protein cholesterol (ETPC) as well as in the activity of lecithin cholesterin acetyltransferase and the content of cholesterol were compared for male and female patients (of the second mature age) with appendicitis. It was concluded that the female patients with appendicitis had, versus healthy women of the same age, a lower share of poly-unsaturated fat acids (PUFA) in the HDLP content and, possibly, a compensatorily intensified activity of the delta9-desaturase system; the changes were concomitant with a reduced functional HDLP activity. Within the discussed age span, the female patients with appendicitis had, versus the male patients, a more drastically reduced content of PUFA in HDLP, which was accompanied by a more intense modification of their functional activity with an active metabolism of PUFA (possibly of the omega9-row) due to ETPC.


Subject(s)
Appendicitis/blood , Fatty Acids, Unsaturated/blood , Lipoproteins, HDL/blood , Adult , Age Factors , Female , Humans , Male , Middle Aged , Sex Factors
3.
Vopr Med Khim ; 40(2): 24-8, 1994.
Article in Russian | MEDLINE | ID: mdl-8160423

ABSTRACT

A high-cholesterol diet containing 3.5% cholesterol, 0.2% methyl thiouracil and 20% of heated sunflower-seed oil caused an increase in the content of cholesterol, triacylglycerols, diene conjugates and in the activity of phospholipase A2 in rat liver and of serum total cholesterol and cholesterol of low density lipoproteins, and a decrease in the activity of hepatic cholesterol esterase, in the fractional activity of lecithin:cholesterol acetyl transferase (LCAT), in the activity of the enzymes involved in the lipolytic transformation of lipoproteins and in the serum levels of very low density lipoprotein cholesterol. The content of malonic dialdehyde in liver tissue and molar activity of LCAT in blood serum were increased after preirradiation (0.5 and 5.0 Gy) of rats kept on the cholesterol diet. The preparation of polyunsaturated phosphatidylcholine was shown to decrease the content of triacylglycerols and diene conjugates in liver tissue of rats with alimentary hypercholesterolemia. In rats irradiated in a dose of 0.5 Gy the phosphatidylcholine preparation decreased the content of cholesterol in liver tissue and blood serum, exhibited the normalizing effect on the content of cholesterol of high density lipoproteins, on the activity of superoxide dismutase and glutathione peroxidase; in a dose of 5.0 Gy this phosphatidylcholine preparation normalized the content of malonic dialdehyde, activity of the enzymes involved in lipolytic transformation of lipoproteins and increased the LCAT activity.


Subject(s)
Antioxidants , Fatty Acids, Unsaturated/pharmacology , Hypercholesterolemia/enzymology , Lipolysis , Phosphatidylcholines/pharmacology , Radiation Injuries, Experimental/enzymology , Animals , Cholesterol/blood , Cholesterol/metabolism , Dietary Fats/administration & dosage , Dietary Fats/pharmacology , Fatty Acids, Unsaturated/administration & dosage , Gamma Rays , Glutathione Peroxidase/metabolism , Hypercholesterolemia/complications , Liver/enzymology , Male , Malondialdehyde/metabolism , Phosphatidylcholines/administration & dosage , Radiation Injuries, Experimental/complications , Rats , Sterol O-Acyltransferase/metabolism , Superoxide Dismutase/metabolism
5.
Vopr Med Khim ; 36(5): 91-2, 1990.
Article in Russian | MEDLINE | ID: mdl-2251807

ABSTRACT

Methods of self-directed study of biochemistry by students are considered in connection with initial levels of their theoretical knowledge and laboratory experience. This type of training involved individual tasks and free discussion on the results obtained. Optimal results were observed in organization of self-directed work in small groups.


Subject(s)
Biochemistry/education , Education, Medical, Undergraduate , Programmed Instructions as Topic , Teaching/methods , USSR
6.
Article in Russian | MEDLINE | ID: mdl-2073530

ABSTRACT

The rate of cholesterin ether formation in blood serum during the periods of rapid recovery of liver mass decreases after partial hepatectomy in rats. This effect is connected with the changes in quantity and composition of lecithin cholesterin acyltransferase (LCAT) as well the kinetic characteristics of lipoprotein of high density. This ferment was isolated from blood serum and purified in 28,500 times at different periods of liver regeneration. A conclusion concerning the presence of reverse dependence between the pronounced regeneration processes in liver and LCAT activity at high level of nonetherificated cholesterin in substrate has been drawn. Some recommendations for LCAT activity reducing processes in liver are given.


Subject(s)
Liver Regeneration/physiology , Phosphatidylcholine-Sterol O-Acyltransferase/blood , Animals , Cholesterol/blood , Cholesterol Esters/blood , Hepatectomy , Male , Phospholipids/blood , Rats , Time Factors
7.
Vopr Med Khim ; 35(2): 37-42, 1989.
Article in Russian | MEDLINE | ID: mdl-2662600

ABSTRACT

Two-step regeneration of rat liver tissue was observed after partial hepatectomy. The first step involved mitosis of hepatocytes and the second step--division of the cells containing two nuclei and hypertrophy of hepatocytes. Both these steps of liver tissue regeneration were accompanied by hypercholesterolemia and a decrease in the cholesterol esterification activity in blood serum. The factors, stimulating hepatocyte proliferation, accelerated the reparative liver tissue regeneration due to activation of mitosis and the early division of the cells containing two nuclei. At the same time, the highest regeneration of the cholesterol esterification system was detected in circulation.


Subject(s)
Cholesterol Esters/blood , Liver Regeneration , Liver/cytology , Proteins/physiology , Animals , Cell Division , Hepatectomy , Interleukin-6 , Proteins/isolation & purification , Rats
10.
Vopr Med Khim ; 33(6): 124-8, 1987.
Article in Russian | MEDLINE | ID: mdl-3328413

ABSTRACT

Three phases of cholesterolemia were detected in rats after single administration of CCl4 at a dose of 0.3 ml of oil solution per 100 g of body mass. Factors, stimulating proliferation of hepatocytes and isolated from regenerating liver tissue, did not affect the type of cholesterolemia whereas they stimulated cholesterol esters formation in circulation.


Subject(s)
Carbon Tetrachloride Poisoning/blood , Chemical and Drug Induced Liver Injury/blood , Cholesterol Esters/blood , Proteins/physiology , Acute Disease , Animals , Cholesterol, HDL/blood , Interleukin-6 , Liver Regeneration , Male , Rats
11.
Article in Russian | MEDLINE | ID: mdl-3580417

ABSTRACT

The effect of proliferation stimulating factors (PSF) obtained from regenerating liver on the cholesterol esterification in blood serum under deep tetrachloromethane intoxication has been studied in experiments with white rats. Three phases in dynamics of cholesterol content in blood serum have been picked out after a single tetrachloromethane injection. The content of total cholesterol and cholesterol esters reduces during the first phase (24 h), during the second phase (3-7th day) it increases and during the third phase (15th day) these values become normal. PSF injection does not produce any influence on the nature of blood cholesterol under deep tetrachloromethane intoxication, but stimulates the processes of cholesterol ester formation in blood serum.


Subject(s)
Carbon Tetrachloride Poisoning/blood , Cholesterol Esters/blood , Cytoplasm/physiology , Liver Regeneration , Liver/drug effects , Proteins , Animals , Cholesterol/blood , Esterification , Hepatectomy , Lipoproteins, HDL/blood , Male , Molecular Weight , Rats , Time Factors
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