ABSTRACT
The reactions of trans-[PtCl4(RCN)2] (R= Me, Et, CH2Ph, Ph) with the diamines and the triamine NH2{spacer}NH2 (spacer = CH2CH2, CH(Me)CH2, CH2CH2CH2, CH2CH2CH2CH2, CH2CH2NHCH2CH2) in a molar ratio 1 : 2 produce trans-[PtCl4{NH=C(R)NH{spacer}NH2}2] (spacer/R = CH2CH2/Et 1, CH2CHMe/Et 2 (a mixture of regioisomers), CH2CH2CH2/Et 3, CH2CH2CH2CH2/Et 4, CH2CH2/Me 5, CH2CH2/CH2Ph 6, CH2CH2/Ph 7, CH2CH2NHCH2CH2/Et 8) with the monodentately coordinated amidine ligands having the pendant NH2 groups. The complexes have been characterised by C, H, and N elemental analyses, ¹³C CP-MAS NMR and IR spectroscopy, (TOF)-ESI-MS, and [1·H2](Pic)2·EtOH also by X-ray diffraction.
ABSTRACT
Two nitroxide methanofullerenes was synthesized for the first time, and their structures and biological activities studied. It was shown by X-ray single crystal analysis that the methanofullerene with two nitroxide groups forms a 1 : 2 inclusion complex with chloroform and has a nearly tetrahedral (diamond-like) arrangement of fullerene-fullerene interactions in the crystal. For the first time, it has been found that malonate nitroxide methanofullerene in combination with the known anticancer drug cyclophosphamide (CPA) shows high antitumor activity against leukemia P-388.
