Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 4 de 4
Filter
Add more filters










Database
Language
Publication year range
1.
Sci Adv ; 7(10)2021 03.
Article in English | MEDLINE | ID: mdl-33658191

ABSTRACT

Mnemonic techniques, such as the method of loci, can powerfully boost memory. We compared memory athletes ranked among the world's top 50 in memory sports to mnemonics-naïve controls. In a second study, participants completed a 6-week memory training, working memory training, or no intervention. Behaviorally, memory training enhanced durable, longer-lasting memories. Functional magnetic resonance imaging during encoding and recognition revealed task-based activation decreases in lateral prefrontal, as well as in parahippocampal and retrosplenial cortices in both memory athletes and participants after memory training, partly associated with better performance after 4 months. This was complemented by hippocampal-neocortical coupling during consolidation, which was stronger the more durable memories participants formed. Our findings advance knowledge on how mnemonic training boosts durable memory formation through decreased task-based activation and increased consolidation thereafter. This is in line with conceptual accounts of neural efficiency and highlights a complex interplay of neural processes critical for extraordinary memory.

2.
Neurobiol Learn Mem ; 151: 85-87, 2018 05.
Article in English | MEDLINE | ID: mdl-29689300

ABSTRACT

Variance in spatial abilities are thought to be determined by in utero levels of testosterone and oestrogen, measurable in adults by the length ratio of the 2nd and 4th digit (2D:4D). We confirmed the relationship between 2D:4D and spatial performance using rats in two different tasks (paired-associate task and watermaze) and replicated this in humans. We further clarified anatomical and functional brain correlates of the association between 2D:4D and spatial performance in humans.


Subject(s)
Brain/physiology , Estrogens/physiology , Fingers/physiology , Spatial Learning/physiology , Spatial Memory/physiology , Testosterone/physiology , Animals , Brain Mapping , Fingers/anatomy & histology , Humans , Magnetic Resonance Imaging , Male , Neural Pathways/physiology , Rats
3.
Neuroimage ; 142: 465-473, 2016 Nov 15.
Article in English | MEDLINE | ID: mdl-27402596

ABSTRACT

Ghrelin regulates energy homeostasis in various species and enhances memory in rodent models. In humans, the role of ghrelin in cognitive processes has yet to be characterized. Here we show in a double-blind randomized crossover design that acute administration of ghrelin alters encoding-related brain activity, however does not enhance memory formation in humans. Twenty-one healthy young male participants had to memorize food- and non-food-related words presented on a background of a virtual navigational route while undergoing fMRI recordings. After acute ghrelin administration, we observed decreased post-encoding resting state fMRI connectivity between the caudate nucleus and the insula, amygdala, and orbitofrontal cortex. In addition, brain activity related to subsequent memory performance was modulated by ghrelin. On the next day, however, no differences were found in free word recall or cued location-word association recall between conditions; and ghrelin's effects on brain activity or functional connectivity were unrelated to memory performance. Further, ghrelin had no effect on a cognitive test battery comprising tests for working memory, fluid reasoning, creativity, mental speed, and attention. In conclusion, in contrast to studies with animal models, we did not find any evidence for the potential of ghrelin acting as a short-term cognitive enhancer in humans.


Subject(s)
Brain/drug effects , Brain/physiology , Cognition/physiology , Connectome/methods , Ghrelin/pharmacology , Memory, Long-Term/physiology , Mental Recall/physiology , Adult , Brain/diagnostic imaging , Cognition/drug effects , Cross-Over Studies , Double-Blind Method , Ghrelin/administration & dosage , Humans , Magnetic Resonance Imaging , Male , Memory, Long-Term/drug effects , Mental Recall/drug effects , Young Adult
4.
Neurobiol Learn Mem ; 122: 110-21, 2015 Jul.
Article in English | MEDLINE | ID: mdl-25638277

ABSTRACT

Over the years, rapid eye movement (REM) sleep has been associated with general memory consolidation, specific consolidation of perceptual, procedural, emotional and fear memories, brain maturation and preparation of waking consciousness. More recently, some of these associations (e.g., general and procedural memory consolidation) have been shown to be unlikely, while others (e.g., brain maturation and consciousness) remain inconclusive. In this review, we argue that both behavioral and neurophysiological evidence supports a role of REM sleep for amygdala-related memory processing: the amygdala-hippocampus-medial prefrontal cortex network involved in emotional processing, fear memory and valence consolidation shows strongest activity during REM sleep, in contrast to the hippocampus-medial prefrontal cortex only network which is more active during non-REM sleep. However, more research is needed to fully understand the mechanisms.


Subject(s)
Amygdala/physiology , Memory/physiology , Sleep, REM/physiology , Animals , Emotions/physiology , Extinction, Psychological/physiology , Fear/physiology , Hippocampus/physiology , Humans , Memory Consolidation/physiology , Prefrontal Cortex/physiology
SELECTION OF CITATIONS
SEARCH DETAIL
...