ABSTRACT
More and more clinical trials have explored the role of liquid biopsy in the diagnosis and treatment of EGFR-mutated NSCLC. In certain circumstances, liquid biopsy has unique advantages and offers a new way to detect therapeutic targets, analyze drug resistance mechanisms in advanced patients, and monitor MRD in patients with operable NSCLC. Although its potential cannot be ignored, more evidence is needed to support the transition from the research stage to clinical application. We reviewed the latest progress in research on the efficacy and resistance mechanisms of targeted therapy for advanced NSCLC patients with plasma ctDNA EGFR mutation and the evaluation of MRD based on ctDNA detection in perioperative and follow-up monitoring.
ABSTRACT
Aim: We evaluated the incidence, clinicopathological features, prognostic factors and survival of gastric cancer (GC) with bone metastasis in a single large cancer center in China. Patients & methods: Patients with bone metastasis of GC were retrospectively analyzed. Overall survival was estimated using the Kaplan-Meier method. Clinicopathological factors, which were associated with prognostic factors for survival, were evaluated. Results: The incidence of bone metastasis was 11.3% for metastatic GC patients. Median overall survival time was 6.5 months. Multivariate analysis revealed two independent poor prognostic factors: Eastern Cooperative Oncology Group ≥2 (p = 0.023) and lack of palliative chemotherapy (p = 0.018). Conclusion: The incidence of bone metastasis from metastatic GC was underestimated. The prognosis of GC with bone metastasis was poor.
Subject(s)
Biomarkers, Tumor/genetics , Bone Neoplasms/epidemiology , Prognosis , Stomach Neoplasms/epidemiology , Adult , Aged , Bone Neoplasms/genetics , Bone Neoplasms/pathology , Bone Neoplasms/secondary , China/epidemiology , Disease-Free Survival , Female , Gastrectomy , Humans , Kaplan-Meier Estimate , Male , Middle Aged , Neoplasm Staging , Risk Factors , Stomach Neoplasms/genetics , Stomach Neoplasms/pathologyABSTRACT
Enantiopure ligands, namely (R,R)- and (S,S)-2,2'-(1,4-phenylene) bis(4,5-dihydrothiazole-4-carboxylic acid) (H2LRR, and H2LSS) were synthesized, and homochiral metallocyclic rings {Ni6LRR6(H2O)12} (1RR) and {Ni6LSS6(H2O)12} (1SS) were obtained and their structures were determined. The complexes exhibit excellent activity for the photocatalytic degradation of organic dyes.
