ABSTRACT
A comparative morphological study of intestinal wall tissues in such chronic colonic diseases, such as Crohn's disease, ulcerative colitis, and catarrhal rectal fistulas, allows the formation of giant cells of foreign bodies and their granulomas and sarcoid-type ones to be nonspecific. Their spread through and outside the colon is due to the migration of foreign bodies along the lymphatic vessels. Foreign inclusions of different shapes and structures in the cytoplasm of giant cells suggest that the colon contains the multiple particles of varying antigenic nature, which induce a unified morphological response medicated by innate and adaptive immunity cells. Consequently, the universally accepted substantiation of the diagnosis of Crohn's disease by the presence of granulomas is unconvincing.
Subject(s)
Crohn Disease , Granuloma , Inflammation/pathology , Colitis, Ulcerative/pathology , Colon/immunology , Colon/pathology , Crohn Disease/diagnosis , Crohn Disease/immunology , Crohn Disease/pathology , Granuloma/complications , Granuloma/immunology , Granuloma/pathology , Humans , Rectal Fistula/pathology , Sarcoidosis/pathologySubject(s)
Antigens, Bacterial/immunology , Binding Sites, Antibody/immunology , Colitis, Ulcerative/immunology , Crohn Disease/immunology , Lymphocytes/immunology , Mycobacterium avium subsp. paratuberculosis/immunology , Epitopes/immunology , Escherichia coli/immunology , Humans , Intestine, Large/immunology , Lymph Nodes/immunology , Mesentery , Staphylococcus aureus/immunologyABSTRACT
The immunohistological study of the large intestines excised from 20 patients with ulcerous colitis and Crohn's disease was made with the use of the indirect immunofluorescence test. A considerable increase in the number of IgG immunocytes has been noted in the lamina propria of the mucous membrane, especially in infiltrations around ulcers. In cases of a highly active inflammatory process accompanied by the pronounced destruction of the epithelium, IgG and C3, C4, C9 were detected in the epithelium of crypts and in blood vessels of the mucous membrane and the submucosa. One-third of the patients showed a decrease in the number of crypts with secretory and serum IgA. The authors suggest that immune complexes take part in maintaining the chronic inflammatory process.