ABSTRACT
Five new compounds, iranginins A-E (1-5), together with sixteen known compounds were isolated from the insect pathogenic fungus Ophiocordyceps irangiensis BCC 2728. The structures and the absolute configurations of the new compounds were established by spectroscopic analyses, the application of modified Mosher's method (for 2), ECD calculation (for 5), and X-ray crystallographic analysis (for 4). LL-Z1640-5 and mucorisocoumarin C were active against Mycobacterium tuberculosis (MIC 41.7 and 85.0 µM, respectively), while peyroisocoumarin D exhibited cytotoxic activity (IC50 65.6 µM).
Subject(s)
Antineoplastic Agents , Ants , Hypocreales , Polyketides , Animals , Molecular StructureABSTRACT
Four xanthones (1â4) and a known compound, mansonone D (5), were isolated from the lignicolous freshwater fungus BCC 28210 (family, Chaetosphaeriaceae). The structures of these compounds were elucidated by extensive spectroscopic analysis. Among the isolated metabolites, compound 2 and the known mansonone D (5) displayed antimalarial activity against Plasmodium falciparum K1 with IC50 values of 7.75 and 0.55 µg/mL, respectively. Compound 4 displayed antibacterial activity against Bacillus cereus with an MIC value of 6.25 µg/mL.
Subject(s)
Anti-Bacterial Agents/isolation & purification , Antimalarials/isolation & purification , Ascomycota/chemistry , Xanthones/isolation & purification , Anti-Bacterial Agents/chemistry , Antimalarials/chemistry , Ascomycota/metabolism , Bacillus cereus/drug effects , Fresh Water/microbiology , Inhibitory Concentration 50 , Microbial Sensitivity Tests , Molecular Structure , Naphthoquinones/isolation & purification , Plant Extracts/isolation & purification , Plasmodium falciparum/drug effects , Xanthones/chemistry , Xanthones/pharmacologyABSTRACT
Seven lanostane triterpenoids, ganorbiformins A-G, together with twelve known compounds, were isolated from cultures of the mushroom fungus Ganoderma orbiforme BCC 22324. Ganorbiformin A is an unusual rearranged analog, whereas the other compounds share the same lanostane skeleton with known ganoderic acids. The C-3 epimer of ganoderic acid T also exhibited significant antimycobacterial activity against Mycobacterium tuberculosis H37Ra (MIC 1.3 µM).
