ABSTRACT
Surgical material is investigated. Morphometric criteria of ultrastructural atypia are considered as a possible prognostic factor of melanoma lymphogenic metastases. This allows detection of skin melanoma with high metastatic potential.
Subject(s)
Melanoma/pathology , Skin Neoplasms/pathology , Humans , Lymphatic Metastasis , Melanoma/surgery , Melanoma/ultrastructure , Middle Aged , Prognosis , Skin Neoplasms/surgery , Skin Neoplasms/ultrastructureABSTRACT
Taking into consideration the age-specific and adaptive changes of the vascular wall, pathomorphologic features of cerebral atherosclerosis were revealed in 236 individuals who died of ischemic heart disease and in 17 patients undergone extra-intracarotid microshunting on the basis of the data obtained from pathomorphologic analysis of the great arteries of the brain. There was a statistically significant prevalence of both the size of the area of atherosclerotic lesions and the incidence of stenosis of the great arteries of the brain in individuals with combined atherosclerosis of cerebral and coronary atherosclerosis. Type-specific peculiarities of atherosclerosis in the areas of reduced blood flow in stenosis of extra- and intracranial arteries were determined.
Subject(s)
Arterial Occlusive Diseases/complications , Brain/blood supply , Coronary Artery Disease/complications , Aged , Aged, 80 and over , Arterial Occlusive Diseases/epidemiology , Coronary Artery Disease/epidemiology , Female , Humans , Male , Middle Aged , PrevalenceABSTRACT
Experiments on rats showed that long-term excess sodium chloride feeding increased the loss of animals as a result of the common carotid artery ligation. The effect is related to maximum decrease in the local cerebral blood flow and sharply pronounced brain swelling. The sodium chloride substitute giposol reduced the extent of cerebral ischemia and produced antiswelling effect. On the background of the hyper-sodium-chloride diet, the protective action of cerebrolysine was less pronounced as manifested by decreasing survival of the test animals. In contrast, the administration of giposol increased the efficacy of cerebrolysine with respect to the carotid artery occlusion.
Subject(s)
Amino Acids/therapeutic use , Brain/drug effects , Cerebrovascular Disorders/drug therapy , Nootropic Agents/therapeutic use , Sodium Chloride, Dietary/administration & dosage , Animals , Brain Edema/drug therapy , Brain Edema/etiology , Brain Edema/mortality , Cerebrovascular Disorders/etiology , Cerebrovascular Disorders/mortality , Disease Models, Animal , Drug Combinations , Drug Evaluation, Preclinical , Drug Synergism , Magnesium Sulfate/therapeutic use , Potassium Chloride/therapeutic use , Rats , Sodium Chloride/therapeutic useABSTRACT
Criteria of myocardial microcirculatory bed functional state under 3 types of blood supply of the heart with non-stenotic and stenotic coronary sclerosis were studied by the stereomorphometric method on 51 autopsies. These were cases of sudden death of acute coronary failure (men from 41 to 70 years old). Different degrees of total and specific volume decrease was found to be in correlation with the decrease in the quantitative parameters of "cardiomyocyte-capillary system". The specific features of interrelationship between parenchyma and capillaries under different types of blood supply show the variants of microcirculatory compensatory potential and explain the reasons for more frequent deaths in the extreme types. There was a direct relationship between the progressive coronary artery atherosclerosis, structure of microarterial bed rearrangement, myocardial circulation and the type of blood supply.
Subject(s)
Coronary Disease/pathology , Coronary Vessels/pathology , Acute Disease , Adult , Aged , Constriction, Pathologic , Humans , Male , Microcirculation/pathology , Middle AgedABSTRACT
Scanning electron microscopy was used to study the microrelief of the intima of coronary arteries in 11 cases of sudden death due to acute coronary insufficiency. In areas of macroscopically intact intima and in zones of minimal atherosclerotic lesions in patients dying of acute coronary insufficiency there were disorganization of intima microrelief with zones of flattening of folds of the first order, the appearance of microplaques with ulceration, dystrophic calcification which reflect early manifestations of coronary artery atherosclerosis. Another group of lesions (diendothelization of the intima with initial signs of parietal thrombus formation) characterizes the functional state of the vessel and serves an indirect criterion of acutely developing spasm of the coronary artery.
