[Structural and cytochemical changes in cerebral cortical neurons of the offspring of neurosensitized female rats after prenatal administration of thymalin]. / Strukturnye i tsitokhimicheskie izmeneniia neironov kory mozga potomstva neirosensibilizirovannykh samok krys pri antenata'lnom vvedenii timalina.

Age-related features of structural and cytochemical changes in the brain cortical neurons were investigated in offspring of rats which were neurosensitized and received a course of timalin treatment during gestation. Course treatment with the drug prevented the development of dystrophic changes in cortical neurons, their death and decrease in cell density within the cortical layers. Timalin acted positive in terms of increase in protein content of the cellular nucleus and especially in the cytoplasm. These effects were more pronounced in aged animals. Possible mechanism of timalin action in neurosensitized mothers is discussed.

[Effect of the neurosensitization of female rats on the functional indices of the DNA-, RNA- and protein-synthesizing neuronal apparatus of the cerebral cortex and of the immune system in their progeny]. / Vliianie neirosensibilizatsii samok krys na nekotorye pokazateli sostoianiia DNK-RNK-beloksinteziruiushchego apparata neironov kory golovnogo mozga i immunnoi sistemy u potomstva.

Neurosensitization effects on the state of the ribonucleoprotein particles and chromatin in nuclei of the Vth layer cortical neurons were studied in female rats. Anti-brain antibodies were investigated in their offspring on the 30th and 60th days. On the 60th day the electron-cytochemical changes were found in the nuclei suggesting the deterioration of nucleolar DNA processing and inhibition of nucleolar functional activity. Anti-brain antibodies were also found in the blood. Direct antibodies interference in the function of cellular DNA-RNA-protein-synthetizing system seems plausible.

[Histological and cytochemical changes in the cerebral cortex of the progeny of alcohol-administered animals]. / Gistologicheskie i tsitokhimicheskie izmeneniia kory mozga potomstva alkogolizirovannykh zhivotnykh.

The authors examined the sensomotor cortex of the brain of 30- and 60-day-old progeny of non-inbred female rats alcoholized for 4 months prior to and during pregnancy. The offspring presented structural and cytochemical signs of the malformation of the cerebral cortex and dystrophic changes. Signs characteristic of neuro-ontogenetic impairment include: retardation in the growth of the cortical width, the size of neurons, accumulation in them of protein substances and insufficient variability of classes of neurons in respect of protein concentrations. The above signs of cerebral dysontogenesis are not compensated for by the age of 60 days. Dystrophic-destructive alterations in neurons, augmenting with age, lead to significant depletion of the cortical layers. The authors discuss the role of impairment of the protein-synthetizing system of neurons in the morphological manifestation of the cerebral cortex dysontogenesis and in the development of the dystrophic process.

[Electron microscopic and cytointerferometric study of the cortical neurons from the 2d-generation progeny of preneurosensitized female rats]. / Elektronno-mikroskopicheskoe i tsitointerferometricheskoe issledovanie korkovykh neironov potomstva vtorogo pokoleniia prevaritel'no neirosensibilizirovannykh krys-samok.

A study was made of the sensorimotor cortex of the brain of the second generation offspring of preneurosensitized female rats. Vacuolization of the neurocyte nuclei, elevated lability of nuclear membranes, appearance of numerous dark neurons were discovered at all times of postnatal ontogenesis (from 2 to 90 days). At the same time ultrastructure of a considerable number of neurons was unchanged. The tendency toward normalization of cellular structures was noted by the 3d month. The one-month-old rats demonstrated a decrease in the content of protein substances in the nucleus and cytoplasm of the neurons as compared to normal. By the 3d month this indicator rose but did not reach the control level. It is concluded that neurosensitization of females before pregnancy affects the morphofunctional state of the neurons of the cerebral cortex in both first and second generation offspring, although the changes seen in the latter offspring are less marked, being compensated for with time.

[Dynamics of quantitative shifts in total and perineuronal glia in the cerebral cortex of the progeny of neurosensitized rats]. / Dinamika kolichestvennykh sdvigov obshchei i perineironal'noi glii v kore golovnogo mozga u potomstva neirosensibilizirovannykh krys.

The amount of general and perineuronal glia in the V layer of the sensomotor cortical area was studied during different stages /14-100 days/ of the postnatal period in the progeny born to previously neurosensitized rats. The study demonstrated a decrease in the amount of general glia in the early postnatal period, as well as a drop in amount of perineuronal satellites of large/especially small cells/during all the periods after birth. There was a higher rate in the increase of cortical glial cells in the newborn rats under test. It is assumed that the retardation following stimulation of the process of proliferation migration of glioblasts in the cortex is due to the influence of the neuroautoimmune conflict between the mother and fetus in the antenatal period.

[Histological and electron microscopic study of the cerebral cortex of the progeny of neurosensitized rats]. / Gistologicheskoe i élektronno-mikroskopicheskoe issledovanie kory golovnogo mozga potomstva neirosensibilizirovannykh krys.

The sensomotor brain cortex of 30-day ratlings born by preliminary neurosensitized females, was studied. The studies demonstrated retardation in the development of the brain cortex in the progeny. Electon microscopic examinations detected certain features in the structure of cellular organella, as well as membrane formations in the nuclei of the cortical neurons. These changes are considered as an expression of a lowered level of neuron functioning.

[Effect of preliminary neurosensitization of rats on the postnatal development of the cerebral cortex of the progeny]. / Vliianie predvaritel'noi neirosensibilizatsii krys na postnatal'noe razvitie kory golovnogo mozga potomstva.

The author investigated the cerebral cortex of 30-day ratlings born of rats preliminarily neurosensitized with a homologous cerebral cortex antigen, and of intact, control rats. In comparison with control, there was a reduction of the width of the sensory-motor region of the cortex, chiefly on account of the lower layers, diminution of the size of cell bodies of large neurons in the layer, inadequate development of the cytoplasm, and retarded accumulation of basophilic substance in it.

[Correlation of immunologic and pathomorphologic shifts in mother and fetus following experimental neurosensitization]. / O korreliatsii immunologicheskikh i patomorfologicheskikh sdvigov u materi i ploda pri éksperimental'noi neirosensibilizatsii.

The authors studied mother-rats and their fetuses during the 3 main stages of pregnancy in a sensitation of the rats to homologous brain antigens. Such studies were performed by means of immunological, visual, neurohistological and cytochemical methods. Dystrophical changes were found in the brain of mother-rats and the foetus, while as inflammatory reactions and immunocompetent cells were not seen. The regularities which were detected in the correlative interconnections between the degree and character of immune reactions, the viability of the foetuses, morphological changes and the character of reactions of lysosomal enzymes speak in favour of immune genesis. It appears in the first period and especially in the second period of embryogenesis in nonviability of the foetus and dystrophic brain pathology in the mother and foetus.