[Influence of psychopathological factors and personality traits on the results of the study of quality of life in patients with multiple sclerosis]. / Vliianie psikhopatologicheskikh faktorov i osobennostei lichnosti na rezul'taty issledovaniia kachestva zhizni bol'nykh rasseiannym sklerozom.

AIM: To study the influence of psychopathological factors and personality traits on the results of the study of quality of life (QoL) in patients with multiple sclerosis (MS). MATERIAL AND METHODS: Forty-three patients with relapsing MS were included in the study (74.4% female; mean age 33.1 years). SF-36 was used to evaluate QoL. Effects of psychopathological factors, cognitive regulation of emotions and personality traits on QoL were studied. Statistical analysis was performed using multiple linear model. RESULTS AND DISCUSSION: A wide number of strategies of cognitive regulation of emotions has conflicting effects on the physical component of QoL; subscales of anhedonic depression and anxious arousal (MASQ), which probably represent depressive and anxiety disorders, decrease the physical component of QoL. The key factors of the mental component of QoL include psychopathological factors (mostly obsessive-compulsive symptoms) and personality traits (the more intense they are the lower is QoL). Strategies of cognitive regulation of emotions have low impact on the mental component of QoL.

[Anxiety and depressive psychopathological characteristics of patients with multiple sclerosis at different stages of disease]. / Osobennosti trevozhnykh i depressivnykh rasstroistv u bol'nykh rasseiannym sklerozom na razlichnykh étapakh bolezni.

AIM: To study the development of anxiety and depressive disorders in patients with exacerbated multiple sclerosis (MS). MATERIAL AND METHODS: Forty-three patients with MS were included in the study (women 74.4%, mean age 33.1 years old). SCL-90-R and MASQ questionnaire were used to evaluate psychopathological symptoms. RESULTS AND CONCLUSION: There is the high prevalence of symptoms of anxiety and depression in patients with MS. Other symptoms, including interpersonal sensitivity, hostility and decrease of stress response, are observed as well.

[Atypical multiple sclerosis - Balo's concentric sclerosis: two case-reports and a review]. / Atipichnyi rasseiannyi skleroz - kontsentricheskii skleroz Balo: dva klinicheskikh nabliudeniia i obzor.

This article presents two clinical cases of patients diagnosed with Balo's concentric sclerosis. Distinctive features of the pathogenesis in the aspect of differential diagnosis from other forms of multiple sclerosis and possible treatment are discussed.

[The search for optimal decision in the treatment of multiple sclerosis: to improve adherence not reducing the efficacy]. / Poisk optimal'noi patogeneticheskoi terapii rasseiannogo skleroza: vozmozhnost' povysit' priverzhennost' bol'nykh terapii, ne snizhaia ee éffektivnosti.

Long-term disease modifying therapy (DMD) therapy is the basis of modern MS treatment, effiecacy of which is modulated by the patient's adherence to therapy. One of the possible solutions of low adherence improvement is the use of innovative drugs and the development of more convenient regimens of injectable medications. This article gives a brief review of peg-interferon ß-1a clinical trials.