ABSTRACT
The effectiveness of three various combinations of an immunomodulator with an antioxidant and a membrane protector in the correction of metabolic and immune disorders has been studied in the experiment under 60-days ethanol intoxication. The development of such biochemical syndromes of the liver damage as cytolysis, intrahepatic, intracellular cholestasis, toxic liver damage by necrotic type, insufficiency of synthetic processes and inflammatory has been revealed. Oxidative stress development and the activation of lipid peroxidation on the systemic (blood plasma) and local level (erythrocytes) have been established. Suppression of adaptive immunity formation and phagocytic capabilities of neutrophils under the increase in their oxygen-dependent activity has been determined, which indicates the presence and possible progression of the inflammatory process at the systemic level. A disorder of erythrocytes metabolic activity, a decrease in stable metabolites of nitric oxide detected in blood plasma been revealed, indicating its uncompensated consumption, causing vasoconstriction and thrombosis, which can additionally arise due to the established increase in the prothrombin index. Combined use of "Longidasa", "Mexicor", "Essentiale forte N" or "Glutoxim", "Mexidol", "Heptral" was more effective in the correction of immune-metabolic disorders in chronic alcohol intoxication than "Hepon", "Hypoxen" and "Phosphogliv".
Subject(s)
Alcoholism/drug therapy , Antioxidants/therapeutic use , Erythrocytes/drug effects , Hypolipidemic Agents/therapeutic use , Immune System/drug effects , Immunologic Factors/therapeutic use , Liver/drug effects , Alcoholism/blood , Alcoholism/immunology , Animals , Antioxidants/administration & dosage , Disease Models, Animal , Drug Therapy, Combination , Erythrocytes/metabolism , Hypolipidemic Agents/administration & dosage , Immunologic Factors/administration & dosage , Lipid Peroxidation/drug effects , Lipid Peroxidation/immunology , Liver/metabolism , Liver Function Tests , Male , Nitric Oxide/blood , Oxidative Stress/drug effects , Oxidative Stress/immunology , Rats, WistarABSTRACT
Amides of all trans-retinoic acid and O-phospho-L-threonine, O-phospho-L-tyrosine, and O-phosphoethanolamine injected intravenously in a dose of 6.8 microg/kg 1.5-3.4-fold increased the count of antibody-producing cells in the spleen of C57Bl/6 mice (primary immune response to sheep erythrocytes). Activity of the complex containing alpha-fetoprotein and L-threonine ligand did not differ from that of free retinoid. This complex holds much promise as a prototype of immunomodulators with a wide range of activity.
