Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 4 de 4
Filter
Add more filters










Database
Language
Publication year range
1.
Sensors (Basel) ; 24(3)2024 Jan 25.
Article in English | MEDLINE | ID: mdl-38339497

ABSTRACT

As the operational status of aircraft engines evolves, their fault modes also undergo changes. In response to the operational degradation trend of aircraft engines, this paper proposes an aircraft engine fault diagnosis model based on 1DCNN-BiLSTM with CBAM. The model can be directly applied to raw monitoring data without the need for additional algorithms to extract fault degradation features. It fully leverages the advantages of 1DCNN in extracting local features along the spatial dimension and incorporates CBAM, a channel and spatial attention mechanism. CBAM could assign higher weights to features relevant to fault categories and make the model pay more attention to them. Subsequently, it utilizes BiLSTM to handle nonlinear time feature sequences and bidirectional contextual feature information. Finally, experimental validation is conducted on the publicly available CMAPSS dataset from NASA, categorizing fault modes into three types: faultless, HPC fault (the single fault), and HPC&Fan fault (the mixed fault). Comparative analysis with other models reveals that the proposed model has a higher classification accuracy, which is of practical significance in improving the reliability of aircraft engine operations and for Remaining Useful Life (RUL) prediction.

2.
Comput Intell Neurosci ; 2022: 4987639, 2022.
Article in English | MEDLINE | ID: mdl-35958779

ABSTRACT

Performance prediction based on candidates and screening based on predicted performance value are the core of product development. For example, the performance prediction and screening of equipment components and parts are an important guarantee for the reliability of equipment products. The prediction and screening of drug bioactivity value and performance are the keys to pharmaceutical product development. The main reasons for the failure of pharmaceutical discovery are the low bioactivity of the candidate compounds and the deficiencies in their efficacy and safety, which are related to the absorption, distribution, metabolism, excretion, and toxicity (ADMET) of the compounds. Therefore, it is very necessary to quickly and effectively perform systematic bioactivity value prediction and ADMET property evaluation for candidate compounds in the early stage of drug discovery. In this paper, a data-driven pharmaceutical products screening prediction model is proposed to screen drug candidates with higher bioactivity value and better ADMET properties. First, a quantitative prediction method for bioactivity value is proposed using the fusion regression of LGBM and neural network based on backpropagation (BP-NN). Then, the ADMET properties prediction method is proposed using XGBoost. According to the predicted bioactivity value and ADMET properties, the BVAP method is defined to screen the drug candidates. And the screening model is validated on the dataset of antagonized Erα active compounds, in which the mean square error (MSE) of fusion regression is 1.1496, the XGBoost prediction accuracy of ADMET properties are 94.0% for Caco-2, 95.7% for CYP3A4, 89.4% for HERG, 88.6% for hob, and 96.2% for Mn. Compared with the commonly used methods for ADMET properties such as SVM, RF, KNN, LDA, and NB, the XGBoost in this paper has the highest prediction accuracy and AUC value, which has better guiding significance and can help screen pharmaceutical product candidates with good bioactivity, pharmacokinetic properties, and safety.


Subject(s)
Drug Discovery , Caco-2 Cells , Humans , Pharmaceutical Preparations , Reproducibility of Results
3.
Sensors (Basel) ; 21(24)2021 Dec 13.
Article in English | MEDLINE | ID: mdl-34960417

ABSTRACT

Spare parts are one of the important components of the equipment comprehensive support system. Spare parts management plays a decisive role in achieving the desired availability with the minimum cost. With the equipment complexity increasing, the price of spare parts has risen sharply. The traditional spare parts management makes the contradiction between fund shortage and spare parts shortage increasingly prominent. Based on the analysis of the multi-echelon and multi-indenture spare parts support model VARI-METRIC (vary multi-echelon technology for recoverable item control, VARI-METRIC), which is widely used by troops and enterprises in various countries, the model is mainly used in high system availability scenarios. However, in the case of low equipment system availability, the accuracy and cost of model inventory prediction are not ideal. This paper proposed the multi-level spare parts optimization model, which is based on the demand-supply steady-state process. It is an analytical model, which is used to solve the low accuracy problem of the VARI-METRIC model in the low equipment system availability. The analytical model is based on the multi-level spare parts support process. The article deduces methods for solving demand rate, demand-supply rate, equipment system availability, and support system availability. The marginal analysis method is used in the model to analyze the spare parts inventory allocation strategy's current based cost and availability optimal value. Finally, a simulation model is established to evaluate and verify the model. Then, the simulation results show that, when the low availability of equipment systems are 0.4, 0.6, the relative errors of the analytical model are 3.54%, 3.86%, and its costs are 0.52, 1.795 million ¥ RMB. The experiment proves that the inventory prediction accuracy of the analytical model is significantly higher than that of the VARI-METRIC model in low equipment system availability. Finally, the conclusion and future research directions are discussed.


Subject(s)
Computer Simulation , Cost-Benefit Analysis
4.
ACS Appl Mater Interfaces ; 10(11): 9522-9531, 2018 Mar 21.
Article in English | MEDLINE | ID: mdl-29482318

ABSTRACT

Photochemical preparation of inexpensive hydrogen evolution cocatalysts is of great significance and is challenging. Currently, the crucial factors in the photochemical preparation of nonnoble metals are still unknown. In this work, taking Co/g-C3N4 composite photocatalysts as a case, complexing agents and sacrificial agents were found to be the crucial factors for the photochemical deposition process. Cobalt was supported on the electron outlet points of g-C3N4 for 1 h, and the ratio of Co in the Co/g-C3N4 composite photocatalyst can be regulated by changing the irradiation time of the preparation process. The optimized hydrogen evolution rate of Co/g-C3N4 was about 11.48 µmol h-1, which was 75 times more than pure g-C3N4. The photocatalytic H2 evolution rate was stable after 48 h. The mechanism for the high activity of Co/g-C3N4 composites was explored by surface photovoltage spectra and photoluminescence spectra. Co effectively promoted the separation of the photogenerated electrons and holes of g-C3N4 and improved the H2 production rate.

SELECTION OF CITATIONS
SEARCH DETAIL
...