ABSTRACT
The cardio-vascular reactions after i.m. application of 0.4 mg/kg of TA (imipramine, amitryptyline and nortryptyline) were compared in normotonics and patients suffering from essential hypertonia. It was found, that systolic blood pressure decreased significantly after the drugs only in hypertonic patients, whereas diastolic blood pressure fall was marked more in the normotonic group. In both groups, no apparent changes in heart action were noticed after the drugs. The TA caused a stronger increase of urine excretion of NE, E, VMA and NMN and MN in hypertonics than in normotonics.
Subject(s)
Antidepressive Agents, Tricyclic/pharmacology , Hemodynamics/drug effects , Hypertension/physiopathology , Amitriptyline/pharmacology , Catecholamines/urine , Humans , Imipramine/pharmacology , Nortriptyline/pharmacologyABSTRACT
Imipramine in doses of 0.35-0.45 mg/kg body weight usually induces a drop in arterial blood pressure; the drop is statistically significant in patients with essential hypertension. In these patients, a significant increase in excretion of catecholamines in urine was observed when compared with a control group. In both groups no changes in heart action were found.
