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1.
Tsitol Genet ; 22(1): 24-8, 1988.
Article in Russian | MEDLINE | ID: mdl-3368964

ABSTRACT

The cytogenetic activity of plant growth regulators is investigated in three different test systems. It is shown that three substances (hydrel, dihydrel, camposan) induce no chromosome breaks. MAH-I (maleic acid hydrazide monosodium salt) increases the mutagenic activity in all three investigated test-systems (in somatic and generative cells of rats and in the culture of human lymphocytes). The recrystallized MAH (II) and alar demonstrate an increase in the level of chromosome aberrations in the culture of human lymphocytes and in the bone marrow of rats.


Subject(s)
Chromosome Aberrations , Plant Growth Regulators/pharmacology , Animals , Bone Marrow/drug effects , Cells, Cultured , Dose-Response Relationship, Drug , Female , Genes, Dominant/drug effects , Genes, Lethal/drug effects , Humans , Lymphocytes/drug effects , Male , Mutagenicity Tests , Mutation , Pregnancy , Rats , Spermatozoa/drug effects
2.
Biull Eksp Biol Med ; 93(4): 112-6, 1982 Apr.
Article in Russian | MEDLINE | ID: mdl-7082790

ABSTRACT

The morphological (including electron microscopy, histochemistry, morphometry) and biochemical methods were used in experiments on 478 white rats to determine the content of glycogen, tigroid substance, RNA, DNA and activity of the enzymes (SDH, MDH, LDH, G-6-PDH, phosphorylase) in intact animals after and during exposure to nonionizing microwave radiation (NMR), 30 and 60 days after the rehabilitation period, as well as after physiological exposures (hypoxia and NMR of higher intensity). It was disclosed that repeated exposure to little doses of NMR alters the structural and functional bases of the mechanisms that regulate cell metabolism, produces conformational changes in the chemical substances and thus exerts a damaging action on the delicate cell structures; redistributes the action on the pathways of energy formation at the expense of compensatory protein synthesis and the increase enzymatic systems; increases the resistance to hypoxia and action of NMR of higher intensities.


Subject(s)
Brain/radiation effects , Liver/radiation effects , Microwaves/adverse effects , Animals , Brain/enzymology , Brain/ultrastructure , Dose-Response Relationship, Radiation , Histocytochemistry , Liver/enzymology , Liver/ultrastructure , Oxidative Phosphorylation/radiation effects , Rats , Time Factors
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