Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 2 de 2
Filter
Add more filters










Database
Type of study
Language
Publication year range
1.
Strahlenther Onkol ; 183(2): 63-8, 2007 Feb.
Article in English | MEDLINE | ID: mdl-17294109

ABSTRACT

PURPOSE: To evaluate the clinical outcome of intensity-modulated radiotherapy (IMRT) in patients with mucosal melanoma (MM) of the nasal cavity and paranasal sinuses. PATIENTS AND METHODS: Between January 1999 and September 2004, eight patients with histologically proven MM of the nasal cavity and paranasal sinuses were treated with IMRT. A median dose of 66 Gy was applied to the macroscopic tumor (gross tumor volume [GTV]; range, 60-68 Gy) as an integrated boost and a median dose of 59 Gy (range, 54-64 Gy) to the clinical target volume (CTV) with IMRT. RESULTS: Treatment-related toxicity was very mild in most patients. Overall survival was 80% at 5 years. Calculated from treatment with IMRT as primary radiotherapy, survival was 100% at 1 year and 75% at 3 years. After IMRT, local progression-free survival was 71.4% at 1 year and 57.1% at 3 years, respectively. Distant progression-free survival after IMRT was 57.1% at 1 year and 28.6% at 3 years. CONCLUSION: Local dose escalation with IMRT yields good treatment results with respect to local and distant tumor control as well as survival, while treatment-related toxicity can be minimized.


Subject(s)
Melanoma/radiotherapy , Nasal Cavity/radiation effects , Nasal Mucosa/radiation effects , Paranasal Sinus Neoplasms/radiotherapy , Radiotherapy, Conformal/methods , Adolescent , Adult , Aged , Dose Fractionation, Radiation , Female , Humans , Male , Middle Aged , Radiation Injuries/etiology , Radiation Injuries/prevention & control , Radiation Protection/methods , Radiotherapy, Conformal/adverse effects , Survival Analysis , Survival Rate , Treatment Outcome
2.
Radiat Oncol ; 1: 23, 2006 Jul 21.
Article in English | MEDLINE | ID: mdl-16859556

ABSTRACT

INTRODUCTION: The aim of the study was to evaluate the clinical outcome of intensity modulated radiotherapy (IMRT) in 46 patients with paranasal sinus tumors with special respect to treatment-related toxicity. PATIENTS AND METHODS: We treated 46 patients with histologically proven tumors of the paranasal sinuses with IMRT. Histological classification included squamous cell carcinoma in 6, adenocarcinoma in 8, adenoidcystic carcinoma in 20 and melanoma in 8 patients, respectively. Six patients had been treated with RT during initial therapy after primary diagnosis, and IMRT was performed for the treatment of tumor progression as re-irradiation. RESULTS: Overall survival rates were 96% at 1 year, 90% at 3 years. Calculated from the initiation of IMRT as primary radiotherapy, survival rates at 1 and 3 years were 95% and 80%. In six patients IMRT was performed as re-irradiation, and survival rate calculated from re-irradiation was 63% at 1 year. Local control rates were 85% at 1, 81% at 2 and 49% at 3 years after primary RT and 50% at 1 year after re-irradiation. Distant metastases-free survival in patients treated with IMRT as primary RT was 83% after 1 and 64% after 3 years. For patients treated as primary irradiation with IMRT, the distant control rate was 83% at 1 year and 0% at 2 years. No severe radiation-induced side-effects could be observed. CONCLUSION: IMRT for tumors of the paranasal sinuses is associated with very good tumor control rates. Treatment-related acute and long-term toxicity can be minimized as compared to historical results with conventional RT.


Subject(s)
Carcinoma/radiotherapy , Paranasal Sinus Neoplasms/radiotherapy , Paranasal Sinuses/radiation effects , Radiotherapy, Intensity-Modulated/methods , Adenocarcinoma/mortality , Adenocarcinoma/radiotherapy , Carcinoma/mortality , Carcinoma, Adenoid Cystic/mortality , Carcinoma, Adenoid Cystic/radiotherapy , Carcinoma, Squamous Cell/mortality , Carcinoma, Squamous Cell/radiotherapy , Female , Humans , Male , Melanoma/radiotherapy , Radiotherapy Dosage , Radiotherapy Planning, Computer-Assisted/methods , Treatment Outcome
SELECTION OF CITATIONS
SEARCH DETAIL
...